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Keywords: Fibronectin
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Journal Articles
In collection:
Imaging
J Cell Sci (2021) 134 (4): jcs252957.
Published: 24 February 2021
... Cellular fibronectin (FN; also known as FN1) variants harboring one or two alternatively spliced so-called extra domains (EDB and EDA) play a central bioregulatory role during development, repair processes and fibrosis. Yet, how the extra domains impact fibrillar assembly and function of the molecule...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (9): jcs242404.
Published: 11 May 2020
...) and fibronectin (Fn), which are often presented to cells in culture as homogenous substrates. However, in tissues, cells experience highly complex and changing environments. To better understand integrin ligand selection in such complex environments, we employed binary-choice substrates of Fn and Vn to dissect...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs239186.
Published: 28 April 2020
... the presence of fibronectin on the sperm surface, its role in sperm–sperm interaction as well as participation of β-integrin in the activation of ERK2. Our results show that the signaling pathway downstream of fibronectin, via integrin, FAK, Grb2, MEK1/2, ERK2, GEF-H1 and RhoA regulates the actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (1): jcs232702.
Published: 02 January 2020
...Carolina Diaz; Stefanie Neubauer; Florian Rechenmacher; Horst Kessler; Dimitris Missirlis ABSTRACT The major fibronectin (FN)-binding α 5 β 1 and α v β 3 integrins exhibit cooperativity during cell adhesion, migration and mechanosensing, through mechanisms that are not yet fully resolved...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (8): jcs224493.
Published: 25 April 2019
... and effects on cell proliferation. On fibronectin, GFP-tagged β1A integrin showed dynamic exchange in peripheral focal adhesions, and long, central fibrillar adhesions. In contrast, GFP–β1D integrins exchanged slowly, forming immobile and short central adhesions. While adhesion recruitment of GFP–β1A integrin...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2017) 130 (18): 2971–2983.
Published: 15 September 2017
... lamellipodia in cells plated on a fibronectin substrate. By using a novel optotaxis assay, we show that biased activation can drive directional migration. Interestingly, in the absence of exogenous fibronectin, Rac activation is insufficient to produce stable lamellipodia or directional migration whereas Cdc42...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (11): 2156–2168.
Published: 01 June 2015
... expression inhibited the interaction between integrins and fibronectin, and induced cell morphological changes and proliferation. Inhibition of integrin and fibronectin binding by treatment with the cyclic RGD peptide and fibronectin knockdown induced tubular formation in the presence of EGF alone...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (7): 1316–1326.
Published: 01 April 2015
... progression, the relative abundance of fibronectin receptors, including integrins α5β1 and αvβ3, changes, thus altering the integrin composition of cell–matrix adhesions. Here, we show that enhanced αvβ3 expression can fully compensate for loss of α5β1 and other β1 integrins to support outside-in and inside...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (6): 1083–1089.
Published: 15 March 2015
.... TGF-β and hypoxia, two cues that initiate injury-induced fibrosis, caused human kidney cells to develop a mesenchymal phenotype, including increased fibronectin expression and secretion. However, upon hypoxia, assembled extracellular fibronectin fibrils were mostly absent, whereas treatment with TGF-β...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (17): 3805–3816.
Published: 01 September 2014
...Anthony Ambesi; Paula J. McKeown-Longo ABSTRACT The fibronectin matrix plays a crucial role in the regulation of angiogenesis during development, tissue repair and pathogenesis. Previous work has identified a fibronectin-derived homophilic binding peptide, anastellin, as an effective inhibitor...
Journal Articles
J Cell Sci (2014) 127 (1): 158–171.
Published: 01 January 2014
... cell–cell junctions rich in zona occludens (ZO)-1, β-catenin and heparan sulfate, required syndecan-4 but not fibronectin or protein kinase C α (PKCα) to assemble extracellular matrix (fibrillin microfibrils and perlecan). In contrast, RPE cells that strongly expressed mesenchymal smooth muscle α-actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (22): 5111–5115.
Published: 15 November 2013
... cell niche, in nearby trabeculae and along the glassy membrane. Tenascin-W is also found in the neural stem cell niche of nearby hair follicles. The formation of stress fibers and focal adhesion complexes in CD34-positive whisker-derived stem cells cultured on fibronectin was inhibited by both tenascin...
Journal Articles
J Cell Sci (2012) 125 (21): 5110–5123.
Published: 01 November 2012
... parameters of the ECM that control FA assembly and force transduction in non-migrating cells, we used fibronectin (FN) nanopatterning within a cell adhesion-resistant background to establish the threshold area of ECM ligand required for stable FA assembly and force transduction. Integrin–FN clustering...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (16): 3703–3712.
Published: 15 August 2012
... and during mesenchymal stem cell differentiation. In particular, we focus on the main ECM protein fibronectin, its temporal expression pattern during chondrogenic differentiation, its potential effects on functions of differentiating chondrocytes, and how its interactions with other ECM components might...
Journal Articles
J Cell Sci (2012) 125 (9): 2141–2147.
Published: 01 May 2012
... interactions and the alignment or stabilization of membrane protrusions along fibronectin. Asymmetrical Vangl2 expression in polarized cells would promote or exclude Mmp14 and proteolytic activity from certain cell surfaces and thereby influence cell polarity autonomously and non-autonomously. One prediction...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (24): 4161–4171.
Published: 15 December 2011
... mesenchymal gene, fibronectin ( FN1 ), both in epithelial cells undergoing EMT and in fibroblasts. Together with Snail1, the p65 subunit of NF-κB and PARP1 bound to the FN1 promoter. We detected nuclear interaction of these proteins and demonstrated the requirement of all three for FN1 transcription. Moreover...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (23): 4039–4050.
Published: 01 December 2011
...Feng Shi; Jane Sottile The extracellular matrix (ECM) is dynamically remodeled by cells during development, normal tissue homeostasis and in a variety of disease processes. We previously showed that fibronectin is an important regulator of ECM remodeling. The deposition and/or polymerization...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (8): 1288–1300.
Published: 15 April 2011
... (ECM)-directed crosstalk between platelet-derived growth factor receptor (PDGFR)-β and α5β1-integrin, which controls the migration of mesenchymal stem (stromal) cells (MSCs). Cell adhesion to fibronectin induced α5β1-integrin-dependent phosphorylation of PDGFR-β in the absence of growth factor...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (6): 879–891.
Published: 15 March 2011
... for this process. Using biologically and clinically relevant glomerular podocytes as a model system, we show that integrin activation and dependent processes are tightly regulated by kindlin-2: depletion of kindlin-2 reduced integrin activation, matrix adhesion and fibronectin matrix deposition, whereas...
Journal Articles
J Cell Sci (2011) 124 (4): 515–522.
Published: 15 February 2011
... F. , Longhi R. , Crippa L. , Cattaneo A. , Dondossola E. , Bachi A. , Corti A. ( 2006 ). Spontaneous formation of L-isoaspartate and gain of function in fibronectin . J. Biol. Chem. 281 , 36466 - 36476 . Curnis F. , Sacchi A. , Gasparri...