... interests The authors declare no competing or financial interests. 26 1 2021 1 12 2021 © 2022. Published by The Company of Biologists Ltd 2022 Summary: Integrin α6β4 is recruited with vimentin to perinuclear focal and fibrillar adhesions indicating how integrin α6β4...

... and effects on cell proliferation. On fibronectin, GFP-tagged β1A integrin showed dynamic exchange in peripheral focal adhesions, and long, central fibrillar adhesions. In contrast, GFP–β1D integrins exchanged slowly, forming immobile and short central adhesions. While adhesion recruitment of GFP–β1A integrin...

... that the modulation of tyrosine phosphorylation of paxillin regulates both the assembly and turnover of adhesion sites. Moreover, phosphorylated paxillin enhanced lamellipodial protrusions, whereas non-phosphorylated paxillin was essential for fibrillar adhesion formation and for fibronectin fibrillogenesis. We...

... FAK in focal adhesions fail to translocate supramolecular complexes of integrin-bound FN and focal adhesion proteins along actin filaments to form mature fibrillar adhesions. Taken together, our data suggest that proper FN allocation and organization are dependent on FAK-mediated remodeling of focal...

... adhesions was localized in large focal contacts in the two mutant cell lines, suggesting involvement of pp60 c-src in the segregation of focal contacts and fibrillar adhesions. Moreover, treatment of wild-type cells with tyrphostin AG1007, which inhibits both pp60 c-src and FAK activity, induced...