... of the APC/C. We also show that the post-anaphase, KEN-box-dependent degradation of Cenp-F requires it to be farnesylated, a post-translational modification usually linked to membrane association. Because so many of the behaviours of Cenp-F are farnesylation-dependent, we suggest that this modification plays...

...Antonio E. Rusiñol; Michael S. Sinensky Three mammalian nuclear lamin proteins, lamin B 1 , lamin B 2 and the lamin A precursor, prelamin A, undergo canonical farnesylation and processing at CAAX motifs. In the case of prelamin A, there is an additional farnesylation-dependent endoproteolysis...

... * Present address: Research Laboratories of Schering AG, Department of Experimental Dermatology, Müllerstrasse 178, D-13342 Berlin, FRG 28 10 1993 22 12 1993 © 1994 by Company of Biologists 1994 lamin A farnesylation membrane attachment precursor processing proteolysis lamin...

... of high mevalonate uptake. Utilizing this cell line in association with antibodies specific to the transgenic prelamin A, we have been able to demonstrate directly in vivo that prelamin A undergoes farnesylation and car-boxymethylation prior to conversion to lamin A, as is the case for other prenylated...