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Keywords: Epigenetics
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Journal Articles
J Cell Sci (2021) 134 (8): jcs254904.
Published: 22 April 2021
... . 10.1084/jem.20161673 Bedford , D. C. , Kasper , L. H. , Fukuyama , T. and Brindle , P. K. ( 2010 ). Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases . Epigenetics 5 , 9 - 15 . 10.4161/epi...
Journal Articles
J Cell Sci (2021) 134 (6): jcs258500.
Published: 29 March 2021
... organization using lac operator/repressor recognition . J. Cell Biol. 135 , 1685 - 1700 . 10.1083/jcb.135.6.1685 Rossetto , D. , Avvakumov , N. and Côté , J. ( 2012 ). Histone phosphorylation: a chromatin modification involved in diverse nuclear events . Epigenetics 7 , 1098...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (6): jcs244749.
Published: 26 March 2021
... attributed. Summary: Histone variants change the structural properties of nucleosomes by wrapping more or less DNA, altering nucleosome stability or carrying out specialized functions. Chromatin Epigenetics Replacement histones Eukaryotic chromatin is organized by nucleosomes, which...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (14): jcs243444.
Published: 21 July 2020
...Yoko Hayashi-Takanaka; Yuto Kina; Fumiaki Nakamura; Leontine E. Becking; Yoichi Nakao; Takahiro Nagase; Naohito Nozaki; Hiroshi Kimura ABSTRACT Post-translational modifications on histones can be stable epigenetic marks or transient signals that can occur in response to internal and external...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (20): jcs233486.
Published: 18 October 2019
... to epigenetic modifications. Here, we screened a small library of epigenetic small-molecule modulators to identify compounds capable of inhibiting or reversing TGFβ-mediated fibroblast activation. We identified pracinostat, an HDAC inhibitor, as a potent attenuator of lung fibroblast activation and confirmed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (5): 1059–1071.
Published: 1 March 2016
... , R. , Lienert , F. and Schübeler , D. ( 2013 ). Methylation-dependent and -independent genomic targeting principles of the MBD protein family . Cell   153 , 480 - 492 . 10.1016/j.cell.2013.03.011 Brown , S. E. and Szyf , M. ( 2007 ). Epigenetic programming...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (21): 4645–4657.
Published: 1 November 2014
... factor NF-κB. The epigenetic mechanism underlying LPS-induced pro-inflammatory transcription is not fully understood. Herein, we describe a role for myocardin-related transcription factor A (MRTF-A, also known as MKL1) in this process. MRTF-A overexpression enhanced NF-κB-dependent pro-inflammatory...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (20): 4368–4380.
Published: 15 October 2014
...) is the main intermediate filament in astrocytes and is regulated by epigenetic mechanisms during development. We demonstrate that histone acetylation also controls GFAP expression in mature astrocytes. Inhibition of histone deacetylases (HDACs) with trichostatin A or sodium butyrate reduced GFAP expression...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (9): 1857–1867.
Published: 1 May 2014
... of deacetylase, kinase and phosphatase signaling activities. The localized signaling gradients established by targeted O -GlcNAc cycling influence many important cellular processes, including lipid droplet remodeling, mitochondrial functioning, epigenetic control of gene expression and proteostasis...
Journal Articles
J Cell Sci (2013) 126 (10): 2236–2245.
Published: 15 May 2013
... for correspondence ( gabellini.davide@hsr.it ) 5 03 2013 © 2013. Published by The Company of Biologists Ltd 2013 Muscular dystrophy Muscle stem cells Epigenetics Facioscapulohumeral muscular dystrophy (FSHD, OMIM 158900) is the third most common muscular dystrophy, exhibits autosomal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (4): 999–1008.
Published: 15 February 2013
... ecotropic viral integration site-1) increase upon RA treatment of WT, but not RARγ −/− cells. In contrast, Stra8, Dleu7, Leftb, Pitx2, and Cdx1 mRNAs are induced by RA even in the absence of RARγ. Mapping of the epigenetic signature of Meis1 revealed that RA induces a rapid increase in the H3K9/K14ac...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (16): 3723–3731.
Published: 15 August 2012
... is provided by vernalization, which refers to the acquisition of the ability to flower after prolonged exposure to cold. In Arabidopsis thaliana , vernalization involves downregulation and epigenetic silencing of the gene encoding the floral repressor FLOWERING LOCUS C (FLC). This epigenetic silencing...
Journal Articles
J Cell Sci (2012) 125 (14): 3320–3332.
Published: 15 July 2012
... of N-OXP 3D epidermal equivalents and concomitant drop in total filaggrin protein level in these models ( Fig. 2C ) further support this suggestion. Amphiregulin Differentiation EGFR Epidermis Epigenetics ERK1/2 Filaggrin Keratinocyte The aryl hydrocarbon receptor nuclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (2): 295–309.
Published: 15 January 2012
... and contributed equally to this work ‡ Authors for correspondence ( avoss@wehi.edu.au ; tthomas@wehi.edu.au ) 22 7 2011 © 2012. 2012 MYST Epigenetics Neurogenesis Neural stem cells HAT Histone acetyltransferase Fluorescence-activated cell sorting Polycomb Adult neural stem...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (2): 411–421.
Published: 15 January 2012
... address: Adolf-Butenandt-Institute, University of Munich, Schillerstrasse 44, 80336 Munich, Germany § Author for correspondence ( bill.earnshaw@ed.ac.uk ) 16 8 2011 © 2012. 2012 Centromere CENP-A Chromatin Epigenetics Human artificial chromosome Kinetochore...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2010) 123 (22): 3837–3848.
Published: 15 November 2010
.... , Luo J. , et al . ( 2007 ). SIRT1 transgenic mice show phenotypes resembling calorie restriction . Aging Cell 6 , 759 - 767 . Borrelli E. , Nestler E. J. , Allis C. D. , Sassone-Corsi P. ( 2008 ). Decoding the epigenetic language of neuronal plasticity . Neuron...
Journal Articles
J Cell Sci (2010) 123 (4): 586–594.
Published: 15 February 2010
... . Chang T. C. , Mendell J. T. ( 2007 ). microRNAs in vertebrate physiology and human disease . Annu. Rev. Genomics Hum. Genet. 8 , 215 - 239 . Cheng L. C. , Tavazoie M. , Doetsch F. ( 2005 ). Stem cells: from epigenetics to microRNAs . Neuron 46 , 363 - 367...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (23): 4296–4302.
Published: 1 December 2009
... of drug addition is a deterministic decision. * Author for correspondence ( simon@rockefeller.edu ) 15 9 2009 © The Company of Biologists Limited 2009 2009 Fluorescence microscopy Protease Caspase Lineage Epigenetics Apoptosis is a form of cell death that eliminates...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (20): 3729–3737.
Published: 15 October 2009
...Li Luo; Katherine L. Gassman; Lydia M. Petell; Christian L. Wilson; Joerg Bewersdorf; Lindsay S. Shopland Chromatin adapts a distinct structure and epigenetic state in embryonic stem cells (ESCs), but how chromatin is three-dimensionally organized within the ESC nucleus is poorly understood...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (5): 667–677.
Published: 1 March 2009
... methylation provides epigenetic transcription memory for retinoid-induced differentiation in myeloid cells. Mol. Cell. Biol. 25 , 5648 -5663. Bates, I. R., Wiseman, P. W. and Hanrahan, J. W. ( 2006 ). Investigating membrane protein dynamics in living cells. Biochem. Cell Biol. 84 , 825 -831...
Includes: Supplementary data