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Keywords: Endothelial cells
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Journal Articles
Journal Articles
J Cell Sci (2023) 136 (10): jcs260657.
Published: 25 May 2023
... or UBE2D2 in endothelial cells caused a rise in steady-state VEGFR2 levels. This rise in plasma membrane VEGFR2 levels impacted on VEGF-A-stimulated signalling, with increased activation of canonical MAPK, phospholipase Cγ1 and Akt pathways. Analysis of biosynthetic VEGFR2 is consistent with a role...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2023) 136 (2): jcs260442.
Published: 31 January 2023
... of biomechanical properties of the cellular environment in Notch signaling in general is still poorly understood. During angiogenesis, differentiation of endothelial cells into tip and stalk cells is regulated by Notch signaling, and remodeling of the extracellular matrix occurs. We investigated the influence...
Includes: Supplementary data
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Cell migration
J Cell Sci (2021) 134 (21): jcs258690.
Published: 4 November 2021
... in which human endothelial cells were cultured in a tube-like lumen in a collagen-1 matrix. The vessels are leak tight, creating a barrier for molecules and leukocytes. Addition of inflammatory cytokine TNF-α (also known as TNF) caused vasoconstriction, actin remodelling and upregulation of ICAM-1...
Includes: Supplementary data
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Membrane trafficking
J Cell Sci (2021) 134 (13): jcs246892.
Published: 12 July 2021
...) and macropinocytosis (MP), whereas in human embryonic stem cells (hESCs) internalisation occurs via CME. We further show that hESCs are devoid of MP, which becomes functional upon differentiation towards endothelial cells through mesoderm mediators. Our results reveal, for the first time, that MP is an internalisation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (18): jcs239889.
Published: 16 September 2020
... modulate endothelial cell structure and function. Finally, we discuss the pathological ramifications of the biophysical properties of the vascular BM and highlight the potential of mimicking BM topography to improve the design of implantable endovascular devices and advance the burgeoning field of vascular...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2020) 133 (1): jcs232702.
Published: 2 January 2020
.... Exploiting mechanically tunable nano-patterned substrates, and peptidomimetic ligands designed to selectively bind corresponding integrins, we report that focal adhesions (FAs) of endothelial cells assembled on α 5 β 1 integrin-selective substrates rapidly recruit α v β 3 integrins, but not vice versa...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (7): jcs225615.
Published: 3 April 2019
... of TNF receptor superfamily members, such as the lymphotoxin-β receptor (LTβR), and is implicated in pathological angiogenesis associated with chronic inflammation and cancer. Here, we identify a previously unrecognized role of the LTβR–NIK axis during inflammatory activation of human endothelial cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (8): 1365–1378.
Published: 15 April 2017
.... Additionally, PDGF-D induced translocation of NRP1 to cell–cell junctions in endothelial cells, independently of PDGFRβ, altering the availability of NRP1 for VEGF-A–VEGFR2 signaling. PDGF-D showed differential effects on pericyte behavior in ex vivo sprouting assays compared to PDGF-B. Furthermore, PDGF-D...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2016) 129 (1): 206–218.
Published: 1 January 2016
...Andreas Benn; Clara Bredow; Isabel Casanova; Slobodan Vukičević; Petra Knaus ABSTRACT Several vascular disorders, such as aberrant angiogenesis, atherosclerosis and pulmonary hypertension, have been linked to dysfunctional BMP signaling. Vascular hyperpermeability via distortion of endothelial cell...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2015) 128 (5): 863–877.
Published: 1 March 2015
..., the mechanisms that regulate the decision to disassemble or to grow nascent adhesions are not fully understood. Here we show that, in endothelial cells, 3-phosphoinositide-dependent protein kinase 1 (PDK1) promotes focal adhesion (FA) turnover by controlling endocytosis of integrin αvβ3 in a PI3K-dependent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (4): 695–705.
Published: 15 February 2015
... no competing or financial interests. 23 05 2014 1 12 2014 © 2015. Published by The Company of Biologists Ltd 2015 Cell adhesion Endothelial cells Inflammation Leukocyte trafficking Chronic inflammatory diseases are characterized by inappropriate and unregulated infiltration...
Journal Articles
J Cell Sci (2015) 128 (3): 576–588.
Published: 1 February 2015
...Gong Feng; David P. Sullivan; Fei Han; William A. Muller ABSTRACT The lateral border recycling compartment (LBRC) is a reticulum of perijunctional tubulovesicular membrane that is continuous with the plasmalemma of endothelial cells and is essential for efficient transendothelial migration (TEM...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (1): 70–80.
Published: 1 January 2015
... demonstrate that miR-34a expression in endothelial cells was downregulated by atheroprotective physiological high shear stress (HSS), whereas it was upregulated by atheroprone oscillatory shear stress (OSS). Blockade of endogenous miR-34a dramatically decreased basal vascular cell adhesion molecule-1 (VCAM-1...
Includes: Supplementary data