...Nataly Shulga; John G. Pastorino ABSTRACT Fructose and ethanol are metabolized principally in the liver and are both known to contribute to the development of hepatic steatosis that can progress to hepatic steatohepatitis. The present study indentifies a synergistic interaction between fructose...

...Nataly Shulga; John G. Pastorino Ethanol increases the vulnerability of mitochondria to induction of the mitochondrial permeability transition (MPT). Cyclophilin-D activity enhances the potential for the permeability transition pore (PTP) to open. In the present study, we demonstrate that ethanol...

...Rebeca Miñambres; Rosa M. Guasch; Amparo Perez-Aragó; Consuelo Guerri Anoikis is a programmed cell death induced by loss of anchorage that is involved in tissue homeostasis and disease. Ethanol is an important teratogen that induces marked central nervous system (CNS) dysfunctions. Here we show...

...Reiko Takemura; Yoshiharu Inoue; Shingo Izawa Ethanol stress (10% v/v) causes selective mRNA export in Saccharomyces cerevisiae in a similar manner to heat shock (42°C). Bulk poly(A) + mRNA accumulates in the nucleus, whereas heat shock protein mRNA is exported under such conditions. Here we...

... site of apoB mRNA editing, native p66/ACF, was localized to heterochromatin and fractionated with APOBEC-1 as 27S editosomes. When apoB mRNA editing was stimulated in rat primary hepatocytes with ethanol or insulin, the abundance of p66/ACF in the nucleus markedly increased. It is proposed...