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Keywords: Endothelin
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Journal Articles

Endothelin-1 enhances nuclear Ca 2+ transients in atrial myocytes through Ins(1,4,5) P 3 -dependent Ca 2+ release from perinuclear Ca 2+ stores

Jens Kockskämper, Lea Seidlmayer, Stefanie Walther, Kristian Hellenkamp, Lars S. Maier, Burkert Pieske
Journal: Journal of Cell Science
J Cell Sci (2008) 121 (2): 186–195.
https://doi.org/10.1242/jcs.021386
Published: 15 January 2008
... to nuclear Ca 2+ signalling in adult cardiomyocytes remains elusive. We tested the hypothesis that endothelin-1 enhances nuclear Ca 2+ concentration transients (CaTs) in rabbit atrial myocytes through Ins(1,4,5) P 3 -induced Ca 2+ release from perinuclear stores. Cytoplasmic and nuclear CaTs were measured...
View article titled, <span class="search-highlight">Endothelin</span>-1 enhances nuclear Ca 2+ transients in atrial myocytes through Ins(1,4,5) P 3 -dependent Ca 2+ release from perinuclear Ca 2+ stores
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Journal Articles

Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes

Andrew Proven, H. Llewelyn Roderick, Stuart J. Conway, Michael J. Berridge, Jeffrey K. Horton, Stephen J. Capper, Martin D. Bootman
Journal: Journal of Cell Science
J Cell Sci (2006) 119 (16): 3363–3375.
https://doi.org/10.1242/jcs.03073
Published: 15 August 2006
... of Gq-coupled agonists. Endothelin-1 augmented the amplitude of pacing-evoked Ca 2+ signals (positive inotropy), and caused an increasing frequency of spontaneous diastolic Ca 2+ -release transients. Both effects of endothelin-1 were blocked by an antagonist of phospholipase C, suggesting that Ins(1,4,5...
View article titled, Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of <span class="search-highlight">endothelin</span>-1 on ventricular cardiac myocytes
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Includes: Supplementary data