... of activating the SRC promoter in response to TGF-β. JUN, a member of the activator protein (AP)-1 family, localises to the enhancer and regulates TGF-β-induced SRC expression. Furthermore, TGF-β-induced SRC upregulation plays a crucial role in epithelial–mesenchymal transition (EMT)-associated cell migration...

... acts coordinately with basement membrane components to trigger mammary cyst formation. Mammary gland Syntaxin4 Epithelial morphogenesis Epimorphin Basement membrane Epithelial–mesenchymal transition Japan Society for the Promotion of Science http://dx.doi.org/10.13039/501100001691...

..., promoting the epithelial–mesenchymal transition (EMT); however, the underlying mechanisms are unknown. We found that silica, matrix stiffening or their combination triggered Ac-α-Tub downregulation in alveolar epithelial cells, followed by DNA damage and replication stress. α-TAT1 elevated Ac-α-Tub to limit...

...Ganlu Deng; Yihong Chen; Cao Guo; Ling Yin; Ying Han; Yiyi Li; Yaojie Fu; Changjing Cai; Hong Shen; Shan Zeng ABSTRACT Epithelial–mesenchymal transition (EMT) is a crucial process for cancer cells to acquire metastatic potential, which primarily causes death in gastric cancer (GC) patients. Bone...

... breast cancer cells with a low level of SIPA1 expression. On the contrary, in MDA-MB-231 breast cancer cells with high SIPA1 expression levels, hypermethylation of the CpG island negatively regulated the transcription of Sipa1 . In addition, the epithelial–mesenchymal transition (EMT) was reversed after...

... described above. Upon confinement, the actin cytoskeleton in non-keratinocyte epitheliocytes was arrested at the circular stage, while in keratinocytes it progressed as far as the radial pattern but still could not break symmetry. Epithelial–mesenchymal transition pushed actin cytoskeleton development from...

...). Adding 0.4–4 ng/ml exogenous (preactivated) TGFβ to subconfluent DCDMLs plated on laminin induces expression of established markers of epithelial–mesenchymal transition (EMT) and/or epithelial–myofibroblast transition (EMyT) after a >3-day treatment (Boswell et al., 2010 , 2017). Compared to cells...

... Summary: Refilins behave as spatiotemporal regulators of the actin-bundling function of filamin and contribute to mechanosensory functions of filamin-B during vertebrate skeletal development. Refilin-A Refilin-B FAM101A FAM101B Filamin Actin TGF-β Epithelial–mesenchymal transition...

... by The Company of Biologists Ltd 2015 EphA2 Epithelial–mesenchymal transition Rho family GTPases Ephrin (Eph)-family receptor tyrosine kinases play pivotal roles in regulating cell migration and proliferation, and contribute to many steps during development and in the maintenance of tissue...

...Junxia Li; Fabo Shan; Gang Xiong; Xuedan Chen; Xingying Guan; Ju-Ming Wang; Wen-Lin Wang; Xueqing Xu; Yun Bai ABSTRACT Epithelial–mesenchymal transition (EMT) is a developmental program that is associated with esophageal squamous cell carcinoma (ESCC) progression and metastasis. Recently, C/EBPβ...

... and could be a useful prognostic marker. However, the role of SCUBE2 in breast-cancer cell migration and invasion and how it is regulated during the epithelial–mesenchymal transition (EMT) remain undefined. In this study, we showed that ectopic SCUBE2 overexpression could enhance the formation of E-cadherin...

... by The Company of Biologists Ltd 2013 Hepatocellular carcinoma Epithelial-mesenchymal transition Wnt–β-catenin signaling HNF4α Hepatocellular carcinoma (HCC) accounts for more than five percent of all cancer cases and is the third leading cause of cancer mortality worldwide (El-Serag and Rudolph...

....00505 Kalluri   R. , Neilson   E. G. (2003). Epithelial-mesenchymal transition and its implications for fibrosis.   J. Clin. Invest.   112 , 1776 – 1784 . Khalil   N. , Corne   S. , Whitman   C. , Yacyshyn   H. (1996). Plasmin regulates the activation of cell...

...Yat-Yuen Lim; Josephine A. Wright; Joanne L. Attema; Philip A. Gregory; Andrew G. Bert; Eric Smith; Daniel Thomas; Angel F. Lopez; Paul A. Drew; Yeesim Khew-Goodall; Gregory J. Goodall Summary The miR-200 family is a key regulator of the epithelial–mesenchymal transition, however, its role...

... are consistent with the epithelial–mesenchymal transition, a feature of invasive cancer cells, and we show that Rab35 expression is suppressed in a subset of cancers characterized by Arf6 hyperactivity. Our data thus identify a key molecular mechanism that efficiently coordinates the inverse intracellular...

...-inflammatory and profibrotic. Cross-talk between TGF-β/Smad and Wnt/β-catenin pathways in epithelial–mesenchymal transition (EMT) suggests a specific role for β-catenin in profibrotic effects of TGF-β1. However, no such mechanistic role has been demonstrated for β-catenin in the anti-inflammatory effects...

...Jelena Stanisavljevic; Montserrat Porta-de-la-Riva; Raquel Batlle; Antonio García de Herreros; Josep Baulida Snail1 is a transcriptional repressor of E-cadherin that triggers epithelial–mesenchymal transition (EMT). Here, we report assisted Snail1 interaction with the promoter of a typical...

... of fibroblast activation protein than did NFs and CAFs. Compared with CAFs and NFs, INFs grown with breast cancer cells were significantly more effective in inducing an epithelial-mesenchymal transition (EMT) in cancer cells, as indicated by induction of vimentin and N-cadherin and downregulation of E-cadherin...

...-cadherin, and upregulation of the mRNAs encoding vimentin, α-smooth muscle actin, α(1)(I) collagen and SNAI1/SIP1, together with formation of actin stress fibers and loss of trans-epithelial resistance were found, confirming an epithelial-mesenchymal transition (EMT). The thyroid-specific and epithelial...

..., radixin, moesin) protein family. Here, we found that human podoplanin directly interacts with ezrin (and moesin) in vitro and in vivo through a cluster of basic amino acids within its cytoplasmic tail, mainly through a juxtamembrane dipeptide RK. Podoplanin induced an epithelial-mesenchymal transition...