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Keywords: ERK
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Journal Articles
J Cell Sci (2017) 130 (2): 466–479.
Published: 15 January 2017
..., respectively; hereafter ERK) stimulates the transcriptional activity of HIF-1α by inhibiting its CRM1 (XPO1)-dependent nuclear export. Here, we demonstrate that phosphorylation by ERK also regulates the association of HIF-1α with a so-far-unknown interaction partner identified as mortalin (also known as GRP75...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2016) 129 (18): 3437–3448.
Published: 15 September 2016
... conditioned by ERK1/2 activation. Moreover, immunohistochemistry analysis of hippocampal dentate gyrus showed that the percentage of Ki67 + cells markedly increased in bradykinin-treated mice, and ERK1/2 inhibition affected this neurogenic response. The progress of neurogenesis depended on sustained ERK...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (19): 4234–4245.
Published: 01 October 2014
... (PBS containing 0.5% Triton X-100 and protease inhibitor) at 4°C for 6 h. Before the kinase reaction, the GST-fusion MRS proteins were pre-incubated with 500 µM ATP for 10 min at room temperature, and the kinase reactions were performed at 30°C for 30 min by adding ERK (Cell Science), [γ- 32 P]ATP...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (13): 2967–2982.
Published: 01 July 2014
... downregulation coincides with the switch from proliferation to contact-inhibited quiescence. We reveal a novel contextual interrelationship whereby positive and negative feedback between three major signalling pathways – EGFR–ERK, PI3K–AKT and Wnt–β-catenin – enable autocrine-regulated tissue homeostasis as an...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (8): 1829–1839.
Published: 15 April 2014
... in 39% of stit mutants, the Stit Y762F version only rescued lethality in 6% of the mutants ( Fig. 2D ). Thus, Y 762 provides the major binding site for Stit effectors and has a crucial function in Stit signaling in vivo . stit mutants show reduced diphosphorylated (dp)ERK accumulation at...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (21): 5005–5017.
Published: 01 November 2013
... ERK and phosphoinositide 3-kinase (PI3K) signalling divides Xenopus embryonic wound healing into two phases. In the first phase, activated ERK suppresses PI3K activity, and is responsible for the activation of Rho and myosin-2, which drives actomyosin cable formation and constriction. The second phase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (17): 3990–3999.
Published: 01 September 2013
... form tight junctions and express very little endogenous Crumbs3, to show that inducing expression of the polarity protein Scribble is sufficient to promote tight junction formation. We show this occurs through an epithelial-to-mesenchymal (EMT) pathway that involves Scribble suppressing ERK...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (15): 3370–3379.
Published: 01 August 2013
... exit that is necessary for myogenic differentiation. Furthermore, we identify Erk as a relevant target of Flt3L signaling during myogenesis, and demonstrate that Flt3L suppresses Erk signaling through p120RasGAP. In summary, our work reveals an unexpected role for an immunoregulatory cytokine in...
Journal Articles
J Cell Sci (2013) 126 (6): 1333–1344.
Published: 15 March 2013
... of Biologists Ltd 2013 APPL1 ERK MTMR2 Phosphoinositol 3-phosphate PI(3)P Endocytosis Phosphorylation To quantify the colocalization of selected proteins, Pearsons's correlation coefficient (PC) values were calculated using the JACoP plug-in ( Bolte and Cordelières, 2006 ) within...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (3): 722–731.
Published: 01 February 2013
... ACAP2 Cadherin Cancer EGF receptor Epithelial–mesenchymal transition EMT Erk Glioma Integrin Tumor invasiveness The migratory potential of cells is determined by the composition of the receptor proteome present at the cell surface. Integrins engage components of the extracellular matrix...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (9): 2198–2211.
Published: 01 May 2012
...)-induced cell differentiation has a latent process, which is dependent on ERK activity and gene expression and required for subsequent neurite extension. A latent process can be considered as a preparation step that decodes extracellular stimulus information into cellular functions; however, molecular...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (7): 1032–1042.
Published: 01 April 2011
...-interacting protein-1 (JIP1) and kinase-D-interacting substrate of 220 kDa (Kidins220). KLC1ser460 is a predicted mitogen-activated protein kinase (MAPK) target site, and we show that extracellular-signal-regulated kinase (ERK) phosphorylates this residue in vitro. We also demonstrate that inhibition of ERK...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (24): 4259–4270.
Published: 15 December 2010
...Chi Xu; Min-Hua Hong; Le-Sha Zhang; Yuan-Yuan Hou; Yu-Hua Wang; Fei-Fei Wang; Yue-Jun Chen; Xue-Jun Xu; Jie Chen; Xin Xie; Lan Ma; Zhi-Qiang Chi; Jing-Gen Liu Distinct opioid receptor agonists have been proved to induce differential patterns of ERK activation, but the underlying mechanisms remain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (24): 4310–4320.
Published: 15 December 2010
...Christopher J. Caunt; Craig A. McArdle Many stimuli activate the extracellular signal-regulated kinase (ERK) by phosphorylation on the TEY motif. Activated ERK characteristically accumulates in the nucleus, but the underlying mechanisms involved are unclear. Using automated microscopy to explore...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (16): 2725–2732.
Published: 15 August 2010
... recruitment of signals to the leading edge of migrating cells, under conditions where the aPKC-exocyst control is globally abrogated. We found that activation of ERK but not JNK at focal adhesions recovers the majority of the migratory loss attributed to ERK action, demonstrating a necessary role for active...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (7): 1081–1088.
Published: 01 April 2010
... ( engj@medizin.uni-leipzig.de ) 28 1 2010 © 2010. 2010 Chemokines Astrocytes Schwann cells Cell proliferation Erk p38 PKC Akt The CXC chemokine SDF-1 (stromal cell derived factor-1; also known as CXCL12) was originally isolated as a pre-B-cell growth-stimulating factor...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (6): 903–916.
Published: 15 March 2010
...Catherine Qiurong Pan; Yih-cherng Liou; Boon Chuan Low BPGAP1 is a multidomain Rho GTPase-activating protein (RhoGAP) that promotes Erk activation and cell motility. However, the molecular mechanism of how these two processes are linked and regulated remains unclear. Here, we show that the RhoGAP...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (5): 682–689.
Published: 01 March 2010
...-mediated signals in osteoblasts are crucial for normal postnatal bone homeostasis. * Author for correspondence ( yangx@nic.bmi.ac.cn ) 27 11 2009 © 2010. 2010 Gab1 Osteoblast Bone mass AKT ERK Apoptosis Dysregulation of osteoblast and osteoclast activities and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (24): 4516–4525.
Published: 15 December 2009
... level, requires both the ERK and phosphoinositide 3-kinase (PI3K) signalling pathways and is mediated by the transcription factor ERRα. Interestingly, the effect is independent of Akt-TOR signalling, a major regulator of cell growth in these cells. This separation of the pathways that drive...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (19): 3554–3565.
Published: 01 October 2009
... silencing of Kidins220/Arms gene transcription. Additionally, Kidins220/ARMS knockdown decreases ERK activation and basal neuronal viability, and enhances neuronal death under excitotoxic conditions. Our results demonstrate Kidins220/ARMS participation in neuronal life and death pathways, and constitute the...
Includes: Supplementary data