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Keywords: EGFR
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Journal Articles
J Cell Sci (2021) 134 (18): jcs255927.
Published: 17 September 2021
... (EGFR) ligand epiregulin (EREG), results in its apical mistrafficking and transformation in vivo . However, the mechanisms underlying these dramatic effects are unknown. Using a doxycycline-inducible system in 3D Matrigel cultures, we now show that induction of Y156A EREG in fully formed MDCK cysts...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (17): jcs258456.
Published: 03 September 2021
... localization compared with other markers of in vivo ERK activation. EGF EGFR LET-23 LET-60 LIN-45 MEK-2 MAPK C. elegans Nuclear translocation nKTR KTR Vulval development Cell fate patterning National Institutes of Health http://dx.doi.org/10.13039/100000002 R01GM121625...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (23): jcs242461.
Published: 11 December 2020
... consider how the mechanical environments encountered in vivo intersect with this diverse signaling, focusing on receptor endocytosis. We discuss the implications of mechanically tuned integrin signaling for growth factor signaling, using the epidermal growth factor receptor (EGFR) as an illustrative...
Journal Articles
J Cell Sci (2020) 133 (16): jcs244020.
Published: 25 August 2020
... by which the lncRNA maternally expressed gene 3 ( MEG3 ) mediates RCC progression by regulating ST3Gal1 transcription and EGFR sialylation is still unrevealed. Here, we found that the expression of MEG3 was higher in adjacent tissues than in RCC tissues, as well as downregulated in RCC cell lines compared...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (18): jcs220251.
Published: 20 September 2018
...Maximilien Courgeon; Dan Qing He; Hui Hua Liu; Kevin Legent; Jessica E. Treisman ABSTRACT Mammalian members of the ErbB family, including the epidermal growth factor receptor (EGFR), can regulate transcription, DNA replication and repair through nuclear entry of either the full-length proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (24): 4087–4096.
Published: 15 December 2017
... processes. In order to control these signals, activated receptors are endocytosed and thoroughly curated by the endosomal network of intracellular vesicles and proteolytic organelles. In this Review, we follow the epidermal growth factor (EGF) receptor (EGFR) from ligand engagement, through its voyage...
Journal Articles
J Cell Sci (2017) 130 (17): 2808–2820.
Published: 01 September 2017
... the ShcD (also known as Shc4) homolog, which also uniquely promotes ligand-independent phosphorylation of the epidermal growth factor receptor (EGFR). We now report that cultured cells expressing ShcD exhibit reduced EGF uptake, commensurate with a decrease in EGFR surface presentation. Under basal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 90–96.
Published: 01 January 2017
... and homeostasis. However, the signals regulating this process are not well understood. We asked whether shedding is controlled by epidermal growth factor receptor (EGFR), an important driver of intestinal growth and differentiation. In 3D ileal enteroid culture and cell culture models (MDCK, IEC-6 and IPEC-J2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (13): 2625–2637.
Published: 01 July 2016
... nutrient uptake. Yet, the protein machineries and mechanisms that drive endocytic recycling remain ill-defined. Here, we establish that NECAP2 regulates the endocytic recycling of EGFR and transferrin receptor. Our analysis of the recycling dynamics revealed that NECAP2 functions in the fast recycling...
Journal Articles
J Cell Sci (2015) 128 (24): 4499–4511.
Published: 15 December 2015
...-mediated destruction of Arm. We find that Ras–Dsor1 activity is independent of upstream activation by EGFR, and instead it appears to be activated by the insulin-like growth factor receptor to promote Wg signaling. Taken together, our results suggest that there is a new crosstalk pathway between insulin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4366–4379.
Published: 01 December 2015
... and epithelial–mesenchymal transition (EMT) in epithelial cysts. MMP-9 secreted by carcinoma cells cleaves cellular E-cadherin (encoded by CDH1 ) from epithelial cells to generate soluble E-cadherin (sE-cad), a pro-oncogenic protein. We show that sE-cad induces EGFR activation, resulting in lumen filling in MDCK...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2015) 128 (4): 755–767.
Published: 15 February 2015
...Neftali Flores-Rodriguez; David A. Kenwright; Pei-Hua Chung; Andrew W. Harrison; Flavia Stefani; Thomas A. Waigh; Victoria J. Allan; Philip G. Woodman ABSTRACT Endosomal sorting complexes required for transport (ESCRT)-0 sorts ubiquitylated EGFR within the early endosome so that the receptor can...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (4): 815–827.
Published: 15 February 2015
... growth factor receptor (EGFR). Here, we show that the adaptor protein TOM1 is a new direct binding partner of PI5P. We identify the domain of TOM1 involved in this interaction and characterize the binding motif. Finally, we demonstrate that the recruitment of TOM1 by PI5P on signaling endosomes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (2): 397–407.
Published: 15 January 2015
... are poorly understood. Here, we show that depletion of SEPT9 decreases surface levels of epidermal growth factor receptors (EGFRs) by enhancing receptor degradation. We identify a consensus motif within the SEPT9 N-terminal domain that supports its association with the adaptor protein CIN85 (also known...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (18): 3983–3997.
Published: 15 September 2014
... in exosomes and results in the linkage of the two tyrosine kinase receptors TrkB (also known as NTRK2) and EGFR with sortilin. Using in vitro models, we demonstrate that this sortilin-containing complex exhibits a control on endothelial cells and angiogenesis activation through exosome transfer...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (13): 2967–2982.
Published: 01 July 2014
... downregulation coincides with the switch from proliferation to contact-inhibited quiescence. We reveal a novel contextual interrelationship whereby positive and negative feedback between three major signalling pathways – EGFR–ERK, PI3K–AKT and Wnt–β-catenin – enable autocrine-regulated tissue homeostasis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (8): 1712–1725.
Published: 15 April 2014
... cytoskeletal rearrangements are required to form invadopodia, and here we identify an association between Src, epidermal growth factor receptor (EGFR), and β1 integrin that facilitates invadopodia formation. The association of Src, EGFR and β1 integrin is dependent upon membrane traffic that is mediated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (5): 994–1006.
Published: 01 March 2014
...-receptor tyrosine kinase that has been implicated in trafficking and degradation of epidermal growth factor receptor (EGFR), yet its precise functions remain elusive. In this report, we investigate the role of Ack1 in EGFR trafficking and show that Ack1 partially colocalises to Atg16L-positive structures...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2014) 127 (3): 663–672.
Published: 01 February 2014
... as siRNA-mediated depletion of UBAP1, but not MVB12A and MVB12B, disrupts ubiquitin-dependent sorting at the MVB. EGFR Endosome TSG101 ESCRT-I UBAP1 VPS37 MVB12 Activated epidermal growth factor receptor (EGFR) is ubiquitylated, then internalised and sorted to the multivesicular body (MVB...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (23): 5377–5390.
Published: 01 December 2013
...Amee J. George; Brooke W. Purdue; Cathryn M. Gould; Daniel W. Thomas; Yanny Handoko; Hongwei Qian; Gregory A. Quaife-Ryan; Kylie A. Morgan; Kaylene J. Simpson; Walter G. Thomas; Ross D. Hannan Summary The angiotensin type 1 receptor (AT 1 R) transactivates the epidermal growth factor receptor (EGFR...
Includes: Supplementary data