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Keywords: Endosomal fusion
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Journal Articles
Invariant chain regulates endosomal fusion and maturation through an interaction with the SNARE Vti1b
Available to PurchaseAzzurra Margiotta, Dominik M. Frei, Ingrid Hegnes Sendstad, Lennert Janssen, Jacques Neefjes, Oddmund Bakke
Journal:
Journal of Cell Science
J Cell Sci (2020) 133 (19): jcs244624.
Published: 9 October 2020
.../ Summary: Invariant chain (CD74) interacts with the SNARE Vti1b. This interaction is essential for invariant chain to delay endosomal maturation, thereby creating a pathway for slower antigen processing and antigen loading. Endosomal fusion Ii Vti1b SNAREs MHCII The major...
Includes: Supplementary data
Journal Articles
Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L
Available to PurchaseRik van der Kant, Alexander Fish, Lennert Janssen, Hans Janssen, Sabine Krom, Nataschja Ho, Thijn Brummelkamp, Jan Carette, Nuno Rocha, Jacques Neefjes
Journal:
Journal of Cell Science
J Cell Sci (2013) 126 (15): 3462–3474.
Published: 1 August 2013
... and autophagosome. Defects in lysosomal dynamics cause severe neurodegenerative and developmental diseases, such as Niemann–Pick type C disease and ARC syndrome, yet little is known about the regulation of late endosomal fusion in a mammalian system. Mammalian endosomes destined for fusion need to be transported...
Includes: Supplementary data
