.... , Brighouse , A. , Gabernet-Castello , C. , Field , M. C. and Dacks , J. B. ( 2012 ). Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases . J. Cell Sci. 125 , 2500 - 2508 . 10.1242/jcs.101378 Essid , M. , Gopaldass , N...

... leukemia (AML). Owing to its constitutive kinase activity FLT3 ITD partially accumulates at endomembranes, a feature shared with other disease-associated, mutated receptor tyrosine kinases. Because Ras proteins also transit through endomembranes we have investigated the possible existence...

...Joel B. Dacks; Mark C. Field The emergence of an endomembrane system was a crucial stage in the prokaryote-to-eukaryote evolutionary transition. Recent genomic and molecular evolutionary analyses have provided insight into how this critical system arrived at its modern configuration. The apparent...

... unknown. Here, we have studied the potential roles of the cytoskeleton and endomembrane system in the localisation of PIN proteins. Immunocytochemistry and image analysis on root cells from Arabidopsis thaliana and maize showed that 10-30% of the intracellular PIN proteins mapped to the Golgi network...