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Keywords: Embryo
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Journal Articles
J Cell Sci jcs.258973.
Published: 11 October 2021
... plus and minus ends. In syncytial Drosophila embryos Rho1 signaling is high between actin caps, i. e. the cortical intercap region. Capping protein binds to free plus ends of F-actin to prevent elongation of the filament. Capping protein has served as a marker to visualize the distribution of F-actin...
Journal Articles
J Cell Sci (2020) 133 (23): jcs243238.
Published: 07 December 2020
.... Compaction of early embryos is based on the accumulation of E-cadherin (Cdh1) at cell-contacted membranes. However, how AGS3 regulates the transport of Cdh1 to the plasma membrane remains undetermined. To investigate this, AGS3 was knocked out using the Cas9-sgRNA system. Both trans-Golgi network protein 46...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (10): jcs240168.
Published: 22 May 2020
...Bipasha Dey; Richa Rikhy ABSTRACT Cell shape morphogenesis, from spherical to polygonal, occurs in epithelial cell formation in metazoan embryogenesis. In syncytial Drosophila embryos, the plasma membrane incompletely surrounds each nucleus and is organized as a polygonal epithelial-like array...
Includes: Supplementary data
Journal Articles
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J Cell Sci (2019) 132 (19): jcs231357.
Published: 09 October 2019
... forces during cytokinesis is not well understood. Here we show that, under mechanical stress, cortical actomyosin flow can switch polarization during cytokinesis in the C. elegans embryo. In unstressed embryos, longitudinal cortical flow contributes to contractile ring formation, while rotational...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (14): 2468–2481.
Published: 15 July 2015
.... To investigate this apparent contradiction, we applied cytoskeletal inhibitors to mouse embryos in culture. Preventing actomyosin cross-linking, F-actin assembly or myosin II contractile activity did not disrupt spinal closure. In contrast, inhibiting Rho kinase (ROCK, for which there are two isoforms ROCK1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (4): 804–814.
Published: 15 February 2015
...Youn-Jung Kang; Miranda Lees; Laura C. Matthews; Susan J. Kimber; Karen Forbes; John D. Aplin ABSTRACT Successful implantation requires the synchronization of viable embryonic development with endometrial receptivity. The mechanisms allowing for the initiation of crosstalk between the embryo...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (13): 3039–3049.
Published: 01 July 2012
.... elegans developing embryos.   Biophys. J.   90 , 4712 – 4719 . 10.1529/biophysj.105.080606 David   D. J. , Tishkina   A. , Harris   T. J. ( 2010 ). The PAR complex regulates pulsed actomyosin contractions during amnioserosa apical constriction in Drosophila.   Development   137 , 1645...
Journal Articles
J Cell Sci (2011) 124 (12): 2086–2095.
Published: 15 June 2011
... nucleation. We conclude that F-actin polymerization in bulk cytoplasm is cell cycle regulated in early vertebrate embryos and discuss possible biological functions of this regulation. * Author for correspondence ( christine_field@hms.harvard.edu ) 2 2 2011 © 2011. 2011 Actin...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (13): 2179–2189.
Published: 01 July 2010
...Whitney M. Jones; Anna T. Chao; Michael Zavortink; Robert Saint; Amy Bejsovec Wg/Wnt signals specify cell fates in both invertebrate and vertebrate embryos and maintain stem-cell populations in many adult tissues. Deregulation of the Wnt pathway can transform cells to a proliferative fate, leading...
Journal Articles
J Cell Sci (2009) 122 (13): 2197–2207.
Published: 01 July 2009
... regulator of the TGFβ signaling pathway. Mechanistically, Rock2 binds to and accelerates the lysosomal degradation of TGFβ type I receptors internalized from the cell surface in mammalian cells. The inhibitory effect of Rock2 on TGFβ signaling requires its kinase activity. In zebrafish embryos, injection...
Journal Articles
J Cell Sci (2007) 120 (18): 3179–3187.
Published: 15 September 2007
...), the single Caenorhabditis elegans homolog of mammalian fidgetin and fidgetin-like 1 AAA-ATPases, controls progression through mitosis in the germ line and the early embryo. Loss of figl-1 function leads to the accumulation of mitotic nuclei in the proliferative zone of the germ line, resulting in sterility...
Journal Articles
J Cell Sci (2006) 119 (10): 2048–2055.
Published: 15 May 2006
...Rosemary C. Manser; Franchesca D. Houghton Previous studies have demonstrated a role for the signalling agent nitric oxide in regulating preimplantation embryo development. We have now investigated the biochemical mode of action of nitric oxide in mouse embryos in terms of mitochondrial function...
Journal Articles
J Cell Sci (2005) 118 (15): 3305–3315.
Published: 01 August 2005
... ) * These authors contributed equally to this work ‡ Present address: MedImmune Vaccines, Santa Clara, CA 95054, USA 25 4 2005 © The Company of Biologists Limited 2005 2005 Drosophila Checkpoints Chk1 grapes Embryo Mitosis Metaphase-anaphase transition Eukaryotic cells...
Journal Articles
J Cell Sci (2003) 116 (18): 3713–3720.
Published: 15 September 2003
... report the identification of several markers of morphological remodeling, or lack thereof, of mouse cumulus cell nuclei after transplantation into oocytes. Notably, nuclear transplant mouse embryos exhibit nuclear assembly of the differentiated cell-specific A-type lamins at the one-cell stage...
Journal Articles
J Cell Sci (2003) 116 (16): 3251–3257.
Published: 15 August 2003
... and pumps for the ability to induce defects in heart looping, gut coiling and gall bladder position in early Xenopus embryos revealed that several compounds that cause laterality defects inhibit the H + /K + -ATPase, a pump that exchanges H + and K + across membranes ( Levin et al., 2002 ). The window...
Journal Articles
J Cell Sci (2002) 115 (23): 4577–4586.
Published: 01 December 2002
... in restricting synthesis of replication-dependent histones to S-phase. In contrast to somatic cells,replication-dependent histone mRNAs accumulate and are translated independently of DNA replication in oocytes and early embryos. We report here that SLBP expression and activity also differ in mouse oocytes...
Journal Articles
J Cell Sci (2002) 115 (15): 3171–3180.
Published: 01 August 2002
..., embryos and cells using primers spanning the fourth transmembrane domain (TM4) and adjacent C-terminal region revealed two products. The larger and predominant product corresponded in sequence to canonical occludin (TM4 + ), while the smaller product exhibited a 162 bp deletion encoding the entire TM4...
Journal Articles
J Cell Sci (2001) 114 (20): 3607–3618.
Published: 15 October 2001
... Drosophila embryo nuclear structure at the syncytial stage of early development using field emission scanning electron microscopy (FESEM), a high resolution surface imaging technique, and transmission electron microscopy. Nuclear division in syncytial embryos is characterized by semi-closed mitosis, during...
Journal Articles
J Cell Sci (1988) 1988 (Supplement_10): 11–27.
Published: 01 February 1988
... be obtained from outgrowths of blastocysts in vitro are also discussed. J . Cell Sci. Suppl. 10, 11-27 (1988) Printed in Great Britain © The Company o f Biologists Limited 1988 11 Multi-lineage stem cells in the mammalian embryo R . L . G A R D N E R AND R. S . P. B E D D IN G T O N Imperial Cancer Research...