... localization to endoplasmic reticulum (ER) tubules. In Saccharomyces cerevisiae , Sed4 interacts with Sec16 at the ER exit site (ERES) to promote ER export. Upon loss of this interaction, Sed4 failed to assemble at the ERES but was enriched in the ER tubules in a luminal region-dependent manner. Fusion...

... organisms could uncover proteins that are involved in nuclear size determination. Finally, the finding that NE assembly begins with ER tubules, rather than vesicles, has opened a new avenue of investigation that is focused on understanding the properties of the ER and of the proteins that contribute to ER...