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Keywords: Emerin
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Journal Articles
J Cell Sci (2017) 130 (13): 2111–2118.
Published: 01 July 2017
...; but how cells sense and transduce mechanical cues to modulate SRF−Mkl1-dependent gene expression is not well understood. Here, we demonstrate that the nuclear lamina-associated inner nuclear membrane protein Emerin stimulates SRF−Mkl1-dependent gene activity in a substrate stiffness-dependent manner...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (9): 1781–1791.
Published: 01 May 2016
... that the EDMD mutation L535P disrupts the nuclear mechanical response specifically in muscle nuclei. Inhibiting lamin prenylation rescued the mechanical response of the EDMD nuclei, reversed the muscle phenotypes and led to normal motility. The LINC complex and emerin were also required to regulate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (3): 502–516.
Published: 01 February 2016
...Janine Pfaff; Jhon Rivera Monroy; Cara Jamieson; Kalpana Rajanala; Fabio Vilardi; Blanche Schwappach; Ralph H. Kehlenbach ABSTRACT Emerin is a tail-anchored protein that is found predominantly at the inner nuclear membrane (INM), where it associates with components of the nuclear lamina. Mutations...
Journal Articles
J Cell Sci (2015) 128 (6): 1090–1096.
Published: 15 March 2015
...Adela Morales-Martínez; Agnieszka Dobrzynska; Peter Askjaer ABSTRACT The inner nuclear membrane proteins emerin and LEMD2 have both overlapping and separate functions in regulation of nuclear organization, gene expression and cell differentiation. We report here that emerin (EMR-1) and LEM domain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (18): 3956–3969.
Published: 15 September 2014
...Jason M. Berk; Dan N. Simon; Clifton R. Jenkins-Houk; Jason W. Westerbeck; Line M. Grønning-Wang; Cathrine R. Carlson; Katherine L. Wilson ABSTRACT Emerin is a conserved membrane component of nuclear lamina structure. Here, we report an advance in understanding the molecular basis of emerin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (12): 2831–2836.
Published: 15 June 2012
... also causes a nuclear envelope defect. Transport of nucleoporins (Nups) and emerin (EMD) to the nuclear envelope is blocked, resulting in their sequestration in dilated cytoplasmic membranes. Simultaneous overexpression of the FFAT motif (two phenylalanine residues in an acidic track) antagonizes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (10): 1691–1702.
Published: 15 May 2011
...Zinaida Dedeic; Maureen Cetera; Tatiana V. Cohen; James M. Holaska X-linked Emery–Dreifuss muscular dystrophy (X-EDMD) is caused by mutations in the inner nuclear membrane protein emerin. Previous studies have shown that emerin binds to and inhibits the activity of LIM domain only 7 (Lmo7...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (9): 1433–1444.
Published: 01 May 2011
... show that 4.1R, the nuclear envelope protein emerin and the intermediate filament protein lamin A/C co-immunoprecipitate, and that 4.1R-specific depletion in human cells by RNA interference produces nuclear dysmorphology and selective mislocalization of proteins from several nuclear subcompartments...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (22): 4099–4108.
Published: 15 November 2009
... lamins than in cells from wild-type mice. Knockdown of Sun2 also increased the mobility of a short, chimeric form of nesprin-2 giant (mini-nesprin-2G), whereas the lack of emerin did not affect the mobility of Sun1, Sun2 or mini-nesprin-2G. Fluorescence resonance energy transfer experiments showed Sun1...
Journal Articles
J Cell Sci (2009) 122 (20): 3780–3790.
Published: 15 October 2009
...Kathryn E. Tifft; Katherine A. Bradbury; Katherine L. Wilson X-linked recessive Emery-Dreifuss muscular dystrophy (EDMD) is caused by loss of emerin, a nuclear-membrane protein with roles in nuclear architecture, gene regulation and signaling. Phosphoproteomic studies have identified 13 sites...
Journal Articles
J Cell Sci (2008) 121 (15): 2540–2554.
Published: 01 August 2008
... in human cells showed that barrier-to-autointegration factor (BAF), a DNA-binding protein, assembled first at the distinct `core' region of the telophase chromosome and formed an immobile complex by directly binding with other core-localizing NE proteins, such as lamin A and emerin. Correlative light...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (4): 536–548.
Published: 15 February 2008
... termini reside cyto- or nucleoplasmically. Nuclear envelope targeting of LUMA mainly depends on the membrane spans. LUMA's transmembrane domains also promote homooligomerization. LUMA binds A- and B-type lamins and depends on A-type lamins for its INM localization. Furthermore, it interacts with emerin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (12): 1967–1977.
Published: 15 June 2007
... 2007 BAF Nuclear envelope Chromatin Emerin Lamin A Aging Barrier-to-autointegration factor (BAF), a ∼10 kDa dsDNA-binding protein, was first discovered as a host component of retroviral pre-integration complexes that facilitated integrase-mediated integration into target DNA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (21): 4442–4451.
Published: 01 November 2006
... on the nuclear surface of HeLaS3 cells in early cell-cycle stages. Such `pore-free islands' gradually become dispersed in G1-S phase. Surprisingly, the islands are enriched with inner nuclear membrane proteins lamin A/C and emerin, but exclude lamin B. Lamin-A/C-enriched pore-free islands were also observed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (13): 2704–2714.
Published: 01 July 2006
... A cDNAs with disease-causing mutations were expressed in HeLa cells. The inner nuclear membrane protein emerin was mislocalised upon expression of the muscular dystrophy mutants G232E, Q294P or R386K, which aberrantly assembled into nuclear aggregates, or upon expression of mutants causing progeria...
Journal Articles
J Cell Sci (2005) 118 (15): 3419–3430.
Published: 01 August 2005
... The Company of Biologists Limited 2005 2005 Emerin Enaptin Lamin A/C NUANCE SUN domain Syne Furthermore, this linkage may also account for the close proximity of the two NE membranes. Recent evidence implicates TorsinA in connecting the NE to the cytoskeleton. Torsin A an AAA+ ATPase...
Journal Articles
J Cell Sci (2004) 117 (7): 979–987.
Published: 01 March 2004
... knowledge, we propose lamin-associated complexes with multiple components relevant to nuclear structure (e.g. emerin, nesprin 1α, actin) or signaling and gene regulation (e.g. LAP2α, retinoblastoma, E2F-DP heterodimers, genes) as `food for thought'. Testing these ideas will deepen our understanding...
Journal Articles
J Cell Sci (2002) 115 (2): 341–354.
Published: 15 January 2002
...Elizabeth A. L. Fairley; Andrew Riddell; Juliet A. Ellis; John Kendrick-Jones Emerin is the nuclear membrane protein defective in X-linked Emery-Dreifuss muscular dystrophy (X-EDMD). The majority of X-EDMD patients have no detectable emerin. However, there are cases that produce mutant forms...
Journal Articles
J Cell Sci (2001) 114 (24): 4447–4457.
Published: 15 December 2001
... cardiomyopathy (L85R and N195K) and autosomal dominant Emery-Dreifuss muscular dystrophy (L530P) modify the assembly properties of lamins A and C and cause partial mislocalization of emerin, an inner nuclear membrane protein, in HeLa cells. At the same time, these mutant lamins interfere with the targeting...
Journal Articles
J Cell Sci (2001) 114 (14): 2577–2590.
Published: 15 July 2001
...O. Anthony Vaughan; Mauricio Alvarez-Reyes; Joanna M. Bridger; Jos L. V. Broers; Frans C. S. Ramaekers; Manfred Wehnert; Glen E. Morris; William G. F. Whitfield; Christopher J. Hutchison Physical interactions between lamins and emerin were investigated by co-immunoprecipitation of in vitro...