... in CV function, in our case emphasizing the role of endosomal vesicle fusion machinery in the D. discoideum CV and facilitating future work to address questions regarding the deep evolution of eukaryotic organelles. References Allen , R. D. and Naitoh , Y. ( 2002 ). Osmoregulation...

... , A. , Colot , V. and Oldroyd , B. P. ( 2021 ). How does epigenetics influence the course of evolution? Phil. Trans. R. Soc. B 376 , 20200111 . 10.1098/rstb.2020.0111 Becker , R. P. and De Bruyn , P. P. H. ( 1976 ). The transmural passage of blood cells into myeloid...

... that autophagy is an evolutionally conserved mechanism to protect eukaryotic cells from starvation and other stresses. Yoshimori and colleagues have demonstrated that Stx17 participates in autophagosome formation at the mitochondria-associated membrane (MAM), where it recruits the Vps34-containing class III...

...-2.1946.0076 Guillot , C. and Lecuit , T. ( 2013 ). Mechanics of epithelial tissue homeostasis and morphogenesis . Science 340 , 1185 - 1189 . 10.1126/science.1235249 Gul , I. S. , Hulpiau , P. , Saeys , Y. and van Roy , F. ( 2017 ). Evolution and diversity...

... differences between prokaryotic and eukaryotic proteins. Fig. 3. Major multiplication and loss events during the evolution of representative ATG proteins. Major multiplication (green) and loss (red) events during the evolution of (A) Atg1, (B) Atg17, (C) Atg11 (FIP200), (D) Atg9, (E) Vps30/Beclin, (F...

... distinct chaperone that forms a tripartite complex with PBAC1 and PBAC2 to promote assembly of the 20S proteasome α-ring in Arabidopsis . Arabidopsis Chaperone Core protease Degradation Evolution Proteasome Proteolysis Proteostasis Regulatory particle Ubiquitin National...

... evolution), wherein negative charge was introduced into the RACK1 loop in protists and dicot plants, and is actively explored across chlorophytes and fungi. Alternatively, these patterns might represent evolutionary pressures driving the loss and/or spatial reorganization of negative charge from ancestral...

... approaches used in comparative biology studies. Chromosome segregation Comparative biology Evolution Mitosis Nuclear envelope Spindle The generality of cell biological mechanisms has become a go-to argument for researchers explaining the relevance of their work to funding bodies...

...Aaron L. Fidler; Sergei P. Boudko; Antonis Rokas; Billy G. Hudson ABSTRACT The cellular microenvironment, characterized by an extracellular matrix (ECM), played an essential role in the transition from unicellularity to multicellularity in animals (metazoans), and in the subsequent evolution...

... important proteins required for this process in trypanosomes. Significantly, these are unique and not present in animals, fungi or plants. Trypanosoma Trafficking Clathrin Cytoskeleton Flagellum Evolution Morphology Eukaryotes originated from a lineage within the Thaumarchaeota...

... a hydrogenosome with novel metabolic properties . Eukaryot. Cell   9 , 1913 - 1924 . 10.1128/EC.00122-10 Berney , C. and Pawlowski , J. ( 2006 ). A molecular time-scale for eukaryote evolution recalibrated with the continuous microfossil record . Proc. R. Soc. B Biol. Sci.   273 , 1867...

... evolutionary comparison of eukaryotic nucleocytoplasmic bridging complexes suggests that they might have evolved from protein complexes involved in attaching centrosomes to the nuclear envelope. KASH protein SUN protein Opisthokonta Archeaplastida Evolution Coiled-coil domain LINC complex...

... adhesion Atomic force microscopy Insect Evolution The main cell–cell adhesion molecules at adherens junctions are members of the classical cadherin family and are conserved across bilaterians ( Harris and Tepass, 2010 ; Hulpiau and van Roy, 2009 ; Miller et al., 2013 ; Oda and Takeichi, 2011...

... to an early stage of evolution. Recent advances have highlighted how this endocytic process can be subverted during pathology – certain cancer cells use macropinocytosis to feed on extracellular protein, and many viruses and bacteria use it to enter host cells. Prion and prion-like proteins can also spread...

...Wenshu Lu; Qiongyu Chen; Songmin Ying; Xiaobing Xia; Zhanru Yu; Yuan Lui; George Tranter; Boquan Jin; Chaojun Song; Leonard W. Seymour; Shisong Jiang ABSTRACT TNF is a primitive protein that has emerged from more than 550 million years of evolution. Our bioinformatics study of TNF from nine...

... of the actin cytoskeleton in time and space . Physiol. Rev.   88 , 1 - 35 . 10.1152/physrev.00001.2007 Hightower , R. C. and Meagher , R. B. ( 1986 ). The molecular evolution of actin . Genetics   114 , 315 - 332 . Hitchcock-DeGregori , S. E. and Heald , R. W. ( 1987...

... work is properly attributed. Endocytosis Evolution Phosphoinositide Trafficking Trypanosome Endocytosis is an essential cellular process in eukaryotes. In animal cells, multiple endocytic pathways exist, but the best understood requires the vesicle coat protein clathrin. Intensive...

... metazoan evolution, which is in stark contrast to the lack of significant Rab family expansions at the onset of most other major eukaryotic groups. Finally, we reconstruct higher-order ancestral clades of Rabs primarily linked with endocytic and exocytic process, suggesting the presence of primordial Rabs...

... § Authors for correspondence ( kirkbeisel@creighton.edu ; hed@creighton.edu ) 26 9 2011 © 2012. 2012 Prestin Protein motif Electromotility Evolution Zebrafish The outer hair cell (OHC) is one of two receptor cells in the organ of Corti, and plays a crucial role in mammalian...

... to the Golgi complex. Here, comparative genomics, cell biology and phylogenetics were used to probe the early evolution of retromer and its function. Retromer subunits Vps26, Vps29 and Vps35 are near universal, and, by inference, the complex was an ancient feature of eukaryotic cells. Surprisingly, we found...