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Keywords: Epidermis
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Journal Articles
J Cell Sci (2020) 133 (23): jcs249102.
Published: 7 December 2020
... development. Epidermis Skin Tumorigenesis Polarity Cell junction Cell adhesion Mitotic spindle orientation Epithelial organization Non-melanoma skin cancer, which includes basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is the most prevalent cancer in the United States...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (21): jcs246793.
Published: 3 November 2020
... epidermis displays a highly ordered parallel stripe pattern as part of its subcellular structure, making it an ideal model to study the formation and reorganization of periodic patterns within cells. Here, we show that the initial formation of periodic striped patterns in the C. elegans epidermis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (5): jcs223586.
Published: 15 February 2019
... functions in the epidermis to instruct skin integrity. Significantly, we show that expression of a mouse RAB6A cDNA can rescue defects in C. elegans epidermis caused by lack of RAB-6.2, suggesting functional conservation across phyla. We also show that the novel function of RAB-6.2 in C. elegans cuticle...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (3): jcs207498.
Published: 1 February 2019
... mechanism within different cells. Circadian clock Epithelial cell Fibroblast Breast Lung Epidermis Circadian gene expression Cells in metazoans live within, and interact with, their local cellular microenvironment. This setting includes the extracellular matrix (ECM) and other cells...
Journal Articles
J Cell Sci (2018) 131 (18): jcs217513.
Published: 20 September 2018
... during terminal keratinocyte differentiation in the epidermis . J. Invest. Dermatol.   133 , 2191 - 2201 . 10.1038/jid.2013.66 Giarmarco , M. M. , Cleghorn , W. M. , Sloat , S. R. , Hurley , J. B. and Brockerhoff , S. E. ( 2017 ). Mitochondria maintain distinct Ca 2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (12): jcs212647.
Published: 28 June 2018
... reorganization and the concentric elongation of surrounding cells. © 2018. Published by The Company of Biologists Ltd 2018 Summary: Rapid wound closure of the vertebrate embryonic epidermis depends on interplay between the cytoskeletal components actin, microtubules and septin. Cytoskeleton...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2018) 131 (10): jcs215780.
Published: 16 May 2018
... differentiate. Activation of epidermal growth factor (EGF) signaling mediated the proliferative response to matrix stiffness and depended on focal adhesion assembly and cytoskeletal tension. Comparison of normal skin with keloid scar tissue further revealed an upregulation of EGF signaling within the epidermis...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2018) 131 (5): jcs208223.
Published: 6 March 2018
... isolates from the back of 6-day-old mice were digested in 0.08% trypsin for 1 h. Epidermis and dermis were then separated, and epidermal cells were strained through 45-µm cell strainers and pelleted at 900 rpm for 3′. For 2D monolayer culture, cells were cultured on fibronectin-coated plastic. For 3D...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (2): jcs202275.
Published: 29 January 2018
... time. Observations on the im leaf epidermis provided another interesting insight ( Fig. 6 F) on plastids. No chlorophyll signal was visible in any epidermal cell type in the white sectors and even within a pavement or guard cell, the leucoplast size varied considerably. Similarly, chloroplasts...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (11): 1917–1928.
Published: 1 June 2017
... that the JAK/STAT pathway suppressed cell fusion during wound healing in the Drosophila larval epidermis, restricting cell fusion to the vicinity of the wound. In the absence of JAK/STAT signaling, a large syncytium containing a 3-fold higher number of nuclei than observed in wild-type tissue formed in wounded...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (14): 3079–3093.
Published: 15 July 2014
... for correspondence ( d.bergamaschi@qmul.ac.uk ) Competing interests The authors declare no competing interests. 21 10 2013 26 03 2014 © 2014. Published by The Company of Biologists Ltd 2014 IASPP Apoptosis Autophagy Mitochondria Epidermis Keratinocytes The epidermis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (16): 3575–3584.
Published: 15 August 2013
... homeostasis. To elucidate the in vivo function of the p18-mediated pathway, we conditionally ablated p18 in the mouse epidermis. Mutant mice were born with severe defects in formation of the stratum corneum and died within 12 h after birth due to dehydration caused by loss of skin barrier function. Mutant...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (15): 3501–3510.
Published: 1 August 2012
... polarity proteins in a range of in vivo processes, including stem cell behavior, cell fate determination, junction formation and maintenance and organ development. Using the epidermis of the skin as a model system, this Commentary aims to discuss the in vivo significance of cell and tissue polarity...
Journal Articles
J Cell Sci (2012) 125 (14): 3320–3332.
Published: 15 July 2012
...E. Douglas Robertson; Lynda Weir; Malgorzata Romanowska; Irene M. Leigh; Andrey A. Panteleyev Summary Previously we showed that spatial and developmental modulation of ARNT (HIF1β) expression in mouse epidermis is essential for maintenance of keratinocyte differentiation, proper formation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (7): 1750–1758.
Published: 1 April 2012
...Lee Wallace; Leiann Roberts-Thompson; Julia Reichelt Keratins K1 and K10 are the most abundant proteins in the upper epidermis where they polymerize to form intermediate filaments (IFs). In addition to their well-established function in providing epidermal stability, K1/K10 (i.e. the dimer between...
Journal Articles
J Cell Sci (2011) 124 (24): 4172–4183.
Published: 15 December 2011
...Hamid Reza Rezvani; Nsrein Ali; Martin Serrano-Sanchez; Pierre Dubus; Christine Varon; Cécile Ged; Catherine Pain; Muriel Cario-André; Julien Seneschal; Alain Taïeb; Hubert de Verneuil; Frédéric Mazurier In mouse and human skin, HIF-1α is constitutively expressed in the epidermis, mainly...
Journal Articles
J Cell Sci (2010) 123 (8): 1363–1372.
Published: 15 April 2010
... reported to form functional mechanosensitive single-membrane channels, but their importance in regulating cellular function is poorly understood. In this study, Panx1 and Panx3 were detected in the epidermis of 13.5 day embryonic mice. Compared with newborn mice, there was less Panx1 expression in both...
Journal Articles
J Cell Sci (2009) 122 (22): 4035–4041.
Published: 15 November 2009
... © The Company of Biologists Limited 2009 2009 Plakins Liprins Epidermis LAR Microtubules Kazrin was originally identified because it binds to the N-terminal domain of the cytolinker periplakin ( Groot et al., 2004 ), which was previously shown to associate with cortical actin...
Journal Articles
J Cell Sci (2009) 122 (15): 2699–2709.
Published: 1 August 2009
...Emilie A. Leclerc; Anne Huchenq; Nicolas R. Mattiuzzo; Daniel Metzger; Pierre Chambon; Norbert B. Ghyselinck; Guy Serre; Nathalie Jonca; Marina Guerrin Corneodesmosin (CDSN) is specific to desmosomes of epithelia undergoing cornification, mainly the epidermis and the inner root sheath of the hair...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (5): 609–617.
Published: 1 March 2008
... percentage of BrdU-positive cells for each FACS-sorted population within the total number of BrdU-positive cells in the entire epidermis per experiment. 2000 cells per population were counted in each experiment and data represent the average of two experiments. * P < 0.05, statistically significant from...
Includes: Supplementary data