...Diego E. Hernández; Natalia A. Salvadores; Guillermo Moya-Alvarado; Romina J. Catalán; Francisca C. Bronfman; Felipe A. Court ABSTRACT Neuronal excitotoxicity induced by glutamate leads to cell death and functional impairment in a variety of central nervous system pathologies. Glutamate-mediated...

...), excitotoxicity, ischemia and oxidative stress ( Patrick et al., 1999 ; Sahlgren et al., 2006 ). In this context, it is important to mention that AD is characterized by accumulation of Aβ peptide as neuritic plaques and of hyperphosphorylated tau as neurofibrillary tangles (NFT), as well as by oxidative stress...

... primarily to the nucleus in various cell types. Recently, reports have described that excitotoxic stress induces DGKζ nucleocytoplasmic translocation in hippocampal neurons. In the study reported here we found that cytoplasmic DGKζ attenuates p53-mediated cytotoxicity against doxorubicin-induced DNA damage...

... (tPA) is the only approved drug for the acute treatment of ischemic stroke. However, tPA also promotes hemorrhagic transformation and excitotoxic events. High mobility group box-1 protein (HMGB-1) is a non-histone transcription factor and a pro-inflammatory cytokine, which has also been shown to bind...

... for neurotrophin-induced differentiation, we investigated whether Kidins220/ARMS and NMDAR functions were related. Here, we identify an association between these proteins and discover that excitotoxicity, a specific form of neuronal death induced by NMDAR overstimulation, dramatically decreases Kidins220/ARMS...

... is notably increased in the hippocampus in a murine model of excitotoxicity. Mice lacking C/EBP β showed a reduced inflammatory response after kainic acid injection, and exhibited a dramatic reduction in pyramidal cell loss in the CA1 and CA3 subfields of the hippocampus. These data reveal an essential...

... of tPA with the NR1 subunit. Immunisation significantly reduced the severity of ischemic and excitotoxic insults in the mouse brain. Cognitive function was altered in some, but not all behavioural tasks affected in tPA-deficient mice. Our data demonstrate that in vivo, tPA controls neurotoxicity...

...Susana R. Parathath; Saj Parathath; Stella E. Tsirka Stroke and many neurodegenerative diseases culminate in neuronal death through a mechanism known as excitotoxicity. Excitotoxicity proceeds through a complex signaling pathway that includes the participation of the serine protease tissue...

...Cristina Vanoni; Silvia Massari; Marco Losa; Paolo Carrega; Carla Perego; Laura Conforti; Grazia Pietrini It has been suggested that glutamate-induced excitotoxicity plays a central role in the development of motor neuron diseases such as amyotrophic lateral sclerosis (ALS). The GLT-1 isoform...

...) is the most prominent hallmark in such excitotoxic injury, little is known about the pathophysiological function of these structural alterations. We used cultured rat hippocampal slices to evaluate the relationship between the formation of varicosities and subsequent neuronal death. Substantial numbers...