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Keywords: Epidermal growth factor receptor
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Journal Articles
J Cell Sci (2021) 134 (18): jcs255927.
Published: 17 September 2021
...Bhuminder Singh; Galina Bogatcheva; Evan Krystofiak; Eliot T. McKinley; Salisha Hill; Kristie Lindsey Rose; James N. Higginbotham; Robert J. Coffey ABSTRACT In polarized MDCK cells, disruption of the tyrosine-based YXXΦ basolateral trafficking motif (Y156A) in the epidermal growth factor receptor...
Includes: Supplementary data
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J Cell Sci (2017) 130 (1): 90–96.
Published: 1 January 2017
... and homeostasis. However, the signals regulating this process are not well understood. We asked whether shedding is controlled by epidermal growth factor receptor (EGFR), an important driver of intestinal growth and differentiation. In 3D ileal enteroid culture and cell culture models (MDCK, IEC-6 and IPEC-J2...
Includes: Supplementary data
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J Cell Sci (2008) 121 (19): 3207–3217.
Published: 1 October 2008
...Rong-Hua Tao; Ichi N. Maruyama The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, also known as ErbB or HER, plays crucial roles in the development of multicellular organisms. Mutations and over-expression of the ErbB receptors have been implicated in a variety...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (15): 3339–3351.
Published: 1 August 2005
... of the internalization, as well as the fact that epidermal growth factor receptors are also internalized, suggest a general induction of clathrin-dependent endocytosis as the mechanism of action. The significance of these findings for the use of cationic CPPs in the import of bioactive peptides is demonstrated here...
Journal Articles
J Cell Sci (2003) 116 (15): 3061–3068.
Published: 1 August 2003
... surrounding a tyrosine residue(Y55 in human Spry2) that is responsible for interaction with other proteins. In cultured mammalian cells, hSpry2 inhibits epidermal growth factor receptor(EGFR) endocytosis and subsequently sustains the activation of MAP kinase but negatively regulates the same pathway following...
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Journal Articles