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Keywords: Exocytosis
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Journal Articles
J Cell Sci (2020) 133 (10): jcs241141.
Published: 27 May 2020
...-Fajardo , R. A. , Lu , L. , Takaya , N. , Nienhaus , G. U. and Fischer , R. ( 2017 ). Pulses of Ca 2+ coordinate actin assembly and exocytosis for stepwise cell extension . Proc. Natl. Acad. Sci. USA   114 , 5701 - 5706 . 10.1073/pnas.1700204114 Thomas , L. L. and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (6): jcs236794.
Published: 30 March 2020
..., we show that the F-actin changes occur for all fusing granules, indicating that they are essentially coupled with exocytosis. * Author for correspondence ( p.thorn@sydney.edu.au ) Competing interests The authors declare no competing or financial interests. 22 7 2019 5 2...
Journal Articles
J Cell Sci (2020) 133 (5): jcs240424.
Published: 21 February 2020
...Prasad V. Phatarpekar; Daniel D. Billadeau; Ana-Maria Lennon-Duménil ABSTRACT Natural killer (NK) cells, cytolytic lymphocytes of the innate immune system, play a crucial role in the immune response against infection and cancer. NK cells kill target cells through exocytosis of lytic granules that...
Journal Articles
J Cell Sci (2020) 133 (3): jcs233791.
Published: 12 February 2020
...-mediated regulation of exocytosis . J. Cell Biol.   217 , 945 - 957 . 10.1083/jcb.201705084 Vidali , L. , Augustine , R. C. , Kleinman , K. P. and Bezanilla , M. E. ( 2007 ). Profilin is essential for tip growth in the moss Physcomitrella patens . Plant Cell   19 , 3705...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (2): jcs236737.
Published: 22 January 2020
...://www.biologists.com/user-licence-1-1/ Highlighted Article: The neuronal endocytic adaptor protein AP180 has a dual role in the clearance of release sites and in membrane retrieval in inner hair cells of the murine cochlea. AP180 SNAP91 Ribbon synapse Exocytosis Endocytosis Hearing Electron...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs234781.
Published: 10 October 2019
... , D. A. and Stow , J. L. ( 2005a ). Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha . J. Biol. Chem.   280 , 10478 - 10483 . 10.1074/jbc.M414420200 Murray , R. Z. , Kay , J...
Journal Articles
In collection:
Mitochondria
J Cell Sci (2019) 132 (9): jcs228544.
Published: 30 April 2019
... granule exocytosis. Ca 2+ , in turn, is also rapidly taken up by the mitochondria and exerts important feedback regulation of metabolism. The aim of this study was to determine whether the distribution of mitochondria within beta cells is important for the secretory capacity of these cells. We find that...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (7): jcs227165.
Published: 05 April 2019
...Jeffrey S. Dason; Aaron M. Allen; Oscar E. Vasquez; Marla B. Sokolowski ABSTRACT Sustained neurotransmission requires the tight coupling of synaptic vesicle (SV) exocytosis and endocytosis. The mechanisms underlying this coupling are poorly understood. We tested the hypothesis that a cGMP-dependent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (5): jcs221952.
Published: 15 February 2019
...Camille Lenzi; Jennifer Stevens; Daniel Osborn; Matthew J. Hannah; Ruben Bierings; Tom Carter ABSTRACT Elevations of intracellular free Ca 2+ concentration ([Ca 2+ ] i ) are a potent trigger for Weibel–Palade body (WPB) exocytosis and secretion of von Willebrand factor (VWF) from endothelial cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (23): jcs217638.
Published: 30 November 2018
... secretion of a STAT-activating cytokine. Live imaging suggests that changes in intracellular Ca 2+ are linked to this event. Our data suggest a cell-type specific requirement for particular vesicle trafficking components in regulated exocytosis during development. Given the central role for STAT signaling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (23): jcs213017.
Published: 29 November 2018
...Chien-Chang Huang; Tai-Yu Chiu; Tzu-Ying Lee; Hsin-Jui Hsieh; Chung-Chih Lin; Lung-Sen Kao ABSTRACT α-Synuclein is associated with Parkinson's disease, and is mainly localized in presynaptic terminals and regulates exocytosis, but its physiological roles remain controversial. Here, we studied the...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (16): jcs218610.
Published: 17 August 2018
... described previously ( Singh et al., 2015 ). Then cells were rinsed with ice-cold PBS containing 0.1 mM Ca 2+ and 1 mM Mg 2+ two times at 4°C and incubated for 0, 15, 30 and 60 min at 37°C to allow exocytosis of NHE3. Cells were then labeled with sulfo-NHS-SS-biotin (1.5 mg/ml) and treated with lysis...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (15): 2591–2605.
Published: 01 August 2017
... is von Willebrand factor (VWF) which, following stimulation with secretagogues, is released into the blood vessel lumen as large platelet-catching strings. This exocytosis changes the protein composition of the cell surface and also results in a net increase in the amount of plasma membrane...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (21): 3989–4000.
Published: 01 November 2016
... . Nat. Rev. Immunol.   10 , 440 - 452 . 10.1038/nri2782 Alabi , A. A. and Tsien , R. W. ( 2013 ). Perspectives on kiss-and-run: role in exocytosis, endocytosis, and neurotransmission . Annu. Rev. Physiol.   75 , 393 - 422 . 10.1146/annurev-physiol-020911-153305 Alés , E...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (10): 2085–2095.
Published: 15 May 2016
..., focal targeting of Akt to a region of the cell marked the sites where IRAP–pHluorin vesicles fused, supporting the idea that local Akt-mediated signaling regulates exocytosis. Taken together, these results indicate that PI3K and Akt play distinct roles, and that PI3K stimulates Akt-independent pathways...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (8): 1685–1696.
Published: 15 April 2016
...Nadine Kittelberger; Markus Breunig; René Martin; Hans-Joachim Knölker; Pika Miklavc ABSTRACT Actin and actin-associated proteins have a pivotal effect on regulated exocytosis in secretory cells and influence pre-fusion as well as post-fusion stages of exocytosis. Actin polymerization on secretory...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (3): 592–603.
Published: 01 February 2016
... and MyRIP–MyoVa binding in WPB trafficking and Ca 2+ -driven exocytosis, we used EGFP–MyRIP point mutants with disrupted MyoVa and/or actin binding and high-speed live-cell fluorescence microscopy. We now show that the ability of MyRIP to restrict WPB movement depends upon its actin-binding rather...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (20): 3744–3756.
Published: 15 October 2015
... cell and highly dynamic. The increased mobility of lysosomes in Rapsn −/− cells is associated with a significant increase in lysosomal exocytosis, as evidenced by increased release of lysosomal enzymes and plasma membrane damage when cells were challenged with the bacterial pore-forming toxin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (10): 1946–1960.
Published: 15 May 2015
...Na-Ryum Bin; Chang Hun Jung; Byungjin Kim; Prashanth Chandrasegram; Ekaterina Turlova; Dan Zhu; Herbert Y. Gaisano; Hong-Shuo Sun; Shuzo Sugita ABSTRACT Understanding how Munc18 proteins govern exocytosis is crucial because mutations of this protein cause severe secretion deficits in neuronal and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (24): 5218–5227.
Published: 15 December 2014
...Kathrin Neuland; Neeti Sharma; Manfred Frick ABSTRACT Ca 2+ -dependent regulation of fusion pore dilation and closure is a key mechanism determining the output of cellular secretion. We have recently described ‘fusion-activated’ Ca 2+ entry (FACE) following exocytosis of lamellar bodies in alveolar...
Includes: Supplementary data