... (ECM) contacts (Walker et al., 2008), and autocrine or paracrine effects of growth factors, such as epidermal growth factor (EGF), fibroblast growth factor (FGF) and transforming growth factor β (TGF-β), that induce differentiation of cells as well as changes in ECM properties and composition (e.g...

... diseases. Endothelial cell Endothelial dysfunction Endothelial–mesenchymal transition EndMT Fibroblast growth factor FGF MicroRNA miRNA Transforming growth factor beta TGFβ Netherlands Organisation for Health Research and Development 10.13039/501100001826 916.11.022 40-00506-98...

...Akiko Terauchi; Kendall M. Timmons; Koto Kikuma; Yvonne Pechmann; Matthias Kneussel; Hisashi Umemori ABSTRACT Specific formation of excitatory and inhibitory synapses is crucial for proper functioning of the brain. Fibroblast growth factor 22 (FGF22) and FGF7 are postsynaptic-cell-derived...

...Pavel Krejci; Lisa Salazar; Helen S. Goodridge; Tamara A. Kashiwada; Matthew J. Schibler; Petra Jelinkova; Leslie Michels Thompson; William R. Wilcox Activating mutations in fibroblast growth factor receptor 3 (FGFR3) cause several human skeletal dysplasias as a result of attenuation of cartilage...

...Pavel Krejci; Bernard Masri; Vincent Fontaine; Pertchoui B. Mekikian; MaryAnn Weis; Herve Prats; William R. Wilcox Overexpression of C-natriuretic peptide (CNP) in cartilage partially rescues achondroplasia in the mouse. Here, we studied the interaction of fibroblast growth factor (FGF) and CNP...

... transport assays and confocal microscopy, we now show that fibroblast growth factor 2 (FGF-2), a pro-angiogenic mediator exported from mammalian cells by an unconventional secretory pathway, does not need to be unfolded in order to be released into the extracellular space. These findings suggest...

... stimulation of fibroblast growth factor receptors (FGFRs). Current evidence indicates that Cbl is a key protein that interacts directly with Spry2 following activation of receptor tyrosine kinases (RTKs). It appears to be the ability of Cbl to interact as an E3 ubiquitin ligase on specific target proteins...

... into the extracellular compartment. * Author for correspondence (e-mail: [email protected]) 11 3 2003 © The Company of Biologists Limited 2003 2003 Copper Fibroblast growth factor Interleukin 1 S100A13 Tetrathiomolybdate The prototype members of the IL-1 gene family are well recognized...

...Olav Klingenberg; Antoni Więdłocha; Andrzej Rapak; Denis Khnykin; Lucia Citores; Sjur Olsnes ABSTRACT The ability of COS cells to bind and internalise acidic fibroblast growth factor (aFGF) was studied after transient transfection of the cells with wild-type and mutated fibroblast growth factor...

...Michael J. Cross; Matthew N. Hodgkin; Sally Roberts; Eva Landgren; Michael J. O. Wakelam; Lena Claesson-Welsh ABSTRACT Fibroblast growth factor-mediated signalling was studied in porcine aortic endothelial cells expressing either wild-type fibroblast growth factor receptor-1 or a mutant receptor...

... group of cell surface proteoglycans, the members of the syndecan gene family. angiogenesis extracellular matrix fibroblast growth factor heparan sulfate tumorigenesis Cell surface proteoglycans are membrane-anchored glycoproteins that contain covalently linked glycosaminoglycan sidechains...

...Youqiang Ke; David G. Fernig; Mark C. Wilkinson; John H. R. Winstanley; John A. Smith; Philip S. Rudland; Roger Barraclough ABSTRACT mRNA for basic Fibroblast Growth Factor (bFGF) was expressed in a series of SV40-transformed human mammary cell lines as molecules of 7.1, 3.6, 2.0 and 1.2 kb...

... characteristics of the parental NMuMG cell line. * Author for correspondence 05 03 1993 27 04 1993 © 1993 by Company of Biologists 1993 basic fibroblast growth factor heparin sulfate proteoglycan saporin endocytosis receptors fibroblast growth factor Basic fibroblast...

.... The expression of DIA/LIF in vitro is both developmentally programmed and controlled by the action of other growth factors, the most notable of which are members of the fibroblast growth factor family expressed by the stem cells themselves. This indicates that differentiation and proliferation in early...