... vitreous . J. Biol. Chem. 268 , 9381 - 9386 . 10.1016/S0021-9258(18)98361-4 McLaughlin , J. S. , Linsenmayer , T. F. and Birk , D. E. ( 1989 ). Type V collagen synthesis and deposition by chicken embryo corneal fibroblasts in vitro . J. Cell Sci. 94 , 371 - 379...

... remains unclear. Leveraging a unique biological toolset and image analysis pipeline for direct comparison of the variants, we demonstrate that the presence of one or both extra domains impacts FN assembly, function and physical properties of the matrix. When presented to FN-null fibroblasts, extra domain...

... , A. G. , Murphy , M. , Jones , M. K. , Herlyn , M. , Bennett , D. C. , Leonard , J. H. and Sturm , R. A. ( 2003 ). Human melanoblasts in culture: expression of BRN2 and synergistic regulation by fibroblast growth factor-2, stem cell factor, and endothelin-3 . J. Invest...

...Qi Sun; Jiao Miao; Jing Luo; Qi Yuan; Hongdi Cao; Weifang Su; Yang Zhou; Lei Jiang; Li Fang; Chunsun Dai; Ke Zen; Junwei Yang ABSTRACT Renal fibrosis is a final common pathway of chronic kidney disease. Sustained activation of fibroblasts is considered to play a key role in perpetuating renal...

.... Moreover, a stiff extracellular matrix dampens the oscillations of the epithelial molecular clock. Here, we extend this analysis to other tissues and cell types, and identify an inverse relationship between circadian clocks in epithelia and fibroblasts. Epithelial cells from mammary gland, lung and skin...

... predominantly of myogenic cells (CD56 + , desmin + ) and fibroblasts (TE-7 + , collagen VI + , PDGFRα + , vimentin + , fibronectin + ). To evaluate the behaviour of the cell types obtained, we optimised a double immuno-magnetic cell-sorting method for the separation of myogenic cells from fibroblasts...

... in the function of fibroblasts in tissue homeostasis and regeneration. In this study, we characterized the expression of PDGFRβ in fibroblasts derived from human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), and showed that this expression is important for cellular functions...

... culture. In most situations in vivo, however, matrix assembly occurs within existing three-dimensional (3D) extracellular matrix networks. In an attempt to mimic this environment, we analyzed matrix assembly by fibroblasts cultured on a pre-assembled 3D fibronectin matrix and found significant stimulation...

...Florence Debacq-Chainiaux; Céline Borlon; Thierry Pascal; Véronique Royer; François Eliaers; Noëlle Ninane; Géraldine Carrard; Bertrand Friguet; Françoise de Longueville; Sophie Boffe; José Remacle; Olivier Toussaint Premature senescence of human diploid fibroblasts (HDFs) can be induced...

...J. Michael Sorrell; Arnold I. Caplan Dermal fibroblasts are a dynamic and diverse population of cells whose functions in skin in many respects remain unknown. Normal adult human skin contains at least three distinct subpopulations of fibroblasts, which occupy unique niches in the dermis...

..., and receptor tyrosine kinases in fibroblasts) leads to the localized synthesis and accumulation of PtdIns(3,4,5) P 3 /PtdIns(3,4) P 2 at the site of the membrane closest to the chemoattractant source. Use of antibodies specific for PtdIns(3,4,5) P 3 has confirmed the presence of PtdIns(3,4,5) P 3...