... cilium and flagellum – are assembled and positioned, within epithelia, under the control of animal-specific mechanisms for intercellular coordination ( Brunet and Booth, 2023 ). More generally, the evolution of cellular phenotypes might often have involved differential temporal and spatial deployment...

... ). p115RhoGEF activates RhoA to support tight junction maintenance and remodeling . Mol. Biol. Cell 33 , ar136 . 10.1091/mbc.E22-06-0205 Claude , P. and Goodenough , D. A. ( 1973 ). Fracture faces of zonulae occludentes from “tight” and “leaky” epithelia . J. Cell Biol. 58 , 390...

... methods for interrogating the initiation of ADPKD cystogenesis. 3D cell model Epithelia Kidney Tubulogenesis Collecting duct Polycystic kidney disease Baltimore PKD Center National Institute of Diabetes and Digestive and Kidney Diseases 10.13039/100000062 5P30DK090868...

... and Myosin II balance regulates an optimal lateral furrow length for transition of a circular to a polygonal plasma membrane organization in cortical syncytial division cycles in Drosophila embryogenesis. Syncytium Embryo Epithelia Polygon Drosophila DE-cadherin Myosin II Spherical...

... function in the face of cell and tissue dynamics. Actomyosin Barrier function Epithelia Morphogenesis Tight junction Paracellular permeability National Institute of Health 10.13039/100000002 R01 GM112794 National Science Foundation 10.13039/100000001 1615338...

... polarity and polarized morphogenesis of the plasma membrane, with a focus on the epithelial cell type. Cdc42 Epithelia MRCK PAK Par complex Polarity Medical Research Council 10.13039/501100007155 MC UU 12018/3 MC UU 00012/3 Cell polarity – the asymmetric distribution...

... that together promote the fast and efficient closure of tissue discontinuities. The Grainy head family of transcription factors (Grh in flies; GRHL1–GRHL3 in mammals) are essential proteins that have been implicated both in the development and repair of epithelia. However, the genes and the molecular mechanisms...

... feature of epithelial and polarised cells. This Review presents the dynamics of cortical domains in early Drosophila embryos and discusses underlying mechanisms for formation of cortical domains. Drosophila F-actin Cortical compartment Cortical domain Epithelia Deutsche...

..., epithelia at mucosal surfaces must allow selective paracellular flux that discriminates between solutes and water while preventing the passage of bacteria and toxins. In vertebrates, tight junctions seal the paracellular space; flux across the tight junction can occur through two distinct routes that differ...

...George T. Eisenhoffer; Gloria Slattum; Oscar E. Ruiz; Hideo Otsuna; Chase D. Bryan; Justin Lopez; Daniel S. Wagner; Joshua L. Bonkowsky; Chi-Bin Chien; Richard I. Dorsky; Jody Rosenblatt; Andrew Ewald ABSTRACT Epithelia provide a crucial protective barrier for our organs and are also the sites...

...-promoting phosphatase PRL-3 triggers ectopic lumen formation through midbody mispositioning by accelerating cytokinesis, suggesting a new oncogenic mechanism. PRL-3 PTP4A3 Midbody Cell polarity Epithelia Cancer Deutsche Forschungsgemeinschaft 10.13039/501100001659 KO 4013/1-1...

... remains unclear. Here, we examine the hierarchy of events during cytoskeletal polarisation in Drosophila melanogaster epithelia. Core apical-basal polarity determinants polarise the spectrin cytoskeleton to recruit the microtubule-binding proteins Patronin (CAMSAP1, CAMSAP2 and CAMPSAP3 in humans...

... ). Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia . Proc. Natl. Acad. Sci. USA   92 , 10629 - 10633 . 10.1073/pnas.92.23.10629 O'Brien , L. E. , Zegers , M. M. P. and Mostov , K. E. ( 2002 ). Opinion: building epithelial...

.... , Loftus   P. D. , Yoshigi   M. , Otsuna   H. , Chien   C. B. , Morcos   P. A. , Rosenblatt   J. ( 2012 ). Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia.   Nature   484 , 546 – 549 . 10.1038/nature10999 Fadok   V. A. , Bratton   D. L...

... protein kinase.   Proc. Natl. Acad. Sci. USA   104 , 819 – 822 . 10.1073/pnas.0610157104 * Author for correspondence ( [email protected] ) 27 08 2013 © 2013. Published by The Company of Biologists Ltd 2013 Calcium-sensing receptor Epithelia Tight junction...

... differentiation. * Author for correspondence ( [email protected] ) 31 05 2013 © 2013. Published by The Company of Biologists Ltd 2013 EB2 EB1 ACF7 Epithelia Microtubules Cochlea Intestinal crypt Actin filaments Microtubule reorganisation is critical for differentiation...

... suited to coalesce and reorganize actin bundles within the filopodia. * Author for correspondence ( [email protected] ) 13 10 2012 © 2013. Published by The Company of Biologists Ltd 2013 Villin Actin Bundling PtdIns(4,5) P 2 Metastasis Epithelia Filopodia Cell migration...

... and structure of the polarised epithelial actin cytoskeleton. * Author for correspondence ( [email protected] ) 12 1 2010 © 2010. 2010 Par Polarity Epithelia Rho-GTPases Protrusions Actin Animal cells are able to form a number of distinct dynamic actin-filament-based...

... of the complex is restricted to a distinct region of the apical plasma membrane that abuts the zonula adherens in epithelia and photoreceptor cells of invertebrates and vertebrates, including humans. In addition to the core components, a variety of other proteins can be recruited to the complex, depending...

... epithelia ( Peto, 2001 ), and the proliferation and differentiation of epithelial cells are crucially dependent on the EGFR ( Arteaga, 2002 ; Miettinen et al., 1995 ; Sibilia and Wagner, 1995 ; Threadgill et al., 1995 ; Yarden, 2001 ). The EGFR plays fundamental roles in carcinogenesis. EGFR...