.... , Hatokova , Z. , Evinova , A. , Cibulka , M. and Racay , P. ( 2021 ). Differential impact of imipramine on Thapsigargin- and tunicamycin-induced endoplasmic reticulum stress and mitochondrial dysfunction in neuroblastoma SH-SY5Y cells . Eur. J. Pharmacol. 902 , 174073 . 10.1016...

... on pharyngeal arch deficiency and found that pharyngeal arches in hspa8 mutant embryos exhibited induction of endoplasmic reticulum stress and activation of the unfolded protein response via the Perk/p-eIF2α/Atf4 signaling cascade. Inhibition of Perk/p-eIF2α/Atf4 signaling rescued the developmental deficiency...

... homeostasis and discusses the sensing mechanism and its contribution to metabolic diseases. Endoplasmic reticulum stress Unfolded protein response Lipid perturbation Phospholipids Metabolic diseases Nanyang Technological University 10.13039/501100001475 Human Frontier Science...

... Article: Deficiency of the protein kinase Tak1 protects cells against endoplasmic reticulum stress through activation of de novo lipogenesis, which prevents leptin resistance in the hypothalamus and hyperphagic obesity. TAK1 Endoplasmic reticulum stress Leptin Hypothalamus Obesity...

... reticulum Endoplasmic reticulum stress Mitochondria Protein disulfide isomerase Reactive oxygen species Unfolded protein response A fundamental property of Metazoa is their ability to send, receive and decode signals between neighboring tissues and the extracellular environment...

... for correspondence ( [email protected] ) 23 05 2013 © 2013. Published by The Company of Biologists Ltd 2013 Endoplasmic reticulum stress IL-4/IL-13 signaling Gene suppression C/EBPβ Regulation of lipid metabolism upon ER stress provides stark evidence that coordinated gene...

... 2011. 2011 Ca 2+ Metabolism Mitochondria Mitofusin 2 (Mfn2) Unfolded protein response (UPR) Endoplasmic reticulum stress Endoplasmic reticulum (ER) stress is a cellular state in which the folding capacity of the ER is overwhelmed owing to an increase in protein load or disruption...

.... * These authors contributed equally to this work ‡ Author for correspondence ( [email protected] ) 2 6 2010 © 2010. 2010 CHK1 Cell cycle Endoplasmic reticulum stress PERK Secreted proteins are folded, modified and assembled into multi-protein complexes in the endoplasmic reticulum...

... al. ( 2004 ). BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Mol. Cell 15 , 355 -366. Chen, Q., Chen, J., Sun, T., Shen, J., Shen, X. and Jiang, H. ( 2004 ). A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist. Anal...

... to this work 22 4 2008 © The Company of Biologists Limited 2008 2008 Pancreatic β-cell Islet Endoplasmic reticulum stress Fatty acid Oleate Palmitate Lipotoxicity Apoptosis Type 2 diabetes Insulin deficiency is present early in the pathogenesis of type 2 diabetes (T2D...

... and disorders linked to ER dysfunction. * Author for correspondence (e-mail: [email protected] ) 24 9 2004 © The Company of Biologists Limited 2005 2005 Valproate Endoplasmic reticulum stress Apoptosis Lipid accumulation Glycogen synthase kinase In eukaryotic...