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Keywords: Farnesyltransferase inhibitorClose
Journal: Journal of Cell Science
J Cell Sci (2006) 119 (22): 4644–4649.
Published: 15 November 2006
... of the compromise in genomic integrity. Inactivation of checkpoint kinases Ataxia-telangiectasia-mutated (ATM) and ATR (ATM- and Rad3-related) in these patient cells can partially overcome their early replication arrest. Treatment of patient cells with a protein farnesyltransferase inhibitor (FTI) did not result...