... XBP1 PERK eIF2α ATF4 ATF6 Pancreas Eye In eukaryotic cells, the endoplasmic reticulum (ER) serves as the primary site of folding and maturation of secretory and transmembrane proteins. Nascent polypeptides undergo a complex, multistep chaperone-assisted process of maturation to attain...

...Catherine Cheng; Roberta B. Nowak; Michael B. Amadeo; Sondip K. Biswas; Woo-Kuen Lo; Velia M. Fowler ABSTRACT Tropomyosins (Tpms) stabilize F-actin and regulate interactions with other actin-binding proteins. The eye lens changes shape in order to focus light to transmit a clear image, and thus...

...Marta Sesé; Montserrat Corominas; Hugo Stocker; Tapio I. Heino; Ernst Hafen; Florenci Serras How cellular behaviors such as cell-to-cell communication, epithelial organization and cell shape reorganization are coordinated during development is poorly understood. The developing Drosophila eye...