...Linda Panzer; Leona Trübe; Matthias Klose; Ben Joosten; Johan Slotman; Alessandra Cambi; Stefan Linder ABSTRACT Podosomes are actin-rich adhesion structures that depend on Arp2/3-complex-based actin nucleation. We now report the identification of the formins FHOD1 and INF2 as novel components...

...Nina Schulze; Melanie Graessl; Alexandra Blancke Soares; Matthias Geyer; Leif Dehmelt; Perihan Nalbant ABSTRACT The formin FHOD1 (formin homology 2 domain containing protein 1) can act as a capping and bundling protein in vitro . In cells, active FHOD1 stimulates the formation of ventral stress...

... at the cortex depends on a formin, FHOD1, critically required to organize the cytoskeleton after division. We identify AurB phosphorylation sites in FHOD1 and show that phosphomutant FHOD1 is impaired in post-mitotic assembly of oriented actin cables. We propose that Cdh1 contributes to spatiotemporal...

... at the barbed end. In the present study we show that human FHOD1 lacks actin nucleation and elongation capacity, but acts as an actin bundling factor with capping activity toward the filament barbed end. Constitutively active FHOD1 associates with actin filaments in filopodia and lamellipodia at the leading...

...Sreenivas Koka; Cheryl L. Neudauer; Xiaodong Li; Robert E. Lewis; James B. McCarthy; Jennifer J. Westendorf Formin-homology-domain-containing proteins interact with Rho-family GTPases and regulate actin cytoskeleton organization and gene transcription. FHOD1 is a member of this family, interacts...