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Keywords: Filamin
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J Cell Sci (2018) 131 (8): jcs213959.
Published: 13 April 2018
...-regulatory proteins. The filamin family of actin-binding proteins exert crucial mechanotransduction and signaling functions in tissue morphogenesis. Filamin-B (FLNB) is a key player in chondrocyte progenitor differentiation for endochondral ossification. Biallelic loss-of-function mutations or gain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (4): 927–938.
Published: 15 February 2013
.... In the present study, we identify the actin cross-linking protein Filamin/Cheerio (Cher) as a mediator of malignancy in genetically defined Drosophila tumors. We show that in invasive tumors, resulting from cooperation of activated Ras with disrupted epithelial cell polarity, Cher is upregulated in a Jun N...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (16): 3858–3869.
Published: 15 August 2012
...Massimiliano Baldassarre; Ziba Razinia; Nina N. Brahme; Roberto Buccione; David A. Calderwood Summary Filamins are an important family of actin-binding proteins that, in addition to bundling actin filaments, link cell surface adhesion proteins, signaling receptors and channels to the actin...
Includes: Multimedia, Supplementary data
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J Cell Sci (2005) 118 (4): 659–664.
Published: 15 February 2005
... is migfilin, a widely expressed protein consisting of an N-terminal filamin-binding domain, a central proline-rich domain and three C-terminal LIM domains. Migfilin is recruited to cell-matrix contacts in response to adhesion and colocalizes with β-catenin at cell-cell junctions in epithelial and endothelial...
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Journal Articles
J Cell Sci (2000) 113 (19): 3499–3508.
Published: 1 October 2000
... with a large hydrophilic loop between TM6 and TM7 that is the site of numerous FAD mutations. Here, we show that the loop region of Drosophila and human presenilins interacts with the C-terminal domain of Drosophila filamin. Furthermore, we show that Drosophila has at least two major filamin forms generated...
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Journal Articles
J Cell Sci (1989) 94 (1): 109–118.
Published: 1 September 1989
...Fredrick M. Pavalko; Carol A. Otey; Keith Burridge ABSTRACT Filamin (actin-binding protein) is a cytoskeletal protein that crosslinks actin filaments in vitro . Filamin is thought to be involved in a variety of cell types in stabilizing actin networks, and in platelets it may play a role in linking...