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Keywords: Endocycles
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Journal Articles
In collection:
Cell cycle
Journal:
Journal of Cell Science
J Cell Sci (2024) 137 (3): jcs261364.
Published: 13 February 2024
... that dysregulation of CycB:CDK disrupts strict alternation of the G1-S and M-G1 switches. Inhibition of CycB:CDK results in Cdc20-independent Cdh1 ‘endocycles’, and sustained activity of CycB:CDK drives Cdh1-independent Cdc20 endocycles. Our model provides a mechanistic explanation for how whole-genome doubling can...
Includes: Supplementary data
