... of Biologists Ltd 2021 Highlighted Article: Laminin-binding integrins play a role in maintaining epithelial cell polarity and decrease pro-inflammatory cytokine secretion by regulating NF-κB-dependent signaling. Inflammation Cytokines Fibrosis Epithelial-to-mesenchymal transition...

...)-AKT pathway signalling. However, their resultant morphological transformed phenotypes are distinct. p110α H1047R induced an epithelial-to-mesenchymal transition (EMT) commensurate with SNAIL (also known as SNAI1) induction and loss of E-cadherin. Upon p110β expression, however, E-cadherin expression...

... and is maintained throughout the neural crest cell epithelial-to-mesenchymal transition (EMT), but its function in these cells is unknown. To this end, we used a combination of in vivo and ex vivo experiments to assess gap junction formation, and Cx43 function, in chick cranial neural crest cells. Our results...

...Varisa Pongrakhananon; Onsurang Wattanathamsan; Masatoshi Takeichi; Paninee Chetprayoon; Pithi Chanvorachote ABSTRACT Epithelial-to-mesenchymal transition (EMT) plays pivotal roles in a variety of biological processes, including cancer invasion. Although EMT involves alterations of cytoskeletal...

...Jonathan Bergeman; Alexia Caillier; François Houle; Laurence M. Gagné; Marc-Étienne Huot ABSTRACT Epithelial-to-mesenchymal transition (EMT) is a process by which cancer cells gain the ability to leave the primary tumor site and invade surrounding tissues. These metastatic cancer cells can further...

...Corinne L. Fairchild; Laura S. Gammill Summary During epithelial-to-mesenchymal transition (EMT), tightly associated, polarized epithelial cells become individual mesenchymal cells capable of migrating. Here, we investigate the role of the transmembrane protein tetraspanin18 (Tspan18) in chick...

...Lauréline Roger; Laurent Jullien; Véronique Gire; Pierre Roux Mutations in the p53 tumour suppressor gene are associated clinically with tumour progression and metastasis. Downregulation of the E-cadherin cell-cell adhesion molecule is a key event for epithelial to mesenchymal transition (EMT...

... © 1999 by Company of Biologists 1999 Vimentin Migration MCF10A EMT Epithelial-to-mesenchymal transition Epithelial cell Vimentin is a type III intermediate filament protein normally expressed in cells of mesenchymal origin ( Steinert and Roop, 1988 ). However, vimentin...