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Keywords: Endothelium
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Journal Articles
J Cell Sci (2021) 134 (17): jcs258557.
Published: 02 September 2021
..., thrombin and VEGF can be counteracted by AMPK phosphorylating cingulin at its head domain. Consequential binding of GEF-H1 to tight junctions protects vascular barrier function. Cingulin Tight junction AMPK Vascular barrier function Guanine nucleotide exchange factors Endothelium Vienna...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2021) 134 (7): jcs255653.
Published: 01 April 2021
..., including rolling, adhesion, crawling, diapedesis and sub-endothelial crawling. Nowadays, the role of the endothelium in transmigration is increasingly appreciated. It has been established that leukocyte exit sites on the endothelium and in the pericyte layer are in fact not random but instead may...
Journal Articles
J Cell Sci (2020) 133 (3): jcs239947.
Published: 12 February 2020
.... Mechanotransduction Endothelium Adhesion Integrin YAP Angiogenesis The formation of new blood and lymphatic vessels through angiogenesis is essential for development and vital for tissue regeneration and tumorigenesis ( Gomez-Salinero and Rafii, 2018 ; Potente et al., 2011 ). The luminal side...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (17): jcs227728.
Published: 05 September 2019
... 2019 Summary: Endothelial cell–cell contacts protect tissues from edema and uncontrolled invasion of inflammatory cells. Here, we discuss the emerging role of ubiquitylation of specific proteins controlling endothelial integrity and inflammation. Endothelium Inflammation Ubiquitin...
Journal Articles
J Cell Sci (2018) 131 (12): jcs206920.
Published: 21 June 2018
...Valeria Prystopiuk; Benedikt Fels; Caroline Sophie Simon; Ivan Liashkovich; Dzmitry Pasrednik; Cornelius Kronlage; Roland Wedlich-Söldner; Hans Oberleithner; Johannes Fels ABSTRACT The vascular endothelium is exposed to three types of mechanical forces: blood flow-mediated shear stress, vessel...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (1): jcs205575.
Published: 10 January 2018
... cells (HSPCs) use this pathway to migrate and home to the bone marrow. After selectin-mediated braking, HSPCs migrate on adhesion ligands presented by the vascular endothelium including ICAM-1, VCAM-1 or MAdCAM-1. Here, we report that both the KG1a stem cell line and primary bone marrow CD34 + HSPCs can...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (21): 3611–3617.
Published: 01 November 2017
... system. The endothelium can quickly deliver bioactive molecules by regulated exocytosis of its secretory granules, the Weibel−Palade bodies (WPBs). WPBs include proteins that initiate both haemostasis and inflammation, as well those that modulate blood pressure and angiogenesis. WPB formation is driven...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (15): 2591–2605.
Published: 01 August 2017
... Willebrand factor as tangled strings. Endocytosis Endothelium Weibel-Palade bodies Exocytosis Clathrin Dynamin Many cell types utilise regulated secretion as a means to release premade bioactive material from membranous carriers at the cell surface ( Burgoyne and Morgan, 2003...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (15): 2937–2949.
Published: 01 August 2016
...Liane Rauch; Kirsten Hennings; Claudia Trasak; Anja Röder; Barbara Schröder; Friedrich Koch-Nolte; Felix Rivera-Molina; Derek Toomre; Martin Aepfelbacher ABSTRACT Activation and invasion of the vascular endothelium by Staphylococcus aureus is a major cause of sepsis and endocarditis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (16): 3041–3054.
Published: 15 August 2015
... to thrombin supports our hypothesis that Trio activity is not only crucial for de novo assembly of adherens junctions, but also for reassembly of adherens junctions following inflammatory remodeling of the vascular endothelium. In addition, even apparently stable endothelial monolayers display ongoing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (13): 2221–2230.
Published: 01 July 2015
... endothelium, the inner lining of blood vessels. Each step of this leukocyte transendothelial migration (TEM) process is regulated by distinct endothelial adhesion receptors such as the intercellular adhesion molecule 1 (ICAM1). Adherent leukocytes exert force on these receptors, which sense mechanical cues...
Journal Articles
J Cell Sci (2015) 128 (5): 878–887.
Published: 01 March 2015
... endothelium: role in barrier enhancement.   Cell. Signal.   21 , 1945 – 1960 . 10.1016/j.cellsig.2009.09.002 Zhu   X. , Kim   J. L. , Newcomb   J. R. , Rose   P. E. , Stover   D. R. , Toledo   L. M. , Zhao   H. , Morgenstern   K. A. ( 1999 ). Structural analysis...
Journal Articles
J Cell Sci (2014) 127 (20): 4470–4482.
Published: 15 October 2014
... and the endothelium. Leukocyte β2-integrins bind to endothelial intercellular adhesion molecule 1 (ICAM-1), which allows leukocyte spreading, crawling and transendothelial migration. Leukocytes scan the vascular endothelium for permissive sites to transmigrate, which suggests that there is apical membrane...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2014) 127 (17): 3720–3734.
Published: 01 September 2014
...’ route) or through the inter-endothelial junctions (‘paracellular’ route). What determines the loci or route of breaching events is an open question with important implications for overall barrier regulation. We hypothesized that basic biomechanical properties of the endothelium might serve as crucial...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (15): 3360–3372.
Published: 01 August 2014
...Clara Aicart-Ramos; Lucía Sánchez-Ruiloba; Mónica Gómez-Parrizas; Carlos Zaragoza; Teresa Iglesias; Ignacio Rodríguez-Crespo ABSTRACT Vascular endothelial growth factor (VEGF) regulates key functions of the endothelium, such as angiogenesis or vessel repair in processes involving endothelial nitric...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (22): 5101–5109.
Published: 15 November 2013
... – 472 . 10.1038/35074532 Barakat   A. I. ( 1999 ). Responsiveness of vascular endothelium to shear stress: potential role of ion channels and cellular cytoskeleton.   Int. J. Mol. Med.   4 , 323 – 332 . Barbee   K. A. , Mundel   T. , Lal   R. , Davies   P. F. ( 1995...
Journal Articles
J Cell Sci (2012) 125 (21): 5159–5167.
Published: 01 November 2012
... flow Endothelium VEGF Vascular development Zebrafish Blood and lymphatic circulatory networks enable survival and homeostasis ( Adams and Alitalo, 2007 ; Xu and Cleaver, 2011 ). Accordingly, formation of too many, too few, and/or ectopic vascular interconnections, like those between...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (11): 1936–1942.
Published: 01 June 2011
... 2011 © 2011. 2011 Actin cytoskeleton Atomic force microscopy Bis-oxonol Cell stiffness Electrical membrane potential Endothelium Vascular endothelial cells line the interior surface of blood vessels and are, hence, directly subjected to the physical forces exerted by the flow...
Journal Articles
J Cell Sci (2010) 123 (7): 1073–1080.
Published: 01 April 2010
... et al., 1988 ). Adherens junctions Cell polarity Endothelium Vascular lumen © 2010. 2010 20 1 2010 * Authors for correspondence ( mariagrazia.lampugnani@ifom-ieo-campus.it ; elisabetta.dejana@ifom-ieo-campus.it ) Paraffin sections were deparaffinized according...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (3): 431–440.
Published: 01 February 2010
... to combine the simultaneous display of MLCK activation and protein concentration profiles. To dissect the FRET signal within the underlying endothelium during tumor invasion (Figs 3 and 4 ), a line scan was performed across the central optical plane of the vessel for both the CFP and the YFP channels...
Includes: Multimedia, Supplementary data