...-kinase (PI3K)–Akt pathway. Although some studies have indicated that EGFR signaling may be controlled by signal enrichment within various membrane rafts, such as flotillin nanodomains, others have found a limited effect of disruption of these nanodomains on EGFR signaling, suggesting that specific...

...-MMP is targeted to endolysosomes remains to be elucidated. Flotillin-1 and -2 are upregulated in many invasive cancers. Here, we show that flotillin upregulation triggers a general mechanism, common to carcinoma and sarcoma, which promotes RAB5-dependent MT1-MMP endocytosis and its delivery to RAB7...

... proteins are sorted to the basolateral membrane and then internalized and transported to the apical bile canalicular membrane – a process known as transcytosis. We show that LRP6 is transcytosed to the apical membrane of polarized hepatic HepG2 cells via a flotillin-dependent manner in the absence of LDL...

...Stéphane Bodin; Damien Planchon; Eduardo Rios Morris; Franck Comunale; Cécile Gauthier-Rouvière ABSTRACT Flotillin 1 and 2 are ubiquitous and highly conserved proteins. They were initially discovered in 1997 as being associated with specific caveolin-independent cholesterol- and glycosphingolipid...

...Grant P. Otto; Benjamin J. Nichols Flotillins are membrane proteins that form microdomains in the plasma membrane of all mammalian cell types studied to date. They span the evolutionary spectrum, with proteins related to flotillins present in bacteria, fungi, plants and metazoans, which suggests...

... of endocytosis. These proteins include CtBP (also known as BARS), flotillins (also known as reggies) and GRAF1. We argue that a combination of information about pathway-specific proteins and the ultrastructure of endocytic invaginations provides a means of beginning to classify endocytic pathways. * Author...

...Kirsi Riento; Manfred Frick; Ingmar Schafer; Benjamin J. Nichols Flotillin-1 and flotillin-2 co-assemble into plasma membrane microdomains that are involved in the endocytosis of molecules such as glycosyl phosphatidylinositol (GPI)-linked proteins. Previous studies suggest that budding...

.../flotillin proteins are ubiquitously expressed proteins with a poorly characterized function. They are constitutively associated with membrane rafts by means of acylation and oligomerization. Previous studies have implicated reggies in signaling, regulation of actin cytoskeleton and in membrane transport...

... and animals ( Morrow and Parton, 2005 ; Tavernarakis et al., 1999 ). Fig. 8. Other PHB family members do not localize to the ER. HeLa cells were transfected with pEGFP-N1 containing full-length inserts of prohibitin-1, stomatin-1 isoform a, and flotillin-1 as indicated. Cells were counterstained...