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Keywords: Fibrosis
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Journal Articles
J Cell Sci (2022) 135 (7): jcs259243.
Published: 12 April 2022
... established from primary hepatocytes of Pkdcc knockout mice produced a secretome, which promoted their own proliferation in 3D spheroids and proliferation of cultured fibroblasts. In vivo , Pkdcc knockout mice developed liver steatosis with signs of inflammation and perivascular fibrosis upon aging, combined...
Includes: Supplementary data
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Polarity
J Cell Sci (2021) 134 (24): jcs259161.
Published: 22 December 2021
... cooperate in kidney collecting duct development, we deleted α3 and α6 in the developing ureteric bud. The collecting system of the double knockout phenocopied the α3 integrin conditional knockout. However, with age, the mice developed severe inflammation and fibrosis around the collecting ducts, resulting...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (18): jcs258643.
Published: 27 September 2021
.... eIF5A Translation Collagen ER stress Fibrosis Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 BFU2016–77728-C3–3-P Generalitat Valenciana http://dx.doi.org/10.13039/501100003359 AICO2020/086 Ministerio de Ciencia, Innovación y...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (18): jcs258429.
Published: 15 September 2021
...Marielle Saclier; Sabrina Ben Larbi; Ha My Ly; Eugénie Moulin; Rémi Mounier; Bénédicte Chazaud; Gaëtan Juban ABSTRACT Duchenne muscular dystrophy is a genetic muscle disease characterized by chronic inflammation and fibrosis mediated by a pro-fibrotic macrophage population expressing pro...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (23): jcs248278.
Published: 11 December 2020
... by tissue labeling with a collagen-hybridizing peptide. Together, these results implicate DRD1 agonism in fibroblast-mediated collagen clearance, suggesting an important role for this mechanism in fibrosis resolution. This article has an associated First Person interview with the first author of the paper...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs227900.
Published: 10 July 2020
... wound granulation tissue and, accordingly, named these cells ‘myofibroblasts’. Now, myofibroblasts are not only recognized for their physiological role in tissue repair but also as cells that are key in promoting the development of fibrosis in all organs. In this Cell Science at a Glance...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs241794.
Published: 21 April 2020
... clear data showing that atypical basement membranes are quite prevalent and that even typical planar basement membranes harbor a lot of diversity that we do not comprehend yet. Collagen IV Drosophila Extracellular matrix Fibrosis Integrin Tissue morphogenesis Multicellular organisms...
Journal Articles
J Cell Sci (2019) 132 (20): jcs233486.
Published: 18 October 2019
...Dakota L. Jones; Andrew J. Haak; Nunzia Caporarello; Kyoung M. Choi; Zhenqing Ye; Huihuang Yan; Xaralabos Varelas; Tamas Ordog; Giovanni Ligresti; Daniel J. Tschumperlin ABSTRACT Tissue fibrosis is a chronic disease driven by persistent fibroblast activation that has recently been linked...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (19): jcs232157.
Published: 9 October 2019
... has not been addressed yet, which indicates that complete and more in-depth research about other signals regulating FAP behavior is needed. In the last few years, we have gained knowledge of the roles of TGF-β and PDGFRα in myopathies and fibrosis ( Ceco and McNally, 2013 ; Smith and Barton, 2018...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs236075.
Published: 26 September 2019
... implantation in a translucent zebrafish model and compare with an acute wound response. We observe inflammation extending from the suture margins, correlating with subsequent avascular and fibrotic encapsulation zones: sutures that induce more inflammation result in increased zones of avascularity and fibrosis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (22): jcs217240.
Published: 20 November 2018
... identifies a core molecular pathway that regulates fibrosis in several organs . Nat. Med.   19 , 1617 - 1624 . 10.1038/nm.3282 Hoang , T. V. , Kumar , P. K. , Sutharzan , S. , Tsonis , P. A. , Liang , C. and Robinson , M. L. ( 2014 ). Comparative transcriptome analysis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (10): jcs209932.
Published: 15 May 2018
...; Robert Vassallo; Daniel J. Tschumperlin ABSTRACT Myofibroblasts play key roles in wound healing and pathological fibrosis. Here, we used an RNAi screen to characterize myofibroblast regulatory genes, using a high-content imaging approach to quantify α-smooth muscle actin stress fibers in cultured human...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (5): jcs201293.
Published: 1 March 2018
... disordered and stiff extracellular matrix (ECM) leading to fibrosis. Fibronectin immobilizes latent TGF-β-binding protein-1 (LTBP-1) and thus stores TGF-β1 in the ECM. Because the ED-A fibronectin splice variant is prominently expressed during fibrosis and supports myofibroblast activation, we investigated...
Journal Articles
J Cell Sci (2018) 131 (4): jcs208629.
Published: 20 February 2018
... , A. , Rose-John , S. , Wong , E. , Sagi , I. , Waikar , S. S. , et al. ( 2016 ). ADAM17 substrate release in proximal tubule drives kidney fibrosis . JCI. Insight.   1 , e87023 . 10.1172/jci.insight.87023 Kleino , I. , Järviluoma , A. , Hepojoki , J. , Huovila...
Includes: Supplementary data
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Adhesion
J Cell Sci (2017) 130 (20): 3481–3495.
Published: 15 October 2017
... healing. Myofibroblast Integrin Fibrosis Scarring Wound healing Tissue scarring and fibrotic disease result from the activities and persistence of myofibroblasts that have failed to undergo apoptosis ( Abe et al., 2012 ; Hinz, 2007 ; Wilson et al., 2007 ). Myofibroblasts derive from...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2016) 129 (10): 1989–2002.
Published: 15 May 2016
... also influences the level and activity of YAP1 in CAFs exposed to a stiff matrix. This work describes a mechanism whereby increased tumor fibrosis can perpetuate activation of CAFs to sustain tumor fibrosis and promote tumor metastasis through regulation of SNAIL1 protein level and activity. Next, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 706–716.
Published: 15 February 2016
... in the extracellular matrix (ECM) of load-bearing tissues such as tendons and cartilage. It provides adaptor functions by bridging different ECM structures. We have previously shown that COMP is also a constitutive component of healthy human skin and is strongly induced in fibrosis. It binds directly and with high...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 653–664.
Published: 15 February 2016
..., their roles in physiological and pathological settings with special emphasis on wound healing, fibrosis and tumor–stroma interactions, and include a discussion of the most recently identified newcomers to this subfamily – integrins α10β1 and α11β1. * Author for correspondence ( donald.gullberg@uib.no...
Journal Articles
J Cell Sci (2016) 129 (4): 774–787.
Published: 15 February 2016
... assembly and MRTF-A nuclear accumulation. Hic-5 MRTF-A Mechanotransduction Myofibroblast Fibrosis Wound healing Western blots were imaged using a Bio-Rad ChemiDoc MP imaging system, and densitometry was performed using Image Lab 4.1 software. Changes in the levels of the proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (6): 1083–1089.
Published: 15 March 2015
...Manish K. Rana; Jyoti Srivastava; Michael Yang; Christopher S. Chen; Diane L. Barber ABSTRACT Increased production and assembly of extracellular matrix proteins during transdifferentiation of epithelial cells to a mesenchymal phenotype contributes to diseases such as renal and pulmonary fibrosis...
Includes: Supplementary data