... are associated with cell adhesion molecules (CAMs), including Caspr2 (also known as CNTNAP2) and LGI1, which are implicated in autoimmune and genetic neurological diseases with seizures. In particular, mutations in the LGI1 gene cause autosomal dominant lateral temporal lobe epilepsy (ADLTE). Here, by using rat...

... molecular processes. Live-cell fluorescence energy transfer measurements and direct binding studies indicate that remote coiled-coil formation creates conditions for different CaM interaction modes, each conferring different PIP 2 dependency to Kv7.2 channels. Disruption of coiled-coil formation by epilepsy...

...Nicole Terbach; Rishita Shah; Rachel Kelemen; Peter S. Klein; Dmitri Gordienko; Nigel A. Brown; Christopher J. Wilkinson; Robin S. B. Williams Valproic acid (VPA) is the most highly prescribed epilepsy treatment worldwide and is also used to prevent bipolar disorder and migraine. Surprisingly, very...

...-mail: [email protected] ) 9 1 2007 © The Company of Biologists Limited 2007 2007 KCNQ M current Epilepsy Axon initial segment Ankyrin-G Targeting Voltage-gated KCNQ (Kv7) potassium channels are of critical importance in excitable tissue. In the nervous system, KCNQ2/3 channel...