...Samantha J. Stehbens; Robert J. Ju; Mark N. Adams; Samuel R. Perry; Nikolas K. Haass; David M. Bryant; Pamela M. Pollock ABSTRACT Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases that control a diverse range of biological processes during development and in adult...

...Giulio Auciello; Debbie L. Cunningham; Tulin Tatar; John K. Heath; Joshua Z. Rappoport Summary Fibroblast growth factor receptors (FGFRs) mediate a wide spectrum of cellular responses that are crucial for development and wound healing. However, aberrant FGFR activity leads to cancer. Activated...

..., whereas FGFR2 and FGFR3 completely lacked this ability. By analyzing mutant FGFRs we found that the tyrosine kinase domain could be deleted from FGFR1 without abolishing translocation, whereas the C-terminal tail of the FGFRs, constituted by approximately 50 amino acids downstream of the kinase domain...

... acid sequence of the intracellular part of the four FGFRs revealed several lysines conserved in FGFR1-3 but absent in FGFR4. Lysines are potential ubiquitylation sites and could thus target a receptor to lysosomes for degradation. Indeed, we found that FGFR4 is less ubiquitylated than FGFR1, which...

...-regulated kinase pathway. These results show that recruitment of SRC to FRS2 leads to activation of signal attenuation pathways. * Author for correspondence (e-mail: j.k.heath@bham.ac.uk ) 1 9 2004 © The Company of Biologists Limited 2004 FGFR FRS2 Sprouty SRC ERK...

... 11 2001 © The Company of Biologists Limited 2002 2002 Brachyury BMP Cartilage Chondrocyte FGFR Signal transduction The murine mesenchymal stem cell line C3H10T1/2 line presents many features of mesenchymal stem cells (MSCs). It can differentiate into mesenchymal lineages...

... in the regulation of neuronal cell proliferation. * Author for correspondence (e-mail: KAL@soton.ac.uk ) 7 09 1998 21 12 1998 © 1999 by Company of Biologists 1999 Antisense Pax-3 Differentiation FGFR Neuronal cell The Pax gene family encodes a family of transcription...