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Keywords: Fertilization
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Journal Articles
J Cell Sci (2022) 135 (22): jcs260296.
Published: 23 November 2022
..., with a particular focus on mammalian species. Fertilization Sperm–egg fusion Fusogen Eukaryotes Mammals Ministry of Education, Culture, Sports, Science and Technology http://dx.doi.org/10.13039/501100001700 Japan Society for the Promotion of Science http://dx.doi.org/10.13039...
Includes: Supplementary data
Journal Articles
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Cilia and Flagella
J Cell Sci (2022) 135 (10): jcs259814.
Published: 23 May 2022
... receptors are well studied, fundamental questions remain about the mechanisms and molecules that transduce ciliary signals into responses in the cytoplasm. During fertilization in the bi-ciliated alga Chlamydomonas reinhardtii , ciliary adhesion between plus and minus gametes triggers an immediate ∼10-fold...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (13): jcs257956.
Published: 12 July 2021
..., suggesting that Ca 2+ influx through PM ion channels dictates the periodicity and persistence of Ca 2+ oscillations during mammalian fertilization. * Present address: Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49 – O&N I bis, 09.1140, 3000 Leuven, Belgium. ‡ Author...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (19): jcs221481.
Published: 8 October 2018
... fertile, Cmtm2a and Cmtm2b double mutant mice had defects in male fertility due to impaired sperm function. We found that co-expression of sperm membrane proteins CMTM2A and CMTM2B is required for male fertility and affects the localization of the sperm membrane protein ADAM3 in regulating sperm...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4442–4452.
Published: 1 December 2015
...Miranda L. Bernhardt; Yingpei Zhang; Christian F. Erxleben; Elizabeth Padilla-Banks; Caitlin E. McDonough; Yi-Liang Miao; David L. Armstrong; Carmen J. Williams ABSTRACT Initiation of mouse embryonic development depends upon a series of fertilization-induced rises in intracellular Ca 2+ . Complete...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (12): 2749–2760.
Published: 15 June 2014
...Jose Raul Gonzalez-Garcia; Josephine Bradley; Michail Nomikos; Laboni Paul; Zoltan Machaty; F. Anthony Lai; Karl Swann ABSTRACT Egg activation at fertilization in mammals is initiated by prolonged Ca 2+ oscillations that trigger the completion of meiosis and formation of pronuclei. A fall...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5714–5724.
Published: 15 December 2013
...Takuya Wakai; Nan Zhang; Peter Vangheluwe; Rafael A. Fissore Summary Changes in the intracellular concentration of free calcium ([Ca 2+ ] i ) regulate diverse cellular processes including fertilization. In mammalian eggs, the [Ca 2+ ] i changes induced by the sperm unfold in a pattern of periodical...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (15): 2582–2590.
Published: 1 August 2011
...Michail Nomikos; Khalil Elgmati; Maria Theodoridou; Brian L. Calver; George Nounesis; Karl Swann; F. Anthony Lai Phospholipase C-zeta (PLCζ) is a strong candidate for the mammalian sperm-derived factor that triggers the Ca 2+ oscillations required for egg activation at fertilization. PLCζ lacks...
Journal Articles
J Cell Sci (2010) 123 (9): 1531–1536.
Published: 1 May 2010
...Yoshitaka Fujihara; Masao Murakami; Naokazu Inoue; Yuhkoh Satouh; Kazuhiro Kaseda; Masahito Ikawa; Masaru Okabe Mammalian fertilization is a multistep process that culminates in the fusion of the sperm and egg plasma membrane. It is widely accepted that the equatorial segment of the acrosome...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (21): 3894–3906.
Published: 1 November 2009
... ( bshur@emory.edu ) 24 8 2009 © The Company of Biologists Limited 2009 2009 Sperm-egg binding Fertilization Oviduct-specific glycoprotein Successful fertilization requires numerous, specific interactions between the sperm and egg ( Wassarman et al., 2001 ; Lyng and Shur...
Journal Articles
J Cell Sci (2009) 122 (15): 2741–2749.
Published: 1 August 2009
...Julian Sosnik; Patricia V. Miranda; Nikolay A. Spiridonov; Sook-Young Yoon; Rafael A. Fissore; Gibbes R. Johnson; Pablo E. Visconti One of the most important processes in fertilization is the fusion of egg and sperm; however, the molecular mechanisms involved in this process are not well understood...
Journal Articles
J Cell Sci (2008) 121 (19): 3177–3186.
Published: 1 October 2008
...Miyuki Sato; Barth D. Grant; Akihiro Harada; Ken Sato We previously identified a novel type of caveolin-enriched secretory vesicle in Caenorhabditis elegans oocytes . These vesicles undergo synchronous fusion with the plasma membrane immediately after fertilization, suggesting that they could...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (8): 1341–1349.
Published: 15 April 2007
...Suzannah A. Williams; Lijun Xia; Richard D. Cummings; Rodger P. McEver; Pamela Stanley Fertilization in mammals requires sperm to bind to the zona pellucida (ZP) that surrounds the egg. Galactose (Gal) or N -acetylglucosamine (GlcNAc) residues on the glycans of ZP protein 3 (ZP3) have been...
Journal Articles
J Cell Sci (2006) 119 (17): 3491–3501.
Published: 1 September 2006
... including our previous results show that ERK-LP is inactivated after fertilization, which agrees with results obtained in other species including Xenopus , starfish and mammals. The question is to elucidate the function of a high MAPK activity in sea urchin eggs. We report here that dephosphorylation of ERK...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (15): 3047–3056.
Published: 1 August 2006
... accumulation of phosphorylated MAPKs. Analysis of the interaction partners of β-arrestin2 indicates that odorant receptor signaling in spermatozoa may be important for the regulation of gene expression during the early processes of fertilization. β-Arrestins are regulatory proteins that uncouple agonist...
Journal Articles
J Cell Sci (2006) 119 (3): 416–424.
Published: 1 February 2006
...-philippe.wolf@jvr.ap-hop-paris.fr ) * These authors contributed equally to this work 19 9 2005 © The Company of Biologists Limited 2006 2006 Human Fertilization Integrins Tetraspanins CD9 CD151 Mammalian fertilization depends upon successful binding and fusion between...
Journal Articles
J Cell Sci (2005) 118 (19): 4541–4550.
Published: 1 October 2005
... 500 nm in diameter interconnected with thinner chromatin strands. We propose a unified comprehensive model of chromosomal and nuclear architecture in human sperm that, as we suggest, is important for successful fertilization and early development. * Author for correspondence (e-mail: zalensao...
Journal Articles
J Cell Sci (2005) 118 (17): 3849–3859.
Published: 1 September 2005
...Suzanne Madgwick; Mark Levasseur; Keith T. Jones Mouse eggs arrest at metaphase II following ovulation and are only triggered to complete meiosis when fertilized. Sperm break the cell-cycle arrest by a long-lasting series of Ca 2+ spikes that lead to an activation of the anaphase-promoting complex...
Journal Articles
J Cell Sci (2004) 117 (26): 6269–6274.
Published: 15 December 2004
.... ‡ Author for correspondence (e-mail: dgmyles@ucdavis.edu ) * Present address: Laboratory of Biochemistry and Genetics, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA © The Company of Biologists Limited 2004 2004 Membrane fusion Fertilization Cell-cell fusion Sperm Egg...
Journal Articles
J Cell Sci (2004) 117 (26): 6289–6296.
Published: 15 December 2004
... transduction pathway employed at fertilization, in which a sperm-triggered Ca 2+ signal leads to APC/C-mediated destruction of cell cycle factors that are responsible for egg arrest ( Jones, 2004 ; Tunquist and Maller, 2003 ). * Author for correspondence (e-mail: k.t.jones@newcastle.ac.uk ) 29...