... colonies in distant organs. CTCs are thought to mimic arrest and extravasation utilized by leukocytes; however, their extravasation also requires processes that, from an endothelial perspective, are specific to cancer cells. Although leukocyte extravasation relies on maintaining endothelial impermeability...

... It is easy to picture TEM as a straightforward cascade of several steps occurring in a sequential manner, starting with the capture of a leukocyte on the endothelium and ending with the leukocyte reaching the source of infection in the interstitium. However, two observations show that leukocyte extravasation...

... in the mouse brain (Movie 1) owing to the limited resolution of IVM. The formation of cellular extensions and the observed drastic remodeling of the endothelial layer close to the tumor cell (Fig. 5) are potentially the earliest steps in extravasation. Recently, invadopodia have been identified as key players...

...Krishma Halai; James Whiteford; Bin Ma; Sussan Nourshargh; Abigail Woodfin ABSTRACT Intercellular adhesion molecule 2 (ICAM-2) is expressed on endothelial cells (ECs) and supports neutrophil extravasation. However, the full details of its role remain unknown, and the present study investigates...

...Konstantin Stoletov; Hisashi Kato; Erin Zardouzian; Jonathan Kelber; Jing Yang; Sanford Shattil; Richard Klemke Little is known about how metastatic cancer cells arrest in small capillaries and traverse the vascular wall during extravasation in vivo. Using real-time intravital imaging of human...