...Marko Marjanović; Ana-Matea Mikecin Dražić; Marija Mioč; Mladen Paradžik; Filip Kliček; Mislav Novokmet; Gordan Lauc; Marijeta Kralj ABSTRACT Epithelial-to-mesenchymal transition (EMT) gives rise to cells with properties similar to cancer stem cells (CSCs). Targeting the EMT program to selectively...

... by epithelial-to-mesenchymal transition (EMT). Mounting evidence has indicated that long non-coding RNAs (lncRNAs) also contribute to tumor progression. We report the identification of 114 novel lncRNAs that change their expression during TGFβ-induced EMT in murine breast cancer cells (referred to as EMT...

... signaling. We found that clusterin potentiated the effects of eHsp90α on activation of the AKT, ERK and NF-κB protein families, epithelial-to-mesenchymal transition (EMT) and migration in breast cancer cells. Furthermore, in vivo investigations demonstrated similar synergistic effects of eHsp90α...

...Varisa Pongrakhananon; Onsurang Wattanathamsan; Masatoshi Takeichi; Paninee Chetprayoon; Pithi Chanvorachote ABSTRACT Epithelial-to-mesenchymal transition (EMT) plays pivotal roles in a variety of biological processes, including cancer invasion. Although EMT involves alterations of cytoskeletal...

...Meera Saxena; Sai A. Balaji; Neha Deshpande; Santhalakshmi Ranganathan; Divya Mohan Pillai; Sravanth Kumar Hindupur; Annapoorni Rangarajan ABSTRACT The developmental programme of epithelial-mesenchymal transition (EMT), involving loss of epithelial and acquisition of mesenchymal properties, plays...

... to MNU inhibited polarisation at the basolateral domain, increased dispersal of the Golgi at the apical domain and induced an epithelial-to-mesenchymal transition (EMT)-like phenotype as well as invasion. This altered Golgi phenotype correlated with impaired intracellular trafficking. Inhibition of DNA...

...Jing Wang; Kumar Nikhil; Keith Viccaro; Lei Chang; Max Jacobsen; George Sandusky; Kavita Shah ABSTRACT We uncovered a crucial role for the Aurora kinase A (AURKA)–Twist1 axis in promoting epithelial-to-mesenchymal transition (EMT) and chemoresistance in pancreatic cancer. Twist1 is the first EMT...

...Jonathan Bergeman; Alexia Caillier; François Houle; Laurence M. Gagné; Marc-Étienne Huot ABSTRACT Epithelial-to-mesenchymal transition (EMT) is a process by which cancer cells gain the ability to leave the primary tumor site and invade surrounding tissues. These metastatic cancer cells can further...

... for correspondence ( [email protected] ) Competing interests The authors declare no competing or financial interests. 21 7 2014 14 4 2015 © 2015. Published by The Company of Biologists Ltd 2015 Rac Rho Adherens junctions E-cadherin EMT Cell–cell adhesion is essential...

...Rangarajan Padmanabhan; Lisa A. Taneyhill The epithelial‐to‐mesenchymal transition (EMT) is important for the formation of migratory neural crest cells during development and is co‐opted in human diseases such as cancer metastasis. Chick premigratory cranial neural crest cells lose intercellular...

...Omer Keinan; Amir Kedan; Nancy Gavert; Michael Selitrennik; SoHui Kim; Thomas Karn; Sven Becker; Sima Lev ABSTRACT The involvement of epithelial-mesenchymal transition (EMT) in breast cancer metastasis has been demonstrated in many studies. However, the intracellular proteins and signaling pathways...

...Ewa Grudzien-Nogalska; Brent C. Reed; Robert E. Rhoads ABSTRACT Downregulation of CPEB1, a sequence-specific RNA-binding protein, in a mouse mammary epithelial cell line (CID-9) causes epithelial-to-mesenchymal transition (EMT), based on several criteria. First, CPEB1 knockdown decreases protein...

... processes requiring cell movement. Specifically, they regulate epithelial-to-mesenchymal transitions (EMT) where an epithelial cell severs intercellular junctions, degrades basement membrane and becomes a migratory, mesenchymal-like cell. Interestingly, Slug expression has been observed in angiogenic...

...Maren Diepenbruck; Lorenz Waldmeier; Robert Ivanek; Philipp Berninger; Phil Arnold; Erik van Nimwegen; Gerhard Christofori ABSTRACT The cellular changes during an epithelial–mesenchymal transition (EMT) largely rely on global changes in gene expression orchestrated by transcription factors. Tead...

...Lina Sun; He Li; Junliang Chen; Yasumasa Iwasaki; Toru Kubota; Mayumi Matsuoka; Aiguo Shen; Qi Chen; Yong Xu Summary Epithelial-mesenchymal transition (EMT) has an essential role in organogenesis and contributes to a host of pathologies, including carcinogenesis. Hypoxia (low oxygen supply) aids...

... to form tight junctions and express very little endogenous Crumbs3, to show that inducing expression of the polarity protein Scribble is sufficient to promote tight junction formation. We show this occurs through an epithelial-to-mesenchymal (EMT) pathway that involves Scribble suppressing ERK...

...Wu Zhou; Jean Paul Thiery Summary Epithelial–mesenchymal transition (EMT) can be induced by several pleiotropically activated transcription factors, including the zinc-finger E-box-binding protein Zeb1. Mechanisms regulating Zeb1 expression have been partly uncovered, showing a critical role...

...-induced epithelial-to-mesenchymal transition (EMT), engage signaling molecules that normally facilitate cellular migration and invasion of mesenchymal cells. We identify lipoma preferred partner (LPP) as an indispensable regulator of TGFβ-induced migration and invasion of ErbB2-expressing breast cancer...

.... L. , Albertson   D. G. , Nieto   M. A. et al ( 2005 ). Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability.   Nature   436 , 123 – 127 . 10.1038/nature03688 Rahajeng   J. , Giridharan   S. S. , Cai   B. , Naslavsky   N. , Caplan   S...

...Steven M. Frisch; Michael Schaller; Benjamin Cieply Summary The oncogenic epithelial–mesenchymal transition (EMT) contributes to tumor progression in various context-dependent ways, including increased metastatic potential, expansion of cancer stem cell subpopulations, chemo-resistance and disease...