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Keywords: ERK1/2
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Journal Articles
J Cell Sci (2021) 134 (21): jcs258922.
Published: 05 November 2021
...Patricia Wilson; Lina Abdelmoti; Rebecca Norcross; Eun Ryoung Jang; Malathy Palayam; Emilia Galperin ABSTRACT The ERK1/2 (also known as MAPK3 and MAPK1, respectively) signaling pathway is critical in organismal development and tissue morphogenesis. Deregulation of this pathway leads to congenital...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs230490.
Published: 27 August 2019
.... In line with this, CXCL2 overexpression attenuated proliferation, as well as differentiation, of osteoblasts in vitro . By contrast, CXCL2 downregulation promoted osteoblast expansion and differentiation. Mechanistically, CXCL2 inhibits the ERK1/2 (MAPK3/1) signaling pathway in osteoblasts. Activation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (7): jcs225698.
Published: 08 April 2019
... as oxygen-independent mechanisms, such as phosphorylation. We show here that HIF-2α is phosphorylated under hypoxia (1% O 2 ) by extracellular signal-regulated protein kinases 1 and 2 (ERK1/2; also known as MAPK3 and MAPK1, respectively) at serine residue 672, as identified by in vitro phosphorylation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4428–4441.
Published: 01 December 2015
...Eun Ryoung Jang; HyeIn Jang; Ping Shi; Gabriel Popa; Myoungkun Jeoung; Emilia Galperin ABSTRACT The scaffold protein Shoc2 accelerates activity of the ERK1 and ERK2 (ERK1/2, also known as MAPK3 and MAPK1) pathway. Mutations in Shoc2 result in Noonan-like RASopathy, a developmental disorder...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (14): 3170–3180.
Published: 15 July 2013
... has been reported. However, the molecular pathways controlling this phosphorylation and its function are still under study. Using phosphospecific antibodies, we demonstrate that ERK1/2 mediates STIM1 phosphorylation at Ser575, Ser608 and Ser621 during Ca 2+ store depletion, and that Ca 2+ entry...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (5): 1199–1206.
Published: 01 March 2013
... ERK1/2. CALHM1 also triggered activation of MEK1/2, the upstream ERK1/2-activating kinases, and of RSK1/2/3 and MSK1, two downstream effectors of ERK1/2 signaling. CALHM1-mediated activation of ERK1/2 signaling was controlled by the small GTPase Ras. Pharmacological inhibition of CALHM1 permeability...
Journal Articles
J Cell Sci (2012) 125 (19): 4620–4629.
Published: 01 October 2012
... of CD23 attenuated AIMP1-induced TNF-α secretion and AIMP1 binding to THP-1 and PBMCs. We also observed that in THP-1 and PBMCs, AIMP1-induced TNF-α secretion, mediated by CD23, involved activation of ERK1/2. Interestingly, endothelial monocyte activating polypeptide II (EMAP II), the C-terminal fragment...
Journal Articles
J Cell Sci (2012) 125 (18): 4264–4277.
Published: 15 September 2012
... migration. Using a combination of pharmacological inhibition and gene silencing approaches, we found that UTP activates the P2Y2 purinergic receptor and Gαq protein to inhibit EGF/ERK1/2-induced cell migration in keratinocytes. Using a keratinocyte cell line expressing an inducible form of the Raf kinase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (14): 3320–3332.
Published: 15 July 2012
... upregulation of ARNT showed the opposite. In ARNT-deficient monolayer cultures and 3D epidermal equivalents, the downregulation of AREG was concurrent with a decline of EGFR and ERK1/2 phosphorylation. TSA, a potent suppressor of HDAC activity, abolished the effects of ARNT deficiency, implying a role...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (20): 3515–3524.
Published: 15 October 2011
...Mauro Sbroggiò; Alessandro Bertero; Silvia Velasco; Federica Fusella; Emanuele De Blasio; Wadie F. Bahou; Lorenzo Silengo; Emilia Turco; Mara Brancaccio; Guido Tarone Extracellular signal-regulated kinase 1/2 (ERK1/2) signalling is a key pathway in cardiomyocyte hypertrophy and survival in response...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (7): 1043–1054.
Published: 01 April 2011
..., which are considered hallmarks of nitric oxide (NO) toxicity. In neuroblastoma cells, BSO treatment also induces cell proliferation arrest through the ERK1/2-p53 pathway that finally results in caspase-independent apoptosis, as evident from the translocation of apoptosis-inducing factor from...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (6): 969–977.
Published: 15 March 2011
...Ceri M. Wiggins; Peter Tsvetkov; Mark Johnson; Claire L. Joyce; Christopher A. Lamb; Nia J. Bryant; David Komander; Yosef Shaul; Simon J. Cook BIM-extra long (BIM EL ), a pro-apoptotic BH3-only protein and part of the BCL-2 family, is degraded by the proteasome following activation of the ERK1/2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (1): 19–24.
Published: 01 January 2011
...Balaji Bandyopadhyay; Arum Han; Jinyao Dai; Jianhua Fan; Yong Li; Mei Chen; David T. Woodley; Wei Li TGFβ binding to the TGFβ receptor (TβR) activates R-Smad-dependent pathways, such as Smad2/3, and R-Smad-independent pathways, such as ERK1/2. The mechanism of the TGFβ–TβRII–TβRI–Smad2/3 pathway...
Journal Articles
J Cell Sci (2010) 123 (18): 3084–3093.
Published: 15 September 2010
.... In the present work, STIM1 was found to be a target of extracellular-signal-regulated kinases 1 and 2 (ERK1/2) in vitro, and we have defined the ERK1/2-phosphorylated sites on the STIM1 sequence. Using HEK293 cells stably transfected for the expression of tagged STIM1, we found that alanine substitution mutants...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (22): 3729–3736.
Published: 15 November 2008
...-type macrophages. ERK1/2 activity was reduced in PAK1 –/– macrophages during adhesion, and inhibition of ERK1/2 activation in wild-type macrophages was sufficient to increase the spread area and mimic the lamellipodial dynamics of PAK1 –/– macrophages. Together, these data indicate that PAK1 signals...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (13): 2197–2207.
Published: 01 July 2008
...-terminus, localization of Smad to the nucleus as well as Smad-driven promoter activity exclusively in oral keratinocytes but not in OSCC cells. The effect of EGF on TGFβ1-mediated Smad-driven promoter activity and N-cadherin expression was reversed when activation of ERK1/2 was blocked. Although EGF...
Journal Articles
J Cell Sci (2007) 120 (12): 2053–2065.
Published: 15 June 2007
.../2 activation and cellular migration, indicating that the integrin-αvβ3–ERK1/2 signaling pathway is crucial in mediating CTGF function. Moreover, the cDNA microarray analysis revealed CTGF-mediated regulation of the prometastatic gene S100A4 . Transfection of MCF-7/CTGF cells with AS-S100A4 reversed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (10): 2156–2167.
Published: 15 May 2006
..., in C3 cells, F-actin is refractory to this secretagogue. Furthermore, F-actin depolymerisation with latrunculin B restores glucose-stimulated insulin secretion in C3 cells. In parallel, glucose-stimulated ERK1/2 activation is greater in B1 than in C3 cells, and is potentiated in both sublines following...
Journal Articles
J Cell Sci (2005) 118 (15): 3263–3275.
Published: 01 August 2005
...-rich tyrosine kinase (PYK2) in osteoclasts. Engagement of αvβ3 integrin triggered ERK1/2 phosphorylation, but the underlying molecular mechanism was surprisingly independent of the well known Shc/Ras/Raf-1 cascade, and of phosphorylated MAP/ERK kinase (MEK)1/2, so far the only recognized direct...
Journal Articles
J Cell Sci (2005) 118 (8): 1663–1671.
Published: 15 April 2005
...Joana Castro Barros; Christopher J. Marshall Oncogenic transformation often leads to the disruption of the actin cytoskeleton. Activation of the classical Ras-Raf-MEK1/2-ERK1/2 signalling cascade has been implicated in the effects of oncogenes such as Ras and Src on the cytoskeleton. Many...
Includes: Supplementary data