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Keywords: ER
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Journal Articles
J Cell Sci (2023) 136 (17): jcs260934.
Published: 1 September 2023
..., such as cell polarization, attachment, migration, proliferation, mitosis, differentiation, etc., and the close physical and functional connection of the Golgi with the ER, it is surprising that the Golgi has remained a largely unexplored target for drug intervention. The finding that EMT cells are sensitive...
Includes: Supplementary data
Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2023) 136 (9): jcs261094.
Published: 9 May 2023
...Tomohiro Yorimitsu; Ken Sato ABSTRACT COPII proteins assemble at ER exit sites (ERES) to form transport carriers. The initiation of COPII assembly in the yeast Saccharomyces cerevisiae is triggered by the ER membrane protein Sec12. Sec16, which plays a critical role in COPII organization, localizes...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2020) 133 (24): jcs249136.
Published: 29 December 2020
... contexts and constitutes the most important signaling entity in excitable cells. To enable responsive behavior, cytosolic Ca 2+ concentrations are kept low through sequestration into organellar stores, particularly the endoplasmic reticulum (ER), but also mitochondria and lysosomes. Specific triggers...
Journal Articles
Journal Articles
J Cell Sci (2018) 131 (22): jcs217992.
Published: 21 November 2018
... composition. Perturbation of endoplasmic reticulum (ER) homeostasis through alteration in membrane phospholipids activates the unfolded protein response (UPR) and causes dramatic transcriptional and translational changes in the cell. To restore cellular homeostasis, the three highly conserved UPR transducers...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2017) 130 (24): 4087–4096.
Published: 15 December 2017
... on endosomes and, ultimately, to its destruction in the lysosome. We focus on the spatial and temporal considerations underlying the molecular decisions that govern this complex journey and discuss how additional cellular organelles – particularly the ER – play active roles in the regulation of receptor...
Journal Articles
J Cell Sci (2016) 129 (17): 3231–3237.
Published: 1 September 2016
...Kazuo Kurokawa; Yasuyuki Suda; Akihiko Nakano ABSTRACT The Sar1 GTPase controls coat assembly on coat protein complex II (COPII)-coated vesicles, which mediate protein transport from the endoplasmic reticulum (ER) to the Golgi. The GTP-bound form of Sar1, activated by the ER-localized guanine...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (8): 1635–1648.
Published: 15 April 2016
... accompanied by spasticity and paralysis. Two genes implicated in HSPs encode proteins that regulate endoplasmic reticulum (ER) morphology. Atlastin 1 (ATL1, also known as SPG3A) encodes an ER membrane fusion GTPase and reticulon 2 (RTN2, also known as SPG12) helps shape ER tube formation. Here, we use a new...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (5): 921–929.
Published: 1 March 2016
...Zuyuan Xu; Madhusudana Rao Chikka; Hongai Xia; Donald F. Ready ABSTRACT The endoplasmic reticulum (ER) serves virtually all aspects of cell physiology and, by pathways that are incompletely understood, is dynamically remodeled to meet changing cell needs. Inositol-requiring enzyme 1 (Ire1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (19): 4270–4278.
Published: 1 October 2014
...Sung-jun Jung; Ji Eun Hani Kim; Johannes H. Reithinger; Hyun Kim ABSTRACT The Sec62–Sec63 complex mediates post-translational translocation of a subset of primarily secretory proteins into the endoplasmic reticulum (ER) in yeast. Therefore, it has been thought that membrane proteins, which...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (17): 3675–3686.
Published: 1 September 2014
...Alexander Aranovich; Rong Hua; Andrew D. Rutenberg; Peter K. Kim ABSTRACT The endoplasmic reticulum (ER) is required for the de novo biogenesis of peroxisomes in mammalian cells. However, its role in peroxisome maintenance is unclear. To explore ER involvement in the maintenance of peroxisomes, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (5): 947–953.
Published: 1 March 2014
... the existence of yet-unknown motors for organelle movement. Here we tested a role of the endoplasmic reticulum (ER) as propelling force for cytoplasmic streaming during cell expansion. Through quantitative live-cell analyses in wild-type Arabidopsis thaliana cells and mutants with compromised ER structure...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (2): 341–353.
Published: 15 January 2014
..., we show that gp130 deletion mutants, but not wild-type gp130, localise predominantly to intracellular compartments, notably the endoplasmic reticulum (ER) and early endosomes. One of the most frequent mutants, gp130 Y186-Y190del (ΔYY) is retained in the ER quality control system because of its...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (10): 2151–2156.
Published: 15 May 2013
...Mia Kyed Jakobsen; Zhiliang Cheng; Sheung Kwan Lam; Elizabeth Roth-Johnson; Robyn M. Barfield; Randy Schekman Summary Trafficking of the chitin synthase Chs2p from the endoplasmic reticulum (ER) to the bud-neck in late mitosis is tightly regulated by the cell cycle via phosphorylation of serine...
Journal Articles
J Cell Sci (2012) 125 (17): 4014–4025.
Published: 1 September 2012
... and yeast cells, the Zw10 homologues, together with the conserved RINT1/Tip20p and NAG/Sec39p proteins, form a second complex involved in vesicle transport between Golgi and ER. However, it is currently unknown whether Zw10 and the NAG family member Rod are also involved in Drosophila membrane trafficking...
Includes: Multimedia, Supplementary data
Journal Articles
In collection:
Lipid biology
J Cell Sci (2012) 125 (12): 2930–2939.
Published: 15 June 2012
...Chao-Wen Wang; Shu-Chuan Lee Summary Lipid droplets (LDs) are central organelles for maintaining lipid homeostasis. However, how cells control the size and number of LDs remains largely unknown. Herein, we report that Ubx2, a UBX-domain-containing protein involved in endoplasmic reticulum (ER...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2009) 122 (14): 2331–2336.
Published: 15 July 2009
... pathway from the ER. J. Cell Biol. 173 , 521 -532. Koch, A., Schneider, G., Luers, G. H. and Schrader, M. ( 2004 ). Peroxisome elongation and constriction but not fission can occur independently of dynamin-like protein 1. J. Cell Sci. 117 , 3995 -4006. Kragt, A., Voorn-Brouwer, T., van...