.... Inhibition of ROCK activity in ARHGAP32 -knockout (KO) cells effectively restored desmosomal organization and the integrity of epithelial cell sheets. Moreover, loss of DSP impaired desmosomal ARHGAP32 location and led to decreased actomyosin contractility. ARHGAP32 with a deletion of the GAB2-ID domain...

... attributed. Summary: Live imaging of the Drosophila intestinal epithelium reveals that stem cells and their terminal progeny exhibit distinct, fate-specific Ca 2+ oscillations that are paced independently of each other. Drosophila Calcium Epithelial cell Live imaging Midgut Stem cell...

... on the cell-type-specific mechanisms regulating ciliogenesis at the apical surface in polarized epithelial cells, which are particularly relevant for many ciliopathies. Furthermore, recent findings have demonstrated the importance of actin cytoskeleton dynamics in positively and negatively regulating multiple...

... and Tsp2A, and is required for the correct localization of these proteins to sSJs. Knockdown of hoka in the adult midgut leads to intestinal barrier dysfunction and stem cell overproliferation. In hoka -knockdown midguts, aPKC is upregulated in the cytoplasm and the apical membrane of epithelial cells...

.... It is also unclear how cellular forces, cell–cell adhesion and velocities are coordinated within streams. To independently tune stiffness and collagen fiber length, we developed new hydrogels and discovered invasion-like streaming of normal epithelial cells on soft substrates coated with long collagen fibers...

...Yasushi Izumi; Kyoko Furuse; Mikio Furuse ABSTRACT Smooth septate junctions (sSJs) contribute to the epithelial barrier, which restricts leakage of solutes through the paracellular route in epithelial cells of the Drosophila midgut. We previously identified three sSJ-associated membrane proteins...

... indispensable for EMT in several types of epithelial cells ( Rana et al., 2018 ). Diaphanous formins can cooperate with VASP in regulation of actin polymerization and serum response factor activity; moreover, these proteins can physically interact with each other ( Grosse et al., 2003 ). In other systems...

.... , Lockett , S. , Desprez , P. Y. and Campisi , J. ( 2001 ). Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging . Proc. Natl. Acad. Sci. USA   98 , 12072 - 12077 . 10.1073/pnas.211053698 Lamia , K. A. , Sachdeva , U. M...

... in experiments using gastric organoids, demonstrating that initial actin polymerization in the lateral membrane is of primary importance for initiation of repair. Actin Epithelial cell Repair Cell migration Gastric organoid Cincinnati Children's Hospital Medical Center 10.13039/100007172...

... junctions ( Guan et al., 2011 ; Marchiando et al., 2011 ). These mechanisms are conserved in several epithelial cell types ( Madara, 1990 ; Rosenblatt et al., 2001 ) and presumably across most vertebrates. Endogenous regulators of constitutive shedding, especially factors that restrain...

...-to-mesenchymal transition (EMT) share certain superficial similarities, but their congruence – or lack thereof – remains unclear. In this Commentary, we discuss aspects of cell jamming, its established role in human epithelial cell layers derived from the airways of non-asthmatic and asthmatic donors, and its...

... role of Cdc42 in ureteric bud and metanephric mesenchyme development is to regulate epithelial cell polarity and the actin cytoskeleton. * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing or financial interests. 10 10 2014...

... Basal body Flagellum Axoneme Cytoskeleton Spermatozoon Epithelial cell Primary cilia are present on the surface of most human cells, and motile cilia are present in tracheal epithelium, ependyma, epididymis, oviduct epithelium, embryonic node and sperm (in the latter case they are called...

... (EDAC), in the neighboring normal cells, and vice versa. These results indicate that EPLIN is a crucial regulator of the interaction between normal and transformed epithelial cells. * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing...

...Yukako Oda; Tetsuhisa Otani; Junichi Ikenouchi; Mikio Furuse ABSTRACT When the surface view of each epithelial cell is compared with a polygon, its sides correspond to cell–cell junctions, whereas its vertices correspond to tricellular contacts, whose roles in epithelial cell morphogenesis have...

... and reproduction in any medium provided that the original work is properly attributed. Epithelial cell Mesenchymal cell Fibrillin-1 Fibronectin Perlecan Integrin Syndecan Cell–cell junction Fibrillin, the main component of microfibrils of the extracellular matrix (ECM), supports elastic fibre...

... . * Author for correspondence ( [email protected] ) 25 6 2012 © 2012. Published by The Company of Biologists Ltd 2012 Drosophila Midgut Epithelial cell Smooth septate junction Epithelia play important roles as barriers that separate distinct compartments within the body...

...Minji Kim; Anirban Datta; Paul Brakeman; Wei Yu; Keith E. Mostov Epithelial cells are polarized, with an apical surface facing a lumen or outer surface and a basolateral surface facing other cells and extracellular matrix (ECM). Hallmarks of epithelial carcinogenesis include loss of polarity...

... and gelatinase-B (MMP-9) and in the collagen invasive activity of A549 cells. Further, we found that epilysin and the recombinant hemopexin domain were targeted to the surface of epithelial cells. This cell surface interaction was sensitive to the proteolytic activity of MT1-MMP, and was lost after EMT. Current...

... of this transporter complex in polarized epithelial cells. CD98 also interacts with β1 integrins resulting in an increase in their affinity for ligand. In this study we explored the role of the transmembrane and cytoplasmic domains of CD98 on integrin-dependent cell adhesion and migration in polarized renal...