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Keywords: Focal Adhesion
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Journal Articles
J Cell Sci (2024) 137 (9): jcs262116.
Published: 16 May 2024
... cells, which contain an amplification of CASKIN2 , Caskin2 localizes in plasma membrane-associated plaques and around focal adhesions in cortical microtubule stabilization complexes. Taken together, our results identify Caskin2 as a novel talin-binding protein that might not only connect integrin...
Includes: Supplementary data
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In collection:
Adhesion , Cytoskeleton
J Cell Sci (2022) 135 (11): jcs259465.
Published: 6 June 2022
...Alba Zuidema; Wei Wang; Maaike Kreft; Onno B. Bleijerveld; Liesbeth Hoekman; Jonas Aretz; Ralph T. Böttcher; Reinhard Fässler; Arnoud Sonnenberg ABSTRACT The vitronectin receptor integrin αVβ5 can reside in two distinct adhesion structures – focal adhesions (FAs) and flat clathrin lattices (FCLs...
Includes: Supplementary data
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Cell migration
J Cell Sci (2022) 135 (4): jcs259138.
Published: 18 February 2022
... to develop a leading and a trailing end, followed by recruitment of the actin cytoskeleton and formation of cell protrusions and focal adhesions (FAs) at the leading edge. FAs are large complexes consisting of multiple scaffolding and signaling proteins, such as integrins, paxillin and vinculin, which link...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Imaging
J Cell Sci (2022) 135 (3): jcs259430.
Published: 3 February 2022
... contain the non-neuronal proteins LL5β (also known as PHLDB2) and KANK1, which, in migrating cells, organize exocytotic machinery in the vicinity of integrin-based adhesions. Depletion of LL5β or focal adhesion disassembly triggered by myosin II inhibition perturbed the clustering of secretory complexes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (4): jcs254029.
Published: 17 February 2021
...Yi-Chun Liao; Su Hao Lo ABSTRACT Tensins are a family of focal adhesion proteins consisting of four members in mammals (TNS1, TNS2, TNS3 and TNS4). Their multiple domains and activities contribute to the molecular linkage between the extracellular matrix and cytoskeletal networks, as well...
Includes: Supplementary data
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In collection:
Mechanobiology
J Cell Sci (2020) 133 (1): jcs231134.
Published: 3 January 2020
... 2019 © 2020. Published by The Company of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Highlighted Article: Intracellular transglutaminase 2 influences cellular mechanical state, focal adhesion dynamic and FAK activation in response to substrate stiffness, in part...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2020) 133 (1): jcs231134.
Published: 3 January 2020
... 2019 © 2020. Published by The Company of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Highlighted Article: Intracellular transglutaminase 2 influences cellular mechanical state, focal adhesion dynamic and FAK activation in response to substrate stiffness, in part...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2019) 132 (19): jcs232843.
Published: 9 October 2019
... their participation in adhesion turnover and cellular signalling. In this Review, we focus on the interactions between microtubules and integrin-mediated adhesions, in particular, focal adhesions and podosomes. Starting with the association of microtubules with these adhesive structures, we describe the classical...
Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2019) 132 (19): jcs232843.
Published: 9 October 2019
... their participation in adhesion turnover and cellular signalling. In this Review, we focus on the interactions between microtubules and integrin-mediated adhesions, in particular, focal adhesions and podosomes. Starting with the association of microtubules with these adhesive structures, we describe the classical...
Journal Articles
J Cell Sci (2019) 132 (17): jcs225383.
Published: 2 September 2019
... density of inward-rectifier K + channels (K ir 2.1; encoded by KCNJ2 ) and profoundly alter the action potential shape of excitable cells. By using micropatterning to manipulate the localization and size of focal adhesions (FAs) in single HEK293 cells engineered to stably express K ir 2.1 channels...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (17): jcs225383.
Published: 2 September 2019
... density of inward-rectifier K + channels (K ir 2.1; encoded by KCNJ2 ) and profoundly alter the action potential shape of excitable cells. By using micropatterning to manipulate the localization and size of focal adhesions (FAs) in single HEK293 cells engineered to stably express K ir 2.1 channels...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (7): jcs226514.
Published: 3 April 2019
..., as well as for cell migration. Focal adhesions are complex and highly dynamic structures organized around the cytosolic tails of activated β-integrin adhesion receptors ( Zaidel-Bar and Geiger, 2010 ; Wehrle-Haller, 2012 ; Horton et al., 2015 ). Talins are focal adhesion scaffold proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (7): jcs226514.
Published: 3 April 2019
... regulates adhesion complex composition and phosphotyrosine signaling. Talin rod subdomains and their mechanical activation are required for cell polarization and migration. BioID Focal adhesion Mechanobiology Phosphoproteomics Protein engineering Talin Academy of Finland 10.13039...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2019) 132 (2): jcs217349.
Published: 21 January 2019
... gene), both of which localize to focal adhesions, cooperatively function as mechanosensors of ECM stiffness. On a rigid ECM, vinexin α interacts with vinculin and induces a conformational change in vinculin to give an ‘open’ form, which promotes nuclear localization of Yes-associated protein (YAP, also...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2019) 132 (2): jcs217349.
Published: 21 January 2019
... gene), both of which localize to focal adhesions, cooperatively function as mechanosensors of ECM stiffness. On a rigid ECM, vinexin α interacts with vinculin and induces a conformational change in vinculin to give an ‘open’ form, which promotes nuclear localization of Yes-associated protein (YAP, also...
Includes: Supplementary data