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Keywords: Epigenetics
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Journal Articles
J Cell Sci (2024) 137 (11): jcs261250.
Published: 6 June 2024
...Saikat Bhattacharya; Benjamin P. Tu ABSTRACT An important mechanism of gene expression regulation is the epigenetic modification of histones. The cofactors and substrates for these modifications are often intermediary metabolites, and it is becoming increasingly clear that the metabolic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (7): jcs260801.
Published: 4 April 2023
... of internal lysine residues (lysine acetylation) or acetylation of the α-amino group at the N-terminal amino acid residue (N-terminal acetylation). Although the former modification is considered a classic epigenetic mark, the biological importance of N-terminal acetylation has been mostly overlooked...
Journal Articles
J Cell Sci (2021) 134 (8): jcs254904.
Published: 22 April 2021
... Summary: This Review discusses the ‘nuclear calcium hypothesis’ in the context of human brain function, the role of nuclear Ca 2+ in controlling diverse forms of neuroadaptation and neuroprotection, and its dysregulation in disease. Alzheimer's disease Autophagy CREB signaling Epigenetics...
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Journal Articles
J Cell Sci (2021) 134 (6): jcs244749.
Published: 26 March 2021
... attributed. Summary: Histone variants change the structural properties of nucleosomes by wrapping more or less DNA, altering nucleosome stability or carrying out specialized functions. Chromatin Epigenetics Replacement histones Howard Hughes Medical Institute http://dx.doi.org...
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J Cell Sci (2020) 133 (14): jcs243444.
Published: 21 July 2020
...Yoko Hayashi-Takanaka; Yuto Kina; Fumiaki Nakamura; Leontine E. Becking; Yoichi Nakao; Takahiro Nagase; Naohito Nozaki; Hiroshi Kimura ABSTRACT Post-translational modifications on histones can be stable epigenetic marks or transient signals that can occur in response to internal and external...
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Journal Articles
J Cell Sci (2019) 132 (20): jcs233486.
Published: 18 October 2019
... to epigenetic modifications. Here, we screened a small library of epigenetic small-molecule modulators to identify compounds capable of inhibiting or reversing TGFβ-mediated fibroblast activation. We identified pracinostat, an HDAC inhibitor, as a potent attenuator of lung fibroblast activation and confirmed...
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Journal Articles
J Cell Sci (2016) 129 (5): 1059–1071.
Published: 1 March 2016
... homolog MBDL2 promote Tet2 enzymatic activity, and MBD3L2 enhances the demethylation process mediated by Tet2. MBD3 MBD3L2 Tet2 Enzymatic activity DNA demethylation Epigenetics National Natural Science Foundation of China 10.13039/501100001809 31271355 81272392 National...
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Journal Articles
J Cell Sci (2014) 127 (21): 4645–4657.
Published: 1 November 2014
... factor NF-κB. The epigenetic mechanism underlying LPS-induced pro-inflammatory transcription is not fully understood. Herein, we describe a role for myocardin-related transcription factor A (MRTF-A, also known as MKL1) in this process. MRTF-A overexpression enhanced NF-κB-dependent pro-inflammatory...
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Journal Articles
J Cell Sci (2014) 127 (9): 1857–1867.
Published: 1 May 2014
... of deacetylase, kinase and phosphatase signaling activities. The localized signaling gradients established by targeted O -GlcNAc cycling influence many important cellular processes, including lipid droplet remodeling, mitochondrial functioning, epigenetic control of gene expression and proteostasis...
Journal Articles
J Cell Sci (2013) 126 (10): 2236–2245.
Published: 15 May 2013
... cells Epigenetics Facioscapulohumeral muscular dystrophy (FSHD, OMIM 158900) is the third most common muscular dystrophy, exhibits autosomal dominant inheritance and has no cure ( Cabianca and Gabellini, 2010 ). FSHD typically arises with a reduction of facial and shoulder girdle muscle mass...
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Journal Articles
J Cell Sci (2013) 126 (4): 999–1008.
Published: 15 February 2013
... ecotropic viral integration site-1) increase upon RA treatment of WT, but not RARγ −/− cells. In contrast, Stra8, Dleu7, Leftb, Pitx2, and Cdx1 mRNAs are induced by RA even in the absence of RARγ. Mapping of the epigenetic signature of Meis1 revealed that RA induces a rapid increase in the H3K9/K14ac...
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Journal Articles
J Cell Sci (2012) 125 (16): 3723–3731.
Published: 15 August 2012
... is provided by vernalization, which refers to the acquisition of the ability to flower after prolonged exposure to cold. In Arabidopsis thaliana , vernalization involves downregulation and epigenetic silencing of the gene encoding the floral repressor FLOWERING LOCUS C (FLC). This epigenetic silencing...
Journal Articles
J Cell Sci (2012) 125 (14): 3320–3332.
Published: 15 July 2012
... © 2012. Published by The Company of Biologists Ltd 2012 Amphiregulin Differentiation EGFR Epidermis Epigenetics ERK1/2 Filaggrin Keratinocyte The aryl hydrocarbon receptor nuclear translocator (ARNT or HIF1β) is a basic helix-loop-helix protein that belongs to a Period–ARNT...
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Journal Articles
J Cell Sci (2012) 125 (2): 295–309.
Published: 15 January 2012
... lineage characteristics including the epigenetic mechanisms that regulate NSC self-renewal and lineage commitment in adult neurogenesis. The Qkf–GFP BAC construct used for the generation of transgenic mice was generated by homologous recombination in Escherichia coli using the method...
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In collection:
Metabolism
J Cell Sci (2010) 123 (22): 3837–3848.
Published: 15 November 2010
.... , Luo J. , et al . ( 2007 ). SIRT1 transgenic mice show phenotypes resembling calorie restriction . Aging Cell 6 , 759 - 767 . Borrelli E. , Nestler E. J. , Allis C. D. , Sassone-Corsi P. ( 2008 ). Decoding the epigenetic language of neuronal plasticity . Neuron...
Journal Articles
J Cell Sci (2010) 123 (4): 586–594.
Published: 15 February 2010
.... 2010 Neural stem cells Dicer MicroRNAs Epigenetics Apoptosis Differentiation The precise regulation of proliferation, survival, migration and differentiation of neural stem cells (NSCs) and neural progenitors is crucial for proper formation of the mammalian cerebral cortex during...
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Journal Articles
J Cell Sci (2009) 122 (23): 4296–4302.
Published: 1 December 2009
... of drug addition is a deterministic decision. Fluorescence microscopy Protease Caspase Lineage Epigenetics Apoptosis is a form of cell death that eliminates unwanted or harmful cells ( Ellis et al., 1991 ). It is characterized by the activation of caspases ( Salvesen and Dixit, 1997 ; Yuan...
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