... of cytochrome c from mitochondria into the cytosol. Furthermore, we demonstrated that overexpression of these miRNAs not only caused an increase in apoptosis but also augmented the apoptotic effect of etoposide in breast cancer MCF7 cells. These data not only show the apoptotic nature of miR-195, miR-24-2...

...)-induced apoptosis, we studied the regulation and function of FOXO3 by expressing an ECFP-tagged FOXO3 or a 4OH-tamoxifen (4OHT)-inducible FOXO3–ERtm fusion protein in SH-EP and STA-NB15 neuronal cells. After knockdown of FOXO3 or expression of a dominant-negative FOXO3 mutant we observed that etoposide...

... Hospital, Second Military Medical University, Shanghai 200433, People's Republic of China 5 6 2008 © The Company of Biologists Limited 2008 2008 Cyclase-associated protein Srv2 ASP-56 Reactive oxygen species Cytochrome c Staurosporine Etoposide Cofilin, a member of the ADF...

...Laura García-Bermejo; Concepción Pérez; Nuria E. Vilaboa; Elena de Blas; Patricio Aller ABSTRACT Treatment of U-937 promonocytic cells with the DNA topoisomerase II inhibitor etoposide rapidly caused death by apoptosis, as determined by changes in chromatin structure, production of DNA breaks...

...Concepción Pérez; Nuria E. Vilaboa; Laura García-Bermejo; Elena de Blas; Andrew M. Creighton; Patricio Aller ABSTRACT We have compared the action on U-937 human promonocytic leukemia cells of two DNA topoisomerase II inhibitors, namely the epipodophyllotoxin etoposide and the bisdioxopiperazine...