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Keywords: Epidermal growth factor
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Journal Articles
J Cell Sci (2010) 123 (24): 4310–4320.
Published: 15 December 2010
... ERK regulation in single intact cells, we find that, when protein kinase C or epidermal growth factor receptors are activated, a substantial fraction of the ERK nuclear localization response is uncoupled from TEY phosphorylation. This phosphorylation-unattributable nuclear localization response occurs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (14): 2524–2533.
Published: 15 July 2009
... progenitor cell proliferation. Here, we investigated signaling pathways elicited by ADPβS, UTP and epidermal growth factor (EGF). All three agonists elicit ERK1/2 and CREB phosphorylation but the temporal characteristics differ between the nucleotides and EGF. Differentiation of the progenitors alters...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (8): 1645–1654.
Published: 15 April 2006
... factor receptor (EGFR) through a transactivation process. Healing of wounds in sheets of corneal epithelial cells is absolutely dependent on epidermal growth factor receptor signaling, and the present data suggest that its activation is a result of wound-induced phospholipase D activation. * Author...
Journal Articles
J Cell Sci (2006) 119 (3): 571–581.
Published: 01 February 2006
... show that phosphatidylinositol 4-kinase IIα is also a component of highly dynamic membranes of the endosomal system where it colocalises with protein markers of the late endosome and with endocytosed epidermal growth factor. When phosphatidylinositol 4-kinase IIα activity was inhibited in vivo using...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (26): 6297–6311.
Published: 15 December 2004
... with early endocytic variants Rab4, Rab5, Rab17 and Rab22 but much less overlap with those associated with late endosomes, recycling endosomes and the early secretory pathway. Cells expressing Rab21 T33N had defects in endocytosis of transferrin and epidermal growth factor and failed to effectively deliver...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (10): 2029–2036.
Published: 15 April 2004
... with a PPARγ antagonist, GW9662, which attenuated the TZ-induced response in a dose-specific manner. The PPARγ-mediated effect on UP gene expression was maximal when there was concurrent inhibition of autocrine-activated epidermal growth factor receptor (EGFR) signalling through either the phosphatidylinositol...
Journal Articles
J Cell Sci (2004) 117 (7): 1211–1220.
Published: 01 March 2004
... the lysosomal and ubiquitin-proteasome pathway. It was previously shown that the proteasome is involved in regulating the number of functional gap junctions at the plasma membrane. However, little is known about how proteasome-dependent turnover of Cx43 is controlled. Epidermal growth factor (EGF) induces...
Journal Articles
J Cell Sci (2003) 116 (23): 4799–4810.
Published: 01 December 2003
... membrane. Although the plasma membrane-localized activity of Rab5 was not detected by light microscopy, overexpression of a GDP-bound mutant of CFP-Rab5(S34N) inhibited internalization of the epidermal growth factor receptor by retaining receptors in clathrin-coated pits. To test whether the Rab5(S34N...
Journal Articles
J Cell Sci (2001) 114 (20): 3717–3725.
Published: 15 October 2001
.... Because growth factors are generally believed to regulate glial functions, we addressed their possible contribution to GLAST regulation in cultured rat astrocytes. Of the six growth factors tested (basic fibroblast growth factor (bFGF), insulin-like growth factor-1 (IGF-1), epidermal growth factor (EGF...