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Keywords: ERAD
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Journal Articles
J Cell Sci (2021) 134 (16): jcs257790.
Published: 18 August 2021
...Lucie M. Wolf; Annika M. Lambert; Julie Haenlin; Michael Boutros ABSTRACT WNT signalling is important for development in all metazoans and is associated with various human diseases. The ubiquitin–proteasome system (UPS) and regulatory endoplasmic reticulum-associated degradation (ERAD) have been...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (21): jcs248526.
Published: 05 November 2020
... physiology . Mol. Biol. Cell   20 , 2083 - 2095 . 10.1091/mbc.e08-11-1126 Habeck , G. , Ebner , F. A. , Shimada-Kreft , H. and Kreft , S. G. ( 2015 ). The yeast ERAD-C ubiquitin ligase Doa10 recognizes an intramembrane degron . J. Cell Biol.   209 , 261 - 273 . 10.1083/jcb...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (17): jcs217760.
Published: 05 September 2018
... respond to compromised proteostasis, we compared rhabdomyosarcoma cells that were sensitive (RMS13) or resistant (RMS13-R) to the Hsp70 inhibitor MAL3-101. We discovered that endoplasmic reticulum-associated degradation (ERAD) and autophagy were activated in RMS13-R cells, suggesting that resistant cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (17): 2883–2892.
Published: 01 September 2017
... system in a process called ER-associated protein degradation (ERAD). During infection with human cytomegalovirus (HCMV), the viral US2 protein targets HLA class I molecules (HLA-I) for degradation via ERAD to avoid elimination by the immune system. US2-mediated degradation of HLA-I serves as a paradigm...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2014) 127 (16): 3603–3613.
Published: 15 August 2014
... work is properly attributed. ERAD Nuclear membrane Nuclear proteasome Protein degradation Ubiquitylation The confinement of the genome within the nucleus by the nuclear envelope is a hallmark of eukaryotic cells. The nuclear envelope is composed of two membrane layers, the inner...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (14): 3017–3023.
Published: 15 July 2014
...Tslil Ast; Naama Aviram; Silvia Gabriela Chuartzman; Maya Schuldiner ABSTRACT The endoplasmic reticulum (ER) identifies and disposes of misfolded secretory pathway proteins through the actions of ER-associated degradation (ERAD) pathways. It is becoming evident that a substantial fraction...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (18): 4136–4146.
Published: 15 September 2013
... of external ER stress. We find that during unstressed growth conditions, loss of ire-1 or xbp-1 compromises basic ER functions required for the metabolism of secreted proteins, including translation, folding and secretion. Notably, by compromising ER-associated degradation (ERAD) and phagocytosis, loss of ire...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (9): 1962–1968.
Published: 01 May 2013
... interacts with the ER chaperone GRP78/BiP, the ER-associated degradation (ERAD) machinery and with misfolded proinsulin. Unexpectedly, knockdown of SDF2L1 in INS-1 (insulin 2 C96Y-GFP) cells increased the degradation kinetics of mutant proinsulin, suggesting that SDF2L1 regulates substrate availability...
Journal Articles
J Cell Sci (2012) 125 (12): 2930–2939.
Published: 15 June 2012
... Ubx1–Ubx7. Their functions are largely unknown, except for Ubx2 that is a well-characterized ERAD protein. During ERAD, Ubx2 links the substrate recognition machinery to the dislocation machinery by use of its UBA domain, which binds ubiquitylated substrates, and its UBX domain, which interacts...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (7): 1727–1737.
Published: 01 April 2012
...Pascal St-Pierre; Thao Dang; Bharat Joshi; Ivan R. Nabi Gp78 (also known as AMFR and RNF45) is an E3 ubiquitin ligase that targets proteins for proteasomal degradation through endoplasmic reticulum (ER)-associated degradation (ERAD). In this study, we showed that gp78-mediated ubiquitylation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (19): 3332–3343.
Published: 01 October 2011
... degradation (ERAD) dysfunction. Furthermore, UPR-adapted mHtt cells succumbed to misfolded protein stresses that could be tolerated by adapted wild-type cells. Thus, mHtt expression impairs misfolded secretory protein turnover, decreases the ER stress threshold, and increases cell vulnerability to insults...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (24): 4465–4472.
Published: 15 December 2009
... protein response and degradation by ERAD. If misfolded rod opsin escapes degradation, it aggregates and forms intracellular inclusions. Therefore, it is important to identify the chaperones that mediate the folding or degradation of rod opsin. ER degradation enhancing α-mannosidase-like 1 (EDEM1) can...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (23): 4393–4400.
Published: 01 December 2009
... essential for protein function. We now show that the previously identified inhibitor of ER-associated degradation (ERAD) eeyarestatin 1 (ES I ) is a potent inhibitor of protein translocation. We have characterised this inhibition of ER translocation both in vivo and in vitro, and provide evidence that ES I...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (24): 4377–4387.
Published: 15 December 2007
...Ilana Shapira; Dana Charuvi; Yechiel Elkabetz; Koret Hirschberg; Shoshana Bar-Nun Endoplasmic reticulum-associated degradation (ERAD) eliminates aberrant proteins from the secretory pathway. Such proteins are retained in the endoplasmic reticulum and targeted for degradation by the ubiquitin...
Journal Articles
J Cell Sci (2007) 120 (4): 682–691.
Published: 15 February 2007
... channel. * Author for correspondence (e-mail: kbr20@cam.ac.uk ) 17 11 2006 © The Company of Biologists Limited 2007 2007 ER translocation ER quality control ERAD 19S regulatory particle Rpt proteins Yeast Ribosome binding Proteasomes are responsible for misfolded...
Journal Articles
J Cell Sci (2006) 119 (11): 2342–2353.
Published: 01 June 2006
... degradation (ERAD). The 66-residue N-terminal segment carrying the PEST sequence is mainly responsible for SCD1 degradation and this segment induced instability in an otherwise stable ER membrane protein. Furthermore, SCD1 was degraded constitutively irrespective of the cellular levels of unsaturated fatty...
Journal Articles
J Cell Sci (2005) 118 (8): 1577–1586.
Published: 15 April 2005
.... * Author for correspondence (e-mail: koty@post.tau.ac.il ) 28 1 2005 © The Company of Biologists Limited 2005 2005 Pendrin Green fluorescent protein Endoplasmic reticulum Aggregation Folding ERAD Newly synthesized transmembrane proteins are co-translationally inserted...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (14): 2897–2908.
Published: 15 June 2004
.... * Author for correspondence (e-mail: papazian@mednet.ucla.edu ) 3 2 2004 © The Company of Biologists Limited 2004 2004 Potassium channels Calnexin ERAD Proteasome Glycan trimming ER glucosidase/mannosidase Shaker Voltage-dependent Glycosylation Biogenesis of membrane...
Journal Articles
J Cell Sci (2003) 116 (11): 2361–2373.
Published: 01 June 2003
...Elizabeth A. Palmer; Kristina B. Kruse; Sheara W. Fewell; Sean M. Buchanan; Jeffrey L. Brodsky; Ardythe A. McCracken In the eukaryotic cell, a protein quality control process termed endoplasmic reticulum-associated degradation (ERAD) rids the ER of aberrant proteins and unassembled components...