.... Our findings provide evidence for a critical role of IL-6 signaling in regulating shock-induced epigenetic changes and sustained endothelial activation, offering a new therapeutic target to limit vascular dysfunction. Fig. 1. LPS-induced DNA methylation changes in the mouse kidney endothelium...

...-scale membrane dynamics Endothelium Transendothelial cell macroaperture Bacterial toxin Actin cytoskeleton Fondation pour la Recherche Médicale http://dx.doi.org/10.13039/501100002915 DEQ20180339156 FDT201904008135 Agence Nationale de la Recherche http://dx.doi.org/10.13039...

.... , Frontini , A. , Zingaretti , M. C. , Morroni , M. , Giordano , A. , Smorlesi , A. , Perugini , J. , De Matteis , R. , Sbarbati , A. et al. ( 2012 ). The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells . Cell Metab. 15 , 222...

... factor in many metabolic diseases ( Ducommun et al., 2015 ). However, studies on its potential role in endothelial barrier function are limited. A lung endothelium wound healing study revealed that AMPK is involved in TJ reinforcement, thereby facilitating barrier repair ( Creighton et al., 2011...

..., including rolling, adhesion, crawling, diapedesis and sub-endothelial crawling. Nowadays, the role of the endothelium in transmigration is increasingly appreciated. It has been established that leukocyte exit sites on the endothelium and in the pericyte layer are in fact not random but instead may...

... ), which might relate to differences in YAP/TAZ mechanosensing and indicates that the function of DLC1 is highly dependent on the cellular microenvironment. Within blood vessels, mechanotransduction through integrins predominantly occurs in arterial endothelium ( Van Geemen et al., 2014 ; Di Russo et al...

... 2019 Summary: Endothelial cell–cell contacts protect tissues from edema and uncontrolled invasion of inflammatory cells. Here, we discuss the emerging role of ubiquitylation of specific proteins controlling endothelial integrity and inflammation. Endothelium Inflammation Ubiquitin...

...Valeria Prystopiuk; Benedikt Fels; Caroline Sophie Simon; Ivan Liashkovich; Dzmitry Pasrednik; Cornelius Kronlage; Roland Wedlich-Söldner; Hans Oberleithner; Johannes Fels ABSTRACT The vascular endothelium is exposed to three types of mechanical forces: blood flow-mediated shear stress, vessel...

... cells (HSPCs) use this pathway to migrate and home to the bone marrow. After selectin-mediated braking, HSPCs migrate on adhesion ligands presented by the vascular endothelium including ICAM-1, VCAM-1 or MAdCAM-1. Here, we report that both the KG1a stem cell line and primary bone marrow CD34 + HSPCs can...

... system. The endothelium can quickly deliver bioactive molecules by regulated exocytosis of its secretory granules, the Weibel−Palade bodies (WPBs). WPBs include proteins that initiate both haemostasis and inflammation, as well those that modulate blood pressure and angiogenesis. WPB formation is driven...

... of von Willebrand factor as tangled strings. Endocytosis Endothelium Weibel-Palade bodies Exocytosis Clathrin Dynamin Many cell types utilise regulated secretion as a means to release premade bioactive material from membranous carriers at the cell surface ( Burgoyne and Morgan, 2003...

...Liane Rauch; Kirsten Hennings; Claudia Trasak; Anja Röder; Barbara Schröder; Friedrich Koch-Nolte; Felix Rivera-Molina; Derek Toomre; Martin Aepfelbacher ABSTRACT Activation and invasion of the vascular endothelium by Staphylococcus aureus is a major cause of sepsis and endocarditis...

... Highlighted Article: The Rho-GEF Trio controls the stability of endothelial cell–cell junctions by locally activating the GTPase Rac1 at VE-cadherin-based junctions. Loss of Trio increases focal adherens junctions and electrical resistance. Trio VE-cadherin GEF Rac1 Endothelium...

... endothelium, the inner lining of blood vessels. Each step of this leukocyte transendothelial migration (TEM) process is regulated by distinct endothelial adhesion receptors such as the intercellular adhesion molecule 1 (ICAM1). Adherent leukocytes exert force on these receptors, which sense mechanical cues...

... Endothelium Sphingosine-1-phosphate receptor-1 Tyrosine phosphorylation Serine phosphorylation Endothelial barrier function Adherens junctions Sphingosine-1-phosphate receptor-1 (S1PR1) is a high affinity G-protein-coupled receptor (GPCR) ligated by the lipid mediator S1P ( Hla, 2004 ; Spiegel...

... and the endothelium. Leukocyte β2-integrins bind to endothelial intercellular adhesion molecule 1 (ICAM-1), which allows leukocyte spreading, crawling and transendothelial migration. Leukocytes scan the vascular endothelium for permissive sites to transmigrate, which suggests that there is apical membrane...

...’ route) or through the inter-endothelial junctions (‘paracellular’ route). What determines the loci or route of breaching events is an open question with important implications for overall barrier regulation. We hypothesized that basic biomechanical properties of the endothelium might serve as crucial...

...Clara Aicart-Ramos; Lucía Sánchez-Ruiloba; Mónica Gómez-Parrizas; Carlos Zaragoza; Teresa Iglesias; Ignacio Rodríguez-Crespo ABSTRACT Vascular endothelial growth factor (VEGF) regulates key functions of the endothelium, such as angiogenesis or vessel repair in processes involving endothelial nitric...

... of Biologists Ltd 2013 Endothelium Fluid shear stress Vascular biology Atherosclerosis is a chronic inflammatory disease of arteries. Cardiovascular disease is responsible for approximately one out of three deaths in the United States, two thirds of which are attributable to atherosclerosis...

... flow Endothelium VEGF Vascular development Zebrafish Blood and lymphatic circulatory networks enable survival and homeostasis ( Adams and Alitalo, 2007 ; Xu and Cleaver, 2011 ). Accordingly, formation of too many, too few, and/or ectopic vascular interconnections, like those between...