... that are in proximity to ER–mitochondria contact sites (ERMCSs) in mammalian cells. Disruption of ERMCSs, achieved through depletion of ER–mitochondria tethering proteins, leads to the disappearance of PBs but not SGs. This effect can be reversed by inhibiting autophagy through both genetic and pharmacological means...

... structure, whereas Mtx3 deletion does not. Notably, the loss of Myo19 and Miro1/2 alters mitochondrial lipid composition, reducing cardiolipin and its precursors, suggesting Myo19 and Miro1/2 influence cristae indirectly via lipid transfer at ER–mitochondria contact sites. Author for correspondence...

... the crowded cytoplasm of eukaryotic cells. We discuss the effect of forces on two organelles, the nucleus and the mitochondrion. Mechanobiology Membrane Mitochondria Nucleus Organelle ER–mitochondria contact sites Organelle fission Actin Dynamin-related protein 1 Mitochondrial fission factor...