... and ERK2 activities and secondary actin polymerization, which occur concomitantly with CAR1 phosphorylation, exhibit extended responses in cells expressing the non-phosphorylatable CM1234 CAR1 receptor. In mammalian cells, GPCR kinases (GRK) regulate multiple receptor pathways (Pitcher et al., 1998...

... characterised, including the extracellular-signal-regulated kinases (ERKs) 1 and 2. In a small interfering RNA (siRNA)-based high-throughput wound healing screen performed in A549 lung carcinoma cells, we identified ERK2 but not ERK1 as a strong mediator of HGF-induced motility. This finding was confirmed...

... ERK isoforms (ERK1 and ERK2, also known as MAPK3 and MAPK1, respectively) are highly homologous and have indistinguishable kinase activities in vitro, both enzymes were believed to be redundant and interchangeable. To challenge this view, we show that ERK2 silencing inhibits invasive migration of MDA...

... 1 (LSP1) binds to PKCβI and expression of B-LSP1, an LSP1 truncate containing the PKCβI binding residues, inhibits anti-IgM-induced translocation of PKCβI to the plasma membrane and anti-IgM-induced activation of ERK2. To understand the role of LSP1 in the regulation of PKCβI-dependent ERK2...

.... Governing this DNA synthesis response is a common requirement for a transient, cell area-independent extracellular signal-regulated kinase 2 (ERK2) signal. Moreover, we show that the time-integrated value of this ‘pulse’ signal provides an appropriate metric for quantifying the dependence of DNA synthesis...