.... These results highlight the importance of the concerted action of extracellular syntaxin4 extruded in response to the lactogenic hormone and BM components in epithelial morphogenesis. From a mechanistic point of view, the spatial epithelial–mesenchymal transition (EMT), which is accompanied by a reduction...

...Tiffany Yu; Miho Matsuda ABSTRACT Erythrocyte protein band 4.1 like 5 (EPB41L5) is an adaptor protein beneath the plasma membrane that functions to control epithelial morphogenesis. Here we report a previously uncharacterized role of EPB41L5 in controlling ciliary function. We found that EPB41L5...

...Ricardo Cruz-Acuña; Adriana Mulero-Russe; Amy Y. Clark; Roy Zent; Andrés J. García ABSTRACT Synthetic hydrogels with controlled physicochemical matrix properties serve as powerful in vitro tools to dissect cell–extracellular matrix (ECM) interactions that regulate epithelial morphogenesis in 3D...

...-licence-1-1/ Summary: A distinctive morphological process of cell alignment in the Drosophila embryonic epithelium reveals that multiple feedback mechanisms in the Rho pathway can fine-tune tissue morphology during development. Rho signaling Epithelial morphogenesis Actomyosin...

... Bioengineering Cylindrical confinement Epithelial morphogenesis In metazoan animals, epithelial tubules are structural features of organs that serve essential functions such as the transport of gases, liquids, metabolites or cells. Also, during embryogenesis, epithelial tubules are often formed...

....2007.11.007 Levayer , R. , Pelissier-Monier , A. and Lecuit , T. ( 2011 ). Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis . Nat. Cell Biol.   13 , 529 - 540 . 10.1038/ncb2224 Liu , Y. , Dong...

... and junctional complexes re-formed. We observed similar epithelial organization during mammary morphogenesis in organotypic culture and in vivo. We conclude that mammary epithelial morphogenesis involves a reversible, spatially limited, reduction in polarity and intercellular junctions and active individualistic...

...@univmed.fr ) 15 9 2011 © 2012. 2012 Apical differentiation Actin network Terminal web Epithelial morphogenesis EB3 microtubule binding protein The complex process of epithelial morphogenesis results in the unique pattern of protein distribution typical of epithelial cells...

... ratio. Together, our results elucidate a mechanism that mediates Crb function and further define the role of PI3K and Rac1 in epithelial morphogenesis, allowing for a better understanding of how distinct membrane domains are regulated in polarized epithelial cells. Epithelial morphogenesis Crumbs...

... endoderm cells. Collectively, these results suggest that integrins are required for both the stable adhesion and maturation of visceral endoderm, the latter being mediated through the activation of ERK1/2 and p38 MAPK. Integrin Epithelial morphogenesis Adhesion GATA4 MAP kinase Integrins...

... epithelial motility, cell-cell adhesion via cadherins controls the remodelling of epithelial sheets. We have used the Drosophila wing epithelium to demonstrate that cell-ECM interactions mediated by integrins also regulate the changes in cell shape that underly epithelial morphogenesis. We show...

... to expand ( Fig. 6C,D , insets). * Author for correspondence (e-mail: roch@cict.fr ) 29 11 2002 ZP proteins Cuticulin envelope Epithelial morphogenesis Cuticule formation Drosophila The epithelium of the Drosophila wing undergoes a conspicuous cytoskeletal...