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Keywords: Endothelial cells
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Journal Articles
J Cell Sci (2022) 135 (2): jcs259104.
Published: 26 January 2022
...Francois Chesnais; Jonas Hue; Errin Roy; Marco Branco; Ruby Stokes; Aize Pellon; Juliette Le Caillec; Eyad Elbahtety; Matteo Battilocchi; Davide Danovi; Lorenzo Veschini ABSTRACT Endothelial cells (ECs) are heterogeneous across and within tissues, reflecting distinct, specialised functions. EC...
Includes: Supplementary data
Journal Articles
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Cell Migration
J Cell Sci (2021) 134 (21): jcs258690.
Published: 4 November 2021
... in which human endothelial cells were cultured in a tube-like lumen in a collagen-1 matrix. The vessels are leak tight, creating a barrier for molecules and leukocytes. Addition of inflammatory cytokine TNF-α (also known as TNF) caused vasoconstriction, actin remodelling and upregulation of ICAM-1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs254920.
Published: 2 August 2021
...Kiyomi Tsuji-Tamura; Saori Morino-Koga; Shingo Suzuki; Minetaro Ogawa ABSTRACT Elongation of vascular endothelial cells (ECs) is an important process in angiogenesis; however, the molecular mechanisms remain unknown. The actin-crosslinking protein TAGLN (transgelin, also known as SM22 or SM22α...
Includes: Supplementary data
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Membrane Trafficking
J Cell Sci (2021) 134 (13): jcs246892.
Published: 12 July 2021
...) and macropinocytosis (MP), whereas in human embryonic stem cells (hESCs) internalisation occurs via CME. We further show that hESCs are devoid of MP, which becomes functional upon differentiation towards endothelial cells through mesoderm mediators. Our results reveal, for the first time, that MP is an internalisation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (18): jcs239889.
Published: 16 September 2020
... modulate endothelial cell structure and function. Finally, we discuss the pathological ramifications of the biophysical properties of the vascular BM and highlight the potential of mimicking BM topography to improve the design of implantable endovascular devices and advance the burgeoning field of vascular...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (14): jcs239715.
Published: 21 July 2020
...Paul D. Upton; John E. S. Park; Patricia M. De Souza; Rachel J. Davies; Mark J. D. Griffiths; Stephen J. Wort; Nicholas W. Morrell ABSTRACT Bone morphogenetic protein 9 (BMP9) and BMP10 are circulating ligands that mediate endothelial cell (EC) protection via complexes of the type I receptor ALK1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (9): jcs237776.
Published: 14 May 2020
...Shanshan Qin; Dan N. Predescu; Monal Patel; Patrick Drazkowski; Balaji Ganesh; Sanda A. Predescu ABSTRACT The sex-biased disease pulmonary arterial hypertension (PAH) is characterized by the proliferation and overgrowth of dysfunctional pulmonary artery endothelial cells (PAECs). During...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (1): jcs232702.
Published: 2 January 2020
.... Exploiting mechanically tunable nano-patterned substrates, and peptidomimetic ligands designed to selectively bind corresponding integrins, we report that focal adhesions (FAs) of endothelial cells assembled on α 5 β 1 integrin-selective substrates rapidly recruit α v β 3 integrins, but not vice versa...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (7): jcs225615.
Published: 3 April 2019
... of TNF receptor superfamily members, such as the lymphotoxin-β receptor (LTβR), and is implicated in pathological angiogenesis associated with chronic inflammation and cancer. Here, we identify a previously unrecognized role of the LTβR–NIK axis during inflammatory activation of human endothelial cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (8): 1365–1378.
Published: 15 April 2017
.... Additionally, PDGF-D induced translocation of NRP1 to cell–cell junctions in endothelial cells, independently of PDGFRβ, altering the availability of NRP1 for VEGF-A–VEGFR2 signaling. PDGF-D showed differential effects on pericyte behavior in ex vivo sprouting assays compared to PDGF-B. Furthermore, PDGF-D...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (13): 2586–2598.
Published: 1 July 2016
... studied in monocytic cells, but much less is known about those formed in other lineages. In this study, we characterise podosomes in capillary-derived microvascular endothelial cells. We identify two types of podosomes: constitutive podosomes that form in the absence of specific stimulation and induced...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (1): 206–218.
Published: 1 January 2016
...Andreas Benn; Clara Bredow; Isabel Casanova; Slobodan Vukičević; Petra Knaus ABSTRACT Several vascular disorders, such as aberrant angiogenesis, atherosclerosis and pulmonary hypertension, have been linked to dysfunctional BMP signaling. Vascular hyperpermeability via distortion of endothelial cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (9): 1683–1695.
Published: 1 May 2015
...Hiyori Abiko; Sachiko Fujiwara; Kazumasa Ohashi; Ryuichi Hiatari; Toshiya Mashiko; Naoya Sakamoto; Masaaki Sato; Kensaku Mizuno Cyclic stretch is an artificial model of mechanical force loading, which induces the reorientation of vascular endothelial cells and their stress fibers in a direction...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (5): 863–877.
Published: 1 March 2015
..., the mechanisms that regulate the decision to disassemble or to grow nascent adhesions are not fully understood. Here we show that, in endothelial cells, 3-phosphoinositide-dependent protein kinase 1 (PDK1) promotes focal adhesion (FA) turnover by controlling endocytosis of integrin αvβ3 in a PI3K-dependent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (4): 695–705.
Published: 15 February 2015
... and Pyk2 signaling. Finally, we found that IL-4 induces the late expression of endogenous FRNK. In summary, FRNK represents a novel mechanism to negatively regulate IL-4-mediated inflammation. Interactions between endothelial cells and freshly isolated human eosinophils were examined under flow...
Journal Articles
J Cell Sci (2015) 128 (3): 576–588.
Published: 1 February 2015
...Gong Feng; David P. Sullivan; Fei Han; William A. Muller ABSTRACT The lateral border recycling compartment (LBRC) is a reticulum of perijunctional tubulovesicular membrane that is continuous with the plasmalemma of endothelial cells and is essential for efficient transendothelial migration (TEM...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (1): 70–80.
Published: 1 January 2015
... demonstrate that miR-34a expression in endothelial cells was downregulated by atheroprotective physiological high shear stress (HSS), whereas it was upregulated by atheroprone oscillatory shear stress (OSS). Blockade of endogenous miR-34a dramatically decreased basal vascular cell adhesion molecule-1 (VCAM-1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (16): 3756–3769.
Published: 15 August 2013
... to stabilize nectin at endothelial junctions and to preserve endothelial integrity under vascular flow. Actin cytoskeleton Afadin Cell–cell junctions Drebrin Endothelial cells Nectin Integrity of the endothelial monolayer is essential for the maintenance of the blood-vessel barrier. Opening...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (14): 3082–3094.
Published: 15 July 2013
... are growth factors known to play a key role in vascular development. The BMP pathway is controlled by extracellular BMP modulators such as BMP endothelial cell precursor derived regulator (BMPER), which we reported previously acts proangiogenically on endothelial cells in a concentration-dependent manner...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (6): 1392–1405.
Published: 15 March 2013
... and pro-differentiation signaling pathways of endothelial cells (EC). However, the contribution of endoglin to these TGFβ activities, and more specifically modulation of EC phenotype, remains elusive. Mutations in endoglin cause hereditary hemorrhagic telangiectasia-1 in humans. The Eng+/− mice are viable...
Includes: Supplementary data