... 2013 8 01 2014 © 2014. Published by The Company of Biologists Ltd 2014 Coatomer Arf4 Scyl1 γ-COP ERGIC-53 Tubulation Early secretory pathway Coatomer (COPI)-coated vesicles carry cargo between the stacks of the Golgi complex and in a retrograde direction from the cis...

... 2 2010 © 2010. 2010 Cargo receptor CD59 COPII ER export signal ERGIC-53 Folate receptor Glycosylphosphatidylinositol-anchored proteins p23 p24 Sec24 isoforms Lipid rafts Exocytic proteins are synthesized in the endoplasmic reticulum (ER) and move along the secretory...

..., instead, aggregation occurs in smooth tubular vesicles and is controlled by N -glycan-dependent interactions with ER-Golgi intermediate compartment 53 (ERGIC-53). In cells containing smooth Russell bodies, ERGIC-53 co-localizes with μΔCH1 aggregates in a Ca 2+ -dependent fashion. Our findings identify...

...Christian Appenzeller-Herzog; Hans-Peter Hauri Protein traffic moving from the endoplasmic reticulum (ER) to the Golgi complex in mammalian cells passes through the tubulovesicular membrane clusters of the ER-Golgi intermediate compartment (ERGIC), the marker of which is the lectin ERGIC-53...

...Houchaima Ben-Tekaya; Kota Miura; Rainer Pepperkok; Hans-Peter Hauri The endoplasmic reticulum-Golgi intermediate compartment (ERGIC) defined by the cycling lectin ERGIC-53 consists of tubulovesicular clusters, but it is unknown if these membranes are transport vehicles or stationary entities. Here...

... protein ERGIC-53 carries a C-terminal diphenylalanine motif that is required for efficient ER export. Here we show that this motif can be functionally substituted by a single phenylalanine or tyrosine at position -2, two leucines or isoleucines at position -1 and -2 or a single valine at position -1...

...Hans-Peter Hauri; Felix Kappeler; Helena Andersson; Christian Appenzeller ABSTRACT The ER-Golgi intermediate compartment (ERGIC) marker ERGIC-53 is a mannose-specific membrane lectin operating as a cargo receptor for the transport of glycoproteins from the ER to the ERGIC. Lack of functional ERGIC...

...Judith Klumperman; Anja Schweizer; Henrik Clausen; Bor Luen Tang; Wanjin Hong; Viola Oorschot; Hans-Peter Hauri ABSTRACT To establish recycling routes in the early secretory pathway we have studied the recycling of the ER-Golgi intermediate compartment (ERGIC) marker ERGIC-53 in HepG2 cells...