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Keywords: ESCRT
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Journal Articles
Journal Articles
J Cell Sci (2023) 136 (21): jcs261385.
Published: 13 November 2023
...Sarah R. Barger; Lauren Penfield; Shirin Bahmanyar ABSTRACT Barrier-to-autointegration factor (BAF) protein is a DNA-binding protein that crosslinks chromatin to allow mitotic nuclear envelope (NE) assembly. The LAP2-emerin-MAN1 (LEM)-domain protein LEMD2 and ESCRT-II/III hybrid protein CHMP7 close...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (15): jcs261097.
Published: 10 August 2023
... is mediated by the endosomal sorting complex required for transport (ESCRT), a conserved membrane remodelling machinery. The midbody organiser CEP55 recruits early acting ESCRT factors such as ESCRT-I and ALIX (also known as PDCD6IP), which subsequently initiate the formation of ESCRT-III polymers that sever...
Includes: Supplementary data
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Membrane trafficking
J Cell Sci (2021) 134 (21): jcs259192.
Published: 4 November 2021
...Gabrielle Parkinson; Peristera Roboti; Ling Zhang; Sandra Taylor; Philip Woodman ABSTRACT His domain protein tyrosine phosphatase (HD-PTP; also known as PTPN23) collaborates with endosomal sorting complexes required for transport (ESCRTs) to sort endosomal cargo into intralumenal vesicles, forming...
Includes: Supplementary data
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Journal Articles
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In collection:
Membrane trafficking
J Cell Sci (2020) 133 (18): jcs240333.
Published: 16 September 2020
...Mark Remec Pavlin; James H. Hurley ABSTRACT The endosomal sorting complexes required for transport (ESCRTs) I, -II and –III, and their associated factors are a collection of ∼20 proteins in yeast and ∼30 in mammals, responsible for severing membrane necks in processes that range from multivesicular...
Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2019) 132 (19): jcs229179.
Published: 3 October 2019
... with an ESCRT-I component, Vps37B. Taken together, our observations reveal an indispensable role of SH3YL1 in MVB sorting and EGFR degradation mediated by ESCRT complexes. * Present address: Department of Biochemical Pathophysiology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs232868.
Published: 15 August 2019
... membrane has to be strictly controlled. Heteromeric endosomal sorting complexes required for transport (ESCRTs) are responsible for mediating the post-translational degradation of endocytosed plasma membrane proteins in eukaryotes and are essential both in animals and plants. ESCRTs bind and sort...
Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2019) 132 (4): jcs217968.
Published: 3 August 2018
...Nicola De Franceschi; Maryam Alqabandi; Nolwenn Miguet; Christophe Caillat; Stephanie Mangenot; Winfried Weissenhorn; Patricia Bassereau ABSTRACT Endosomal sorting complexes required for transport (ESCRT)-III family proteins catalyze membrane remodeling processes that stabilize and constrict...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (11): jcs213876.
Published: 11 June 2018
... homeostasis. ESCRT-, V-ATPase- and vacuole protein sorting-mutants negatively affect LD consumption, independent of lipophagy. Loss of ESCRT function leads to the accumulation of LD-derived diacylglycerol (DAG), preventing its conversion into phosphatidic acid (PA) and membrane lipids. In addition, channeling...
Includes: Supplementary data
Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2018) 131 (1): jcs211367.
Published: 4 January 2018
... activated. Here, we demonstrate that inactivation of the ESCRT-III causes dramatic accumulation of Smo in the ESCRT-III/MVB compartment, and subsequent activation of Hh signaling. In contrast, inactivation of ESCRTs 0–II induces mild Smo accumulation in the ESCRT-III/MVB compartment. We provide evidence...
Includes: Supplementary data
Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2015) 128 (14): 2520–2528.
Published: 15 July 2015
... to lysosomes for degradation. Here, we show that APP localizes to the ILVs of a subset of MVBs that also traffic EGF receptor (EGFR), and that it is delivered to lysosomes for degradation. Depletion of the endosomal sorting complexes required for transport (ESCRT) components, Hrs (also known as Hgs) or Tsg101...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (4): 706–716.
Published: 15 February 2015
... protein Btn2. * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing or financial interests. 17 07 2014 5 12 2014 © 2015. Published by The Company of Biologists Ltd 2015 Epsin Multivesicular body Ubiquitin ESCRT...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2013) 126 (2): 645–656.
Published: 15 January 2013
... of the gene that encodes the ESCRT-III component Shrub, which is an interaction partner of Lgd. We further show that activation of Notch appears to be a general consequence of loss of lgd function. In addition, electron microscopy of lgd cells revealed that they contain enlarged multi-vesicular bodies...
Includes: Supplementary data
Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2012) 125 (21): 5208–5220.
Published: 1 November 2012
...Matthew R. G. Russell; Tess Shideler; Daniel P. Nickerson; Matt West; Greg Odorizzi Summary The endosomal sorting complexes required for transport (ESCRTs) mediate the budding of intralumenal vesicles (ILVs) at late endosomes. ESCRT dysfunction causes drastic changes in endosome morphology, which...
Includes: Supplementary data
Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2012) 125 (20): 4822–4832.
Published: 15 October 2012
..., a Wnt receptor, was detected in the midbody with the endosomal sorting complex required for transport III (ESCRT-III) subunit, CHMP4B. Depletion of Wnt5a, its receptors, and Dvl increased multinucleation. The phenotype observed in Wnt5a-depleted cells was rescued by the addition of purified Wnt5a...
Includes: Multimedia, Supplementary data